Abstract:
:It is widely accepted that vitamin E (VE) acts as an antioxidant and is involved in various metabolic systems including the regulation of gene expression and inhibition of cell proliferation. The most predominant isoform of VE in the living body is α-tocopherol. However, the influence of α-tocopherol on bone marrow mesenchymal cells (BMMCs) in a background of type II diabetes mellitus (DM) has not been investigated. The focus of the present study was to clarify the effect of α-tocopherol on BMMCs derived from rats with type II DM and the underlying mechanisms involved. BMMCs were isolated from rats with type II DM. The BMMCs were either untreated or exposed to α-tocopherol at concentrations of 1.0, 10, and 100 μM, and the resulting effects of α-tocopherol on cell proliferation, H2O2 activity, and antioxidant and inflammatory cytokine production were examined. At 100 μM, α-tocopherol had no effect on cell proliferation, but H2O2 activity was significantly increased. At 10 μM, α-tocopherol increased the gene expression of IL-1β, and markedly promoted that of TNF-α. Expression of catalase in the presence of 100 μM α-tocopherol was lower than for the other concentrations. At a low concentration, α-tocopherol exerted good antioxidant and anti-inflammatory effects on BMMCs. The study suggests that maintaining α-tocopherol at a low concentration might promote the recovery of BMMCs from oxidative stress.
journal_name
J Oral Scijournal_title
Journal of oral scienceauthors
Noguchi M,Yamawaki I,Takahashi S,Taguchi Y,Umeda Mdoi
10.2334/josnusd.17-0422subject
Has Abstractpub_date
2018-01-01 00:00:00pages
579-587issue
4eissn
1343-4934issn
1880-4926journal_volume
60pub_type
杂志文章abstract::Age-related deterioration in physical and oral health reduces healthy life expectancy and is thus an important problem for very elderly people. We investigated the effects of satisfaction with dietary life (SDL) in everyday life on oral health-related quality of life (OHRQoL) and subjective well-being and examined ass...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.16-0414
更新日期:2017-01-01 00:00:00
abstract::The need for domiciliary dental care (DDC) for people requiring long-term nursing care is increasing as the super-aged society of Japan grows still older. Dysphagia diagnosis and rehabilitation are becoming more important in DDC; thus, the need for prostheses used for dysphasia rehabilitation is presumed to be increas...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.18-0053
更新日期:2018-12-29 00:00:00
abstract::Since abnormal tooth morphology can predispose to caries and periodontal disease, careful management of fused teeth is essential. In this paper we report a rare case of a fused molar and supernumerary tooth and describe its management. Caries was removed from the tooth complex under local anesthesia. The pulp chamber ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.48.39
更新日期:2006-03-01 00:00:00
abstract::Enamel pearls are anatomical structures that can bring about clinical implications if associated with the retention of plaque, in turn resulting in periodontal disease. In an attempt to avoid periodontal disease, the removal and treatment of these enamel pearls, may be a necessity in some circumstances. A total of 45,...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.52.257
更新日期:2010-06-01 00:00:00
abstract::Melatonin is produced by the pineal gland and regulates various physiological processes including osteoblast differentiation and bone formation. Bone sialoprotein (BSP) is a mineralized connective tissue-specific protein expressed in the early stage of cementum and bone mineralization. To elucidate the effects of mela...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.56.67
更新日期:2014-03-01 00:00:00
abstract::This study evaluated the effect of a modified tray design on the accuracy of implant impressions in comparison with the non-splinted and splinted impression techniques. Two titanium frameworks were produced to fit two parallel implants and two divergent implants with a 15o angle. According to the frameworks employed, ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.19-0482
更新日期:2020-09-26 00:00:00
abstract::Ammonium hexafluorosilicate (AHF) has been applied to arrest caries without discoloration. The purpose of this study was to observe structural and elemental changes of demineralized and AHF applied primary tooth enamel. Enamel from the labial surface of 20 primary canines was divided into an unground side and ground s...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.55.115
更新日期:2013-01-01 00:00:00
abstract::The purpose of this study was to identify and compare the presence of HCMV and EBV-1 in subgingival plaque, unstimulated saliva and peripheral blood of patients with chronic periodontitis. Forty patients diagnosed with chronic periodontitis (mean age, 41.7 years) were recruited. Unstimulated saliva, subgingival plaque...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.50.25
更新日期:2008-03-01 00:00:00
abstract::Endodontic therapy is indicated for cases of traumatic tooth dislocation associated with pulp necrosis and/or inflammatory resorption. Here we describe the management of a maxillary left lateral permanent incisor that suffered lateral luxation, leading to pulp necrosis and root resorption, in a 13-year-old boy. The tr...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.56.311
更新日期:2014-12-01 00:00:00
abstract::The aim of this study was to evaluate the physico-chemical and biocompatibility characteristics of two different hydroxyapatites. Physical and chemical properties were analyzed using granulometric analysis, scanning electron microscopy (SEM), X-ray energy-dispersion (EDX), X-ray fuorescence (XRF) and X-ray diffraction...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.48.219
更新日期:2006-12-01 00:00:00
abstract::High mobility group box 1 (HMGB1) was originally defined as a nuclear protein. However, later studies showed that HMGB1 was released from damaged cells into the extracellular milieu and functioned as a danger signaling molecule. HMGB1 has also been shown to exert proliferative and chemoattractant effects on many cell ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.55.45
更新日期:2013-03-01 00:00:00
abstract::A shift in caries prevalence from occlusal surfaces to approximal surfaces has been demonstrated by epidemiological studies. Two recent meta-analyses evaluated the performance of visual examination and radiography for carious lesion detection, and reported low sensitivity but high specificity for early approximal cari...
journal_title:Journal of oral science
pub_type: 杂志文章,评审
doi:10.2334/josnusd.16-0595
更新日期:2017-09-14 00:00:00
abstract::A clear cell variant of calcifying epithelial odontogenic tumor (CCEOT) affecting an extraosseous site is described. A 60-year-old male patient presented with gingival swelling on the lingual side of the anterior mandible. The results of biopsy suggested clear cell odontogenic carcinoma, and marginal resection of the ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.17-0116
更新日期:2018-09-23 00:00:00
abstract::External invasive resorption is an uncommon but aggressive type of external resorption. This report outlines the management of an advanced case of external invasive resorption with mineral trioxide aggregate (MTA). The clinical and radiographic follow-up after 60 months revealed a functional tooth with a stable period...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.53.397
更新日期:2011-09-01 00:00:00
abstract::A retrospective analysis was conducted on patients diagnosed with and treated for keratocystic odontogenic tumor (KCOT) at Mashhad School of Dentistry between 1996 and 2006. The patients comprised 44 men and 30 women with a mean age of 27.08 years. Among the total of 83 lesions, 56 (67.5%) occurred in the mandible and...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.49.229
更新日期:2007-09-01 00:00:00
abstract::We report here a clinico-statistical study of congenital absence of the permanent canines (CAPC). Sixty-five cases (22 men and 43 women) of CAPC were found in the files of 35,927 outpatients, an incidence of 0.18%. Thirty-seven cases had single absence of the canine and 28 cases had multiple absences. There were 42 ca...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.46.247
更新日期:2004-12-01 00:00:00
abstract::A 58-year-old patient who smoked and had uncontrolled type 2 diabetes mellitus was referred to our clinic. The patient had a suspicious asymptomatic lesion that was diagnosed as B-cell non-Hodgkin lymphoma (NHL). Immunohistochemistry revealed intense and diffuse expression of CD20, CD10, BCL-6, and Ki-67. A positron e...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.57.59
更新日期:2015-03-01 00:00:00
abstract::Porphyromonas gingivalis FimA fimbriae have been classified into 6 genotypes (types I-V and Ib) based on the diversity of the fimA genes encoding the fimbrial subunits. We investigated the prevalence of fimA genotype in Japanese children. Dental plaque specimens were obtained from 400 subjects (age; 2 to 15 years), in...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.54.77
更新日期:2012-03-01 00:00:00
abstract::The objective of the present study was to evaluate the interest of both children and parents towards orthodontic treatment and compare it to the normative treatment need as well as to determine the factors related to such an interest. The sample consisted of 407 schoolchildren aged between 9 and 12 years and their par...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.52.101
更新日期:2010-03-01 00:00:00
abstract::Oral malignant melanoma is a rare aggressive neoplasm of melanocytic origin, usually found on the hard palate and gingiva, and representing 0.2-8% of all melanomas. Unfortunately, oral mucosal melanomas have by far the worst prognosis, and therefore early detection is indispensable for improving their prognosis. Histo...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.53.239
更新日期:2011-06-01 00:00:00
abstract::Although the main reservoir of Candida spp. is believed to be the buccal mucosa, these microorganisms can coaggregate with bacteria in subgingival biofilm and adhere to epithelial cells. Such interactions are associated with the capacity of Candida spp. to invade gingival conjunctive tissue, and may be important in th...
journal_title:Journal of oral science
pub_type: 杂志文章,评审
doi:10.2334/josnusd.52.177
更新日期:2010-06-01 00:00:00
abstract::We investigated inhibition of lesion progression in artificial enamel lesions. Lesions were created on primary and permanent anterior teeth (n = 10 each) and were divided randomly into two groups with two windows: Group 1 (window A: resin infiltration; window B: negative control) and Group 2 (window A: resin infiltrat...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.57.177
更新日期:2015-09-01 00:00:00
abstract::This in vitro study aimed to analyze the effect of including xylitol into a fluoridated dentifrice to provide protection against enamel erosion with or without abrasion. Bovine enamel specimens were subjected to erosion or erosion plus abrasion (7 days) and the treatment with the following dentifrices: 10% xylitol; 10...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.53.163
更新日期:2011-06-01 00:00:00
abstract::This pilot study evaluated, by culture testing, the effectiveness of lethal photosensitization for the microbiological treatment of peri-implantitis in dogs. Experimental peri-implantitis was induced by ligature placement for 2 months. Following ligature removal, plaque control was instituted by scrubbing with 0.12% c...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.45.17
更新日期:2003-03-01 00:00:00
abstract::Oral rehabilitation with prosthodontic treatment considerably influences the well-being and quality of life of patients after ablative oral tumor surgery. This study evaluated the effects of implant-supported prostheses (ISPs) on oral health-related quality of life (OHRQoL) and chewing ability in 10 patients who reque...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.18-0234
更新日期:2019-08-28 00:00:00
abstract::One of the objectives of this short communication was to add to the literature on the prevalence of oral recurrent aphthous stomatitis (ORAS). This research is based on a total of 11,697 randomly selected Malaysian subjects with an age range of 25-115 years and a mean age of 44.5 +/- 13.9 years who were examined for o...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.42.15
更新日期:2000-03-01 00:00:00
abstract::To investigate the prevalence, characteristics (ie, malocclusion, location, type), and sex distribution of hypodontia in an Iranian orthodontic population. A retrospective study was conducted using periapical and panoramic radiographs and study models of 1,751 subjects attending university orthodontic clinics (870 fem...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.52.455
更新日期:2010-09-01 00:00:00
abstract::A novel fast-setting calcium silicate cement with fluoride (CSC) has been developed for potential application in tooth crowns. This study compared the cytotoxicity of CSC compositions and a variety of dental materials. We tested CSC compositions (Protooth), MTA, Biodentine, Ketac Molar, Fuji II LC, Vitrebond, DeTrey Z...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.16-0751
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:This study evaluated outcomes of surgical treatment for enophthalmos after pediatric orbital blowout fracture. Associations of fracture type, fracture site, time from injury to treatment, and type of surgical procedure with treatment outcomes were assessed. METHODS:The medical records of 200 children and adole...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.20-0371
更新日期:2020-12-28 00:00:00
abstract::In this descriptive study, we investigated the relationship between the clinical characteristics of idiopathic burning mouth syndrome (iBMS) and the quality of life. Eighteen iBMS patients were interviewed about their experience with pain, oral-associated complaints, cognitive status, and self-perceived quality of lif...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.15-0683
更新日期:2016-01-01 00:00:00