Individual immunity and susceptibility to female genital tract infection.

Abstract:

:The responses to genital tract infection vary among different women to a far greater extent than has previously been appreciated. All women are not genetically identical and have not been exposed to identical environments; therefore it is naive to expect that a particular microorganism will elicit the identical response and have the identical sequelae for each infected individual. The genes inherited from one's parents, which contain specific polymorphisms in immune response genes, greatly influence the direction and magnitude of the immune response to microorganisms. Similarly, extrinsic variables, such as the type or quantity of a specific infection, whether there is a coinfection with another microorganism, such as an intracellular parasite, and whether an immediate hypersensitivity response is concurrently induced also determine the nature of the host response and thus the consequences of microbial exposure. Finally, factors such as the frequency of sexual intercourse and previous immune sensitization to spermatozoa or other components of a particular ejaculate also influence the outcome. An increased awareness of the uniqueness of each host will lead to the development of more precise individualized treatments and improvements in combating infectious diseases of the female genital tract.

journal_name

Am J Obstet Gynecol

authors

Witkin SS,Linhares I,Giraldo P,Jeremias J,Ledger WJ

doi

10.1067/mob.2000.104258

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

252-6

issue

1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(00)57323-2

journal_volume

183

pub_type

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