Abstract:
:Progressive chromosome 21 loss in individuals with trisomy 21 or Down syndrome (DS) is supposedly related to their premature senescence. In addition, the telomere hypothesis of cellular aging involving telomere shortening in normal and accelerated aging in vivo and in vitro is well documented. This study investigated the integrity of two chromosome 21 regions (the 21q telomere and the 21q22.13-q22.2 region) and their relationship with aging by means of fluorescence in situ hybridization (FISH) in lymphocytes and gingival fibroblasts cells. The use of tissues from different germ layers allows detection of mosaicism. Chromosome variations in tissue from the neuroectoderm layer could explain the variable phenotype of DS. This approach is original in the literature. Lymphocyte and gingival fibroblast nuclei from 18 affected individuals aged 5-54 years were analyzed. Although not significant (P = 0.06), analysis from 11 tissue-matched individuals as well as the comparison between lymphocytes and fibroblasts from different subjects (P = 0.05) suggested that lymphocyte cells are more likely to miss 21q telomere signals. Hence, gingival fibroblasts are probably capable of more efficient cell repair, and the occurrence of mosaicism is more related to cell proliferation than to germ layer origin. Investigation of the 21q22.13-q22.2 region from six tissue-matched individuals and from different DS patients revealed no significant differences between the tissues.
journal_name
J Oral Scijournal_title
Journal of oral scienceauthors
de Arruda Cardoso Smith M,Borsatto-Galera B,Feller RI,Gonçalves A,Oyama RS,Segato R,Chen E,Carvalheira GM,Filho AS,Burbano RR,Payão SLdoi
10.2334/josnusd.46.171subject
Has Abstractpub_date
2004-09-01 00:00:00pages
171-7issue
3eissn
1343-4934issn
1880-4926journal_volume
46pub_type
杂志文章abstract::Sebaceous adenoma of the salivary gland is a rare tumor comprising 0.1% of all salivary gland neoplasms and less than 0.5% of salivary adenomas. Histologically, sebaceous adenomas are benign neoplasms consisting of sebaceous cells arranged in nests forming acinar and duct-like structures. Oncocytic metaplasia may also...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.51.641
更新日期:2009-12-01 00:00:00
abstract::We analysed the concentration of radioactive cesium in dried Lentinula edodes (Shiitake) produced in Japan, and evaluated its use as an indicator of radioactive contamination. We collected Lentinula edodes (Shiitake) mushrooms grown on wood in 38 prefectures from north to south, and measured 137Cs, 134Cs and 40K conce...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.43.145
更新日期:2001-06-01 00:00:00
abstract::Since 1998, the authors have been working to improve the oral health of children at kindergartens and primary schools in the Kingdom of Tonga (Tonga). Our primary activity has been a school-based fluoride mouth-rinsing (FMR) program. FMR is performed using 7-10 mL of a 0.2% NaF solution for 1 min once per week at each...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.54.343
更新日期:2012-01-01 00:00:00
abstract::Zirconia is widely employed as a material during dental implant work because of its superior esthetics. This study sought to evaluate the impact of titanium or zirconia implant abutments on epithelial attachments after ultrasonic cleaning. These implants were inserted into the extraction socket of rat maxillary first ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.19-0332
更新日期:2020-01-01 00:00:00
abstract::Susceptibility to and development of periodontal disease have been associated with psychological conditions. Previous studies have associated the presence of polymorphism in the promoter region of the serotonin transporter with several behavioral traits and psychological conditions such as depression, anxiety, and str...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.50.193
更新日期:2008-06-01 00:00:00
abstract::This report describes the bonding technique and clinical course of porcelain laminate veneer restorations applied to discolored maxillary incisors and canines. The patient was an 18-year-old woman, and tooth reduction was limited to the enamel. Laminate veneer restorations were made with a feldspathic porcelain materi...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.56.227
更新日期:2014-09-01 00:00:00
abstract::This study evaluated and compared the effect of conventional and digital wax-ups on three lateral occlusion variables: contact number, contact area, and steepness. Dental casts of 10 patients with Angle Class I relationship were included in the study. All patients required fixed prosthodontic treatment that would affe...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.16-0610
更新日期:2017-01-01 00:00:00
abstract::High mobility group box 1 (HMGB1) was originally defined as a nuclear protein. However, later studies showed that HMGB1 was released from damaged cells into the extracellular milieu and functioned as a danger signaling molecule. HMGB1 has also been shown to exert proliferative and chemoattractant effects on many cell ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.55.45
更新日期:2013-03-01 00:00:00
abstract::The aim of this in vitro study was to compare the color stability of commercially available porcelain, reinforced acrylic, and conventional acrylic denture teeth materials used in removable prostheses. Two brands of porcelain (Unilux-Enta Lactona-Holland and Vivoperl-Ivoclar-Liechtenstein), 2 brands of reinforced acry...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.43.193
更新日期:2001-09-01 00:00:00
abstract::The purpose of the present study was to evaluate periodontal health status in children with sickle cell disease (SCD). Forty-nine children with SCD and 39 systemically healthy sex- and age-matched children were enrolled in the study. Plaque index, gingival index, bleeding on probing, pocket depth, salivary volume, and...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.16-0796
更新日期:2018-01-01 00:00:00
abstract::A rare case of primary intraosseous carcinoma (PIOC) arising from an odontogenic cyst in a 58-year-old man is reported. Clinical and radiological examinations revealed an odontogenic cyst of the maxilla. Histopathologically, the lesion was composed of a cyst with a parakeratotic epithelial lining and well-differentiat...
journal_title:Journal of oral science
pub_type: 杂志文章,评审
doi:10.2334/josnusd.44.49
更新日期:2002-03-01 00:00:00
abstract::Porphyromonas gingivalis FimA fimbriae have been classified into 6 genotypes (types I-V and Ib) based on the diversity of the fimA genes encoding the fimbrial subunits. We investigated the prevalence of fimA genotype in Japanese children. Dental plaque specimens were obtained from 400 subjects (age; 2 to 15 years), in...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.54.77
更新日期:2012-03-01 00:00:00
abstract::We report here a clinico-statistical study of congenital absence of the permanent canines (CAPC). Sixty-five cases (22 men and 43 women) of CAPC were found in the files of 35,927 outpatients, an incidence of 0.18%. Thirty-seven cases had single absence of the canine and 28 cases had multiple absences. There were 42 ca...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.46.247
更新日期:2004-12-01 00:00:00
abstract::This in vitro study aimed to analyze the effect of including xylitol into a fluoridated dentifrice to provide protection against enamel erosion with or without abrasion. Bovine enamel specimens were subjected to erosion or erosion plus abrasion (7 days) and the treatment with the following dentifrices: 10% xylitol; 10...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.53.163
更新日期:2011-06-01 00:00:00
abstract::We report a rare case of osteoglophonic dysplasia affecting father and daughter. Osteoglophonic dysplasia is a very rare skeletal dysplasia with craniosynostosis, multiple radiolucencies of bone and clinical anodontia. It is an autosomal dominant disorder characterised by short stature. The affected children have norm...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.52.167
更新日期:2010-03-01 00:00:00
abstract::The aims of this study were to investigate gender differences in frontal sinus morphology and to estimate differences between Fijian and Western Samoan populations. Cephalograms of 118 Fijians (59 male, 59 female), 80 W. Samoans (33 male, 47 female) and 89 Japanese (60 male, 29 female) were used in this study. The thi...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.40.25
更新日期:1998-03-01 00:00:00
abstract::This study evaluated the effect of a modified tray design on the accuracy of implant impressions in comparison with the non-splinted and splinted impression techniques. Two titanium frameworks were produced to fit two parallel implants and two divergent implants with a 15o angle. According to the frameworks employed, ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.19-0482
更新日期:2020-09-26 00:00:00
abstract::Placement of composite resin restorations in deep subgingival cavities can damage surrounding soft tissues. In addition, commonly used resin-based composites (RBCs) might interfere with wound healing and periodontal health. To clarify cellular interactions with RBCs, we used an MTT assay to investigate adhesion of pri...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.16-0827
更新日期:2018-03-24 00:00:00
abstract::In astronauts and cosmonauts, exposure to microgravity has been associated with several physiological changes, including an osteoporosis like loss of bone mass. It has been reported that head-down tilt bed-rest studies mimic many of the observations seen in space flights. There has been no study of the effects of mand...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.52.385
更新日期:2010-09-01 00:00:00
abstract::The signs and symptoms of persistent temporomandibular joint (TMJ)/muscle disorder (TMJD) pain suggest the existence of a central neural dysfunction or a problem of pain amplification. The etiology of chronic TMJD is not known; however, female sex hormones have been identified as significant risk factors. Converging l...
journal_title:Journal of oral science
pub_type: 杂志文章,评审
doi:10.2334/josnusd.19-0405
更新日期:2020-03-28 00:00:00
abstract::The aim of this study was to evaluate the subcutaneous biocompatibility of three root canal sealers in rats. Thirty Wistar rats were divided into three groups according to three time periods (15, 30 and 60 days). Sterilized polyethylene tubes filled with root canal sealers (AH Plus, Epiphany & Grossman), and one empty...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.53.15
更新日期:2011-03-01 00:00:00
abstract::We investigated the associations of mouthguard awareness and use with the rate and type of orofacial trauma during sports activities among professional athletes. In this cross-sectional study of athletes aged 12 to 22 years who trained for participation in national and international competitions, data were collected b...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.56.239
更新日期:2014-12-01 00:00:00
abstract::The oral route of human papillomavirus (HPV) transmission is not fully understood. It has been suggested that genital infection can act as a reservoir for oral HPV infection. We investigated the presence of oral HPV DNA and anti-HPV IgA in the buccal cavity of patients with a histopathologic diagnosis of cervical HPV ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.53.451
更新日期:2011-12-01 00:00:00
abstract::Temporomandibular joint (TMJ) disease classification and subsequent treatment selection are highly debated subjects within dentistry and medicine. Several suggestions for diagnostic classification and treatment algorithms have been proposed thus far without achieving a clear gold standard. A universally accepted diagn...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.19-0128
更新日期:2020-01-01 00:00:00
abstract::It is widely accepted that vitamin E (VE) acts as an antioxidant and is involved in various metabolic systems including the regulation of gene expression and inhibition of cell proliferation. The most predominant isoform of VE in the living body is α-tocopherol. However, the influence of α-tocopherol on bone marrow me...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.17-0422
更新日期:2018-01-01 00:00:00
abstract::Ammonium hexafluorosilicate (AHF) has been applied to arrest caries without discoloration. The purpose of this study was to observe structural and elemental changes of demineralized and AHF applied primary tooth enamel. Enamel from the labial surface of 20 primary canines was divided into an unground side and ground s...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.55.115
更新日期:2013-01-01 00:00:00
abstract::A prospective cohort study was designed to measure marginal bone level changes at 36-month follow-up and to evaluate the influence of biologically relevant, anatomic and stress-related variables. STROBE guidelines were followed. Totally, 748 implants were inserted into 350 patients. Standardized periapical radiographs...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.58.49
更新日期:2016-01-01 00:00:00
abstract::This pilot study evaluated, by culture testing, the effectiveness of lethal photosensitization for the microbiological treatment of peri-implantitis in dogs. Experimental peri-implantitis was induced by ligature placement for 2 months. Following ligature removal, plaque control was instituted by scrubbing with 0.12% c...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.45.17
更新日期:2003-03-01 00:00:00
abstract::Asthma is a chronic inflammatory disease, and its prevalence is relatively high among children. Optimal management of asthma often requires long-term pharmacotherapy; however, the effects of these medications on orthodontic treatment is uncertain. We evaluated the effects of the leukotriene LTD4 receptor antagonist mo...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.16-0482
更新日期:2017-01-01 00:00:00
abstract::The purpose of this study was to investigate the antimicrobial efficacy of six groups of antibiotics and calcium hydroxide against Enterococcus faecalis biofilm in a membrane filter model. Two-day-old E. faecalis (ATCC 29212) biofilm was exposed to ampicillin, co-trimoxazole, erythr omycin, oxytetracycline, vancomycin...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.49.161
更新日期:2007-06-01 00:00:00