Abstract:
:A study was conducted to evaluate the mechanisms underlying ectopic orofacial pain associated with tooth pulp inflammation in rats. We observed a significant decrease in the head withdrawal threshold (HWT) response to mechanical and heat stimuli applied to the ipsilateral facial skin upon application of complete Freund's adjuvant (CFA) to the upper first molar (M1TP) in comparison to application of vehicle. A large number of trigeminal ganglion (TG) neurons showed transient receptor potential vanilloid 1 (TRPV1) immunoreactivity (IR), and some of them were retrogradely labeled with fluorogold injected into the facial skin. A large number of cells showing IR for glial fibrillary acidic protein (GFAP) were observed in the 2nd compared to the 1st or 3rd branch regions of the TG, and TG cells innervating the facial skin were also surrounded by GFAP-IR cells. After administration of TRPV1 antagonist into the facial skin of M1TP CFA-treated rats, the decrease of HWTs in response to mechanical and heat stimulation of the facial skin was significantly reversed. The present findings suggest that the excitability of TG neurons is enhanced upon tooth pulp inflammation, leading to overexpression of TRPV1 in TG neurons innervating the facial skin, and that satellite glial cells are also activated, resulting in the development of ectopic orofacial pain.
journal_name
J Oral Scijournal_title
Journal of oral scienceauthors
Watase T,Shimizu K,Komiya H,Ohara K,Iwata K,Ogiso Bdoi
10.2334/josnusd.16-0854subject
Has Abstractpub_date
2018-03-24 00:00:00pages
8-13issue
1eissn
1343-4934issn
1880-4926journal_volume
60pub_type
杂志文章abstract::Endodontic therapy is indicated for cases of traumatic tooth dislocation associated with pulp necrosis and/or inflammatory resorption. Here we describe the management of a maxillary left lateral permanent incisor that suffered lateral luxation, leading to pulp necrosis and root resorption, in a 13-year-old boy. The tr...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.56.311
更新日期:2014-12-01 00:00:00
abstract::Bilateral, asymmetric anomalies of the anterior bellies of digastric muscles were observed during dissection of the submental region. Specifically, four extra muscle bundles were found between the anterior bellies of the digastric muscle. Although anomalies of the anterior bellies of digastric muscles are often observ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.53.523
更新日期:2011-12-01 00:00:00
abstract::Polyamide denture base materials are more flexible than the commonly used poly (methyl methacrylate) (PMMA). However polishability of polyamides has not been examined adequately. This study investigated the surface roughness (Ra) and clinical acceptability of samples of a polyamide denture base material and PMMA fabri...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.52.577
更新日期:2010-12-01 00:00:00
abstract::The exact cause of the formation of sialoliths is unknown. Detailed knowledge of the pathogenesis of sialolithiasis is necessary to define new therapeutic procedures. The possible presence of a sphincter system in Wharton's duct has been described frequently in the context of diagnostic sialendoscopy. Serial histologi...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.45.233
更新日期:2003-12-01 00:00:00
abstract::Sebaceous adenoma of the salivary gland is a rare tumor comprising 0.1% of all salivary gland neoplasms and less than 0.5% of salivary adenomas. Histologically, sebaceous adenomas are benign neoplasms consisting of sebaceous cells arranged in nests forming acinar and duct-like structures. Oncocytic metaplasia may also...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.51.641
更新日期:2009-12-01 00:00:00
abstract::Chromosome 6 deletions are very rare (1,2), and deletion 6q syndrome is clinically characterized by mental and/or neuromotor retardation and microcephaly (3). Other alterations frequently observed are decreased biparietal diameter, hypertelorism, hypotelorism, absent eyebrows, prominent eyes with ptosis, receding chin...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.50.493
更新日期:2008-12-01 00:00:00
abstract::This study used micro-CT to compare three obturation techniques with respect to void occurrence in canals filled with bioceramic sealer. Thirty extracted first mandibular premolars were prepared with a ProTaper Universal system and randomly allocated to three groups. Canals were obturated with gutta-percha and biocera...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.57.361
更新日期:2015-01-01 00:00:00
abstract::Oral submucous fibrosis (OSMF) is a disabling, potentially malignant condition of the oral cavity. The aetiology of OSMF is multifactorial but remains obscure. Although arecanut is considered to be the most important causative agent, responses observed in individuals using arecanut vary in relation to quantity and dur...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.53.97
更新日期:2011-03-01 00:00:00
abstract::To investigate long-term nonsurgical treatment outcomes in patients with generalized aggressive periodontitis (GAgP) and the impact of root abnormalities (RAs) and other patient-level factors in relation to GAgP progression. Patients (n = 64) from a GAgP cohort who completed active nonsurgical periodontal treatment an...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.16-0258
更新日期:2017-01-01 00:00:00
abstract::This report describes an adult case of cellular hemangioma arising in the lower lip. A 39-year-old healthy woman presented with a polypoid mass of 4 months duration. The tumor imparted little color to the overlying mucosa and was misdiagnosed as a mucous granuloma preoperatively. The lobular proliferation of plump end...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.42.177
更新日期:2000-09-01 00:00:00
abstract::Extracorporeal irradiation sterilizes resected tumor bone used as autografts in reconstruction surgery. Therapeutic irradiation is a standard technique in head and neck cancer therapy that aims to preserve organ function. Bone irradiation has a complex, mostly inhibitory, effect on remodeling and regeneration, althoug...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.16-0042
更新日期:2016-01-01 00:00:00
abstract::The purpose of this study was to explore the effects of nicotine on the activity of Streptococcus mutans (S. mutans) in soft drinks. Regular soft drinks contain large proportions of high-fructose corn syrup (HFCS), which increases the activity of S. mutans resulting in high-caries risk compared with sugar-free soft dr...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.20-0073
更新日期:2020-12-23 00:00:00
abstract::One of the objectives of this short communication was to add to the literature on the prevalence of oral recurrent aphthous stomatitis (ORAS). This research is based on a total of 11,697 randomly selected Malaysian subjects with an age range of 25-115 years and a mean age of 44.5 +/- 13.9 years who were examined for o...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.42.15
更新日期:2000-03-01 00:00:00
abstract::We explored the effects of sclerostin removal in vivo on experimental periodontitis in mice. A ligature of Porphyromonas gingivalis-saturated collagen silk was applied to the cervical region of the first molar tooth in 10 wild-type (WT) mice and 10 sclerostin-knockout (SOST-KO) mice, and the animals were fed 10% sucro...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.15-0690
更新日期:2016-01-01 00:00:00
abstract::A rare case of primary intraosseous carcinoma (PIOC) arising from an odontogenic cyst in a 58-year-old man is reported. Clinical and radiological examinations revealed an odontogenic cyst of the maxilla. Histopathologically, the lesion was composed of a cyst with a parakeratotic epithelial lining and well-differentiat...
journal_title:Journal of oral science
pub_type: 杂志文章,评审
doi:10.2334/josnusd.44.49
更新日期:2002-03-01 00:00:00
abstract::Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by recurrent thrombosis, other associated autoimmune disease, and/or obstetrical morbidity along with persistent production of antiphospholipid antibodies. Because of the nature of this systemic disease, most patients are medicated with an...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.18-0164
更新日期:2019-08-28 00:00:00
abstract::This in vitro study aimed to analyze the effect of including xylitol into a fluoridated dentifrice to provide protection against enamel erosion with or without abrasion. Bovine enamel specimens were subjected to erosion or erosion plus abrasion (7 days) and the treatment with the following dentifrices: 10% xylitol; 10...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.53.163
更新日期:2011-06-01 00:00:00
abstract::This study aimed to evaluate superficial defects and the composition of Reciproc R25 and ProTaper Retreatment file systems (Dentsply Maillefer, Ballaigues, Switzerland) used for retreatment. A total of 100 maxillary incisor teeth were randomly divided into the following two groups: Reciproc R25 (n = 25) and ProTaper R...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.15-0725
更新日期:2016-01-01 00:00:00
abstract::The signs and symptoms of persistent temporomandibular joint (TMJ)/muscle disorder (TMJD) pain suggest the existence of a central neural dysfunction or a problem of pain amplification. The etiology of chronic TMJD is not known; however, female sex hormones have been identified as significant risk factors. Converging l...
journal_title:Journal of oral science
pub_type: 杂志文章,评审
doi:10.2334/josnusd.19-0405
更新日期:2020-03-28 00:00:00
abstract::The oral route of human papillomavirus (HPV) transmission is not fully understood. It has been suggested that genital infection can act as a reservoir for oral HPV infection. We investigated the presence of oral HPV DNA and anti-HPV IgA in the buccal cavity of patients with a histopathologic diagnosis of cervical HPV ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.53.451
更新日期:2011-12-01 00:00:00
abstract::Clearfil DC Bond (DC) is a new single-step, dual-cure bonding agent. In this study, the shear bond strengths of a core build-up composite to dentin used with four bonding systems [DC, Unifil Core Self-Etching Bond (UC), Clearfil SE Bond (SE) and Cleafil tri-S Bond (TS)] were measured. The bonding ability after 7 days ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.50.329
更新日期:2008-09-01 00:00:00
abstract::Accurate diagnosis and exact treatment planning are very important for successful implant treatment. Pretreatment examination and simulations using CT can be especially effective information sources, and diagnosis by CT imaging before treatment substantially enhances the security and safety of the treatment plan. New ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.41.157
更新日期:1999-12-01 00:00:00
abstract::The need for domiciliary dental care (DDC) for people requiring long-term nursing care is increasing as the super-aged society of Japan grows still older. Dysphagia diagnosis and rehabilitation are becoming more important in DDC; thus, the need for prostheses used for dysphasia rehabilitation is presumed to be increas...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.18-0053
更新日期:2018-12-29 00:00:00
abstract::Cleidocranial dysplasia (CCD) is a rare syndrome usually caused by an autosomal dominant gene, although 40% of cases of CCD appear spontaneously with no apparent genetic cause. This condition is characterized by several cranial malformations and underdevelopment, absence of the clavicles, and multiple supernumerary an...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.48.161
更新日期:2006-09-01 00:00:00
abstract::Few prospective studies have reported the effects of periodontal therapy on patients who attempted to quit smoking. This study aimed to assess how smoking cessation affects periodontal therapy. Twenty-five smokers with periodontitis were investigated by dividing them into two groups, a smoking cessation support group ...
journal_title:Journal of oral science
pub_type: 杂志文章,多中心研究
doi:10.2334/josnusd.20-0288
更新日期:2020-12-23 00:00:00
abstract::In the treatment of diabetes-induced pathologies, beneficial results have been obtained with administration of antioxidants. Selenium is an antioxidant and essential trace element in living organisms. The aim of this study was to investigate the possible effects of selenium on the structural alterations of the mandibl...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.44.85
更新日期:2002-06-01 00:00:00
abstract:UNLABELLED:To evaluate the effectiveness of Carisolv and different auxiliary chemical substances in root canal smear layer (SL) removal. SL was produced in the centre of 40 hemi-disks of bovine root dentine. The samples were divided into four irrigation groups (G): GI (control) - 0.9% NaCl; GII - 1% NaOCl + 0.9% NaCl; ...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.48.99
更新日期:2006-09-01 00:00:00
abstract::Although the main reservoir of Candida spp. is believed to be the buccal mucosa, these microorganisms can coaggregate with bacteria in subgingival biofilm and adhere to epithelial cells. Such interactions are associated with the capacity of Candida spp. to invade gingival conjunctive tissue, and may be important in th...
journal_title:Journal of oral science
pub_type: 杂志文章,评审
doi:10.2334/josnusd.52.177
更新日期:2010-06-01 00:00:00
abstract::We investigated inhibition of lesion progression in artificial enamel lesions. Lesions were created on primary and permanent anterior teeth (n = 10 each) and were divided randomly into two groups with two windows: Group 1 (window A: resin infiltration; window B: negative control) and Group 2 (window A: resin infiltrat...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.57.177
更新日期:2015-09-01 00:00:00
abstract::Transplantation of mesenchymal stem cells (MSCs) has been extensively studied in the field of regenerative medicine. Bone regeneration is achieved via the interaction of osteoblasts and osteoclasts. However, the influence of MSCs on osteoclasts is unknown. The purpose of this study was to investigate the effect of MSC...
journal_title:Journal of oral science
pub_type: 杂志文章
doi:10.2334/josnusd.17-0315
更新日期:2019-03-28 00:00:00