Abstract:
:Five molecular dynamics computer simulations were performed on different phospholipid:sterol membrane systems in order to study the influence of sterol structure on membrane properties. Three of these simulated bilayer systems were composed of a 1:8 sterol:phospholipid ratio, each of which employed one of the sterol molecules: cholesterol, ergosterol, and lanosterol. The two other simulations were of a bilayer with a 1:1 sterol:phospholipid ratio. These simulations employed cholesterol and lanosterol, respectively, as their sterol components. The observed differences in simulations with cholesterol and lanosterol may have their implication on the form of the phospholipid/sterol phase diagram.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Smondyrev AM,Berkowitz MLdoi
10.1016/S0006-3495(01)76137-1subject
Has Abstractpub_date
2001-04-01 00:00:00pages
1649-58issue
4eissn
0006-3495issn
1542-0086pii
S0006-3495(01)76137-1journal_volume
80pub_type
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