Association of Alzheimer's disease and smoking: the case for sibling controls.

Abstract:

OBJECTIVES:To study the association between cigarette smoking and Alzheimer's Disease (AD). DESIGN:Intrafamily case-control, with sibling controls and a variable number of controls per case. SETTING:AD cases were identified through the Research Registry of the University Hospitals of the Cleveland/Case Western Reserve University Alzheimer Center. PARTICIPANTS:Study subjects were 86 probable AD cases (index cases) and all of their full siblings, alive or dead, aged > or = 50 years, a total of 238 subjects. MEASUREMENTS:Exposure for each individual was ascertained with a questionnaire answered by several informants. Cognitive status of siblings of the AD cases (impaired or intact) was ascertained by telephone using validated instruments. Diagnosis of dementia in cognitively impaired siblings of index cases was not attempted. RESULTS:Chi-square analysis tested for departure from a random distribution of disease across smokers and nonsmokers within families. No significant departure was found utilizing all families (P > .40) nor utilizing those families where only the index case was affected (P > .90). Conditional logistic regression evaluated the association within families, controlling for age, sex, and education. Analyses both included and excluded secondary cases of cognitive impairment. No association was found between smoking and disease (OR = 1.26; 95% confidence interval, 0.66-2.42, and OR = 1.42; 95% confidence interval, 0.69-2.89, respectively). CONCLUSIONS:No significant association was found between smoking and cognitive status. Further, analyses based on the comparison of persons with AD with their unaffected siblings also suggest that smoking does not decrease the risk of AD.

journal_name

J Am Geriatr Soc

authors

Debanne SM,Rowland DY,Riedel TM,Cleves MA

doi

10.1111/j.1532-5415.2000.tb04756.x

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

800-6

issue

7

eissn

0002-8614

issn

1532-5415

journal_volume

48

pub_type

杂志文章
  • Detrusor underactivity: Clinical features and pathogenesis of an underdiagnosed geriatric condition.

    abstract::Urinary incontinence and other lower urinary tract symptoms exert a major influence on the health and independence of frail older people. Detrusor underactivity (DU) is defined as a contraction of reduced strength and/or duration, resulting in prolonged bladder emptying and/or a failure to achieve complete bladder emp...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1111/j.1532-5415.2006.00917.x

    authors: Taylor JA 3rd,Kuchel GA

    更新日期:2006-12-01 00:00:00

  • Factors Affecting Discharge to Home of Geriatric Intermediate Care Facility Residents in Japan.

    abstract:OBJECTIVES:To investigate factors associated with lower likelihood of discharge to home from geriatric intermediate care facilities in Japan. DESIGN:Retrospective cohort study. SETTING:We used data from the nationwide long-term care (LTC) insurance claims database (April 2012-March 2014). PARTICIPANTS:Study particip...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15295

    authors: Morita K,Ono S,Ishimaru M,Matsui H,Naruse T,Yasunaga H

    更新日期:2018-04-01 00:00:00

  • Changes in elderly welfare hotel residents during a one-year period.

    abstract::After a one-year interval, a structured interview designed to assess the quality of life was again conducted with most of the tenants in a single-room occupancy hotel in New York City. Comparisons was made between the two sets of findings. During the year, a program had been in effect to provide social, psychiatric, r...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1975.tb00316.x

    authors: Plutchik R,McCarthy M,Hall BH

    更新日期:1975-06-01 00:00:00

  • Conceptions of dementia in a multiethnic sample of family caregivers.

    abstract::Understanding variability in conceptions of dementia in multiethnic populations is important to improve care and guide research. The objectives of this study were to describe caregiver conceptions of dementia using a previously developed typology and to examine the correlates of conceptions of dementia in a multiethni...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2005.53409.x

    authors: Hinton L,Franz CE,Yeo G,Levkoff SE

    更新日期:2005-08-01 00:00:00

  • Risk factors for disability subtypes in older persons.

    abstract:OBJECTIVES:To identify risk factors for five different subtypes of disability. DESIGN:Prospective cohort study. SETTING:Greater New Haven, Connecticut. PARTICIPANTS:Seven hundred fifty-four community-living residents aged 70 and older and initially nondisabled in four essential activities of daily living (bathing, d...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2009.02443.x

    authors: Gill TM,Murphy TE,Barry LC,Allore HG

    更新日期:2009-10-01 00:00:00

  • Inadequate Risk Adjustment Impacts Geriatricians' Performance on Medicare Cost and Quality Measures.

    abstract:OBJECTIVES:Medicare value-based payment programs evaluate physicians' performance on their patients' annual Medicare costs and clinical outcomes. However, little is known about how geriatricians, who disproportionately provide care for medically complex older adults, perform on these measures. DESIGN:A retrospective s...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16297

    authors: Johnston KJ,Wen H,Joynt Maddox KE

    更新日期:2020-02-01 00:00:00

  • Microfloral characterization of the tongue coating and associated risk for pneumonia-related health problems in institutionalized older adults.

    abstract:OBJECTIVES:To characterize a comprehensive outline of the oral microflora related to pneumonia in older adults. DESIGN:Prospective and retrospective longitudinal study. SETTING:Community. PARTICIPANTS:Long-term hospitalized patients and people in nursing homes (343 subjects, aged > or =65). MEASUREMENTS:Subjects we...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2010.02867.x

    authors: Takeshita T,Tomioka M,Shimazaki Y,Matsuyama M,Koyano K,Matsuda K,Yamashita Y

    更新日期:2010-06-01 00:00:00

  • Drug prescribing for ambulatory patients 85 years of age and older.

    abstract::Drug prescribing for ambulatory patients greater than or equal to 85 years of age was studied using data from the 1980 National Ambulatory Medical Care Survey (NAMCS) on office visits to physicians. NAMCS is a survey by the US National Center for Health Statistics, which collected information on office visits and extr...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1984.tb05855.x

    authors: Knapp DA,Knapp DA,Wiser TH,Michocki RJ,Nuessle SJ,Knapp WK

    更新日期:1984-02-01 00:00:00

  • Perception of poor health in the healthy older adult.

    abstract::A survey of 977 community subjects aged 65 or older identified 719 of them as not impaired in physical health. Of these, 104 (14 percent) perceived their physical status to be poor, whereas 615 (86 percent) accurately perceived it to be unimpaired. There were no significant differences between the two groups with rega...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1979.tb06051.x

    authors: Blazer DG 2nd,Houpt JL

    更新日期:1979-07-01 00:00:00

  • Postantibiotic colonization with Clostridium difficile in nursing home patients.

    abstract::Clostridium difficile causes pseudomembranous colitis and is responsible for 20% to 25% of cases of postantibiotic diarrhea. In an earlier study, nursing-home patients with C. difficile infection were noted to have a high mortality rate. Because most of these infected patients had been treated with antibiotics, it was...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1990.tb03539.x

    authors: Thomas DR,Bennett RG,Laughon BE,Greenough WB 3rd,Bartlett JG

    更新日期:1990-04-01 00:00:00

  • Feasibility and accuracy of a postcard diary system for tracking healthcare utilization of community-dwelling older persons.

    abstract:OBJECTIVE:To test the feasibility of and to validate a self-report weekly postcard diary of health care utilization. DESIGN:Case-series and validation study. SETTING:Community-based sample of fee-for-service and health maintenance organization (HMO) patients. PARTICIPANTS:A convenience sample of 24 community-dwellin...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1995.tb06105.x

    authors: Reuben DB,Wong RC,Walsh KE,Hays RD

    更新日期:1995-05-01 00:00:00

  • Effect of aging on serum albumin.

    abstract::Some studies have shown a negative association between age and serum albumin. Several of these studies included older people with known disease. Disease may reduce albumin in any age group. Other studies have shown no association between age and albumin. To investigate the association of age and albumin, albumin level...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1989.tb06917.x

    authors: Cooper JK,Gardner C

    更新日期:1989-11-01 00:00:00

  • Effects of home-based primary care on Medicare costs in high-risk elders.

    abstract:OBJECTIVES:To determine the effect of home-based primary care (HBPC) on Medicare costs and mortality in frail elders. DESIGN:Case-control concurrent study using Medicare administrative data. SETTING:HBPC practice in Washington, District of Columbia. PARTICIPANTS:HBPC cases (n = 722) and controls (n = 2,161) matched ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.12974

    authors: De Jonge KE,Jamshed N,Gilden D,Kubisiak J,Bruce SR,Taler G

    更新日期:2014-10-01 00:00:00

  • The effects of terodiline and meladrazine on severe motor urge incontinence in geriatric patients.

    abstract::Twenty-five geriatric patients with severe motor urge incontinence were treated with terodiline and meladrazine separately and in combination. Because of poor general state of health and serious concomitant diseases the frequency of dropouts was high. Separate administration of the drugs improved the majority of the p...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1532-5415.1985.tb02856.x

    authors: Beisland HO,Fossberg E

    更新日期:1985-01-01 00:00:00

  • Correlates of kyphosis in older women. The Fracture Intervention Trial Research Group.

    abstract:OBJECTIVE:To determine the association between kyphosis (degree of forward curvature of the thoracic spine) and measures of spinal osteoporosis (height loss and vertebral fractures) and chronic back pain and disability in older women. DESIGN:A cross-sectional study. SETTING:Eleven clinical centers in the United State...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1997.tb01470.x

    authors: Ensrud KE,Black DM,Harris F,Ettinger B,Cummings SR

    更新日期:1997-06-01 00:00:00

  • Physical Activity and Amyloid-β Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment.

    abstract:OBJECTIVES:To examine the associations between amyloid-β brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose-response relationship. DESIGN:Cross-sectional study. SETTING:French community-dwelling people. PARTICIPANTS:Elderly adults with...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/jgs.13530

    authors: de Souto Barreto P,Andrieu S,Payoux P,Demougeot L,Rolland Y,Vellas B,Multidomain Alzheimer Preventive Trial\/Data Sharing Alzheimer Study Group.

    更新日期:2015-08-01 00:00:00

  • Evaluating patients' warfarin requirements.

    abstract::Seventy consecutive patients receiving warfarin as an anticoagulant were evaluated for the relationship between the response to the loading dose of warfarin and the response to the maintenance dose. No patients were excluded because of complicating diseases or the concurrent use of other drugs. There was a moderate co...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1980.tb00116.x

    authors: Jones BR,Baran A,Reidenberg MM

    更新日期:1980-01-01 00:00:00

  • Frequent falling and motor vehicle collision involvement of older drivers.

    abstract:OBJECTIVES:To examine the relationship between frequent falls in older drivers and motor vehicle collision (MVC) involvement. DESIGN:Cross-sectional. SETTING:North central Alabama. PARTICIPANTS:Population-based sample of 2,000 licensed drivers aged 70 and older. MEASUREMENTS:Self-reported history of falling two or ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.12594

    authors: Huisingh C,McGwin G Jr,Orman KA,Owsley C

    更新日期:2014-01-01 00:00:00

  • The relationship of psychosocial factors to total mortality among older Japanese-American men: the Honolulu Heart Program.

    abstract:OBJECTIVE:To examine the predictive value of psychosocial factors as risk factors for all-cause mortality. DESIGN:A community-based longitudinal cohort study: The Honolulu Heart Program. SETTING:Population-based study conducted in Oahu, Hawaii. PARTICIPANTS:Three thousand four hundred and ninety-seven men age 71 to ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1046/j.1532-5415.2001.49148.x

    authors: Ceria CD,Masaki KH,Rodriguez BL,Chen R,Yano K,Curb JD

    更新日期:2001-06-01 00:00:00

  • Frailty and Delirium in Older Adults: A Systematic Review and Meta-Analysis of the Literature.

    abstract:OBJECTIVES:To evaluate the relationship between frailty and delirium. DESIGN:Systematic review and meta-analysis. SETTING:MEDLINE, EMBASE, PubMed, Scopus, Web of Science, and Google Scholar databases were searched for articles on frailty and delirium published on or before October 31, 2017. PARTICIPANTS:Individuals ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,meta分析

    doi:10.1111/jgs.15503

    authors: Persico I,Cesari M,Morandi A,Haas J,Mazzola P,Zambon A,Annoni G,Bellelli G

    更新日期:2018-10-01 00:00:00

  • Treating in Place: Acute Care for Long-Stay Residents in Nursing Facilities Under a CMS Initiative.

    abstract:BACKGROUND/OBJECTIVES:Nursing facility (NF) residents are commonly hospitalized, and many of these hospitalizations may be avoidable. A Centers for Medicare & Medicaid Services (CMS) initiative enables participating NFs to bill Medicare for providing on-site acute care to long-stay residents diagnosed with one of six a...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16901

    authors: Segelman M,Ingber MJ,Feng Z,Khatutsky G,Bercaw L,Gasdaska A,Huber B,Voltmer H

    更新日期:2020-11-12 00:00:00

  • Subclinical hypothyroidism in a biethnic, urban community.

    abstract:OBJECTIVES:To evaluate the association between hypothyroidism, and the health status of older Hispanic and non-Hispanic white (NHW) men and women. To accomplish this, we determined the prevalences of the treated and untreated conditions and examined the associations between an elevated serum thyroid stimulating hormone...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1999.tb01593.x

    authors: Lindeman RD,Schade DS,LaRue A,Romero LJ,Liang HC,Baumgartner RN,Koehler KM,Garry PJ

    更新日期:1999-06-01 00:00:00

  • Multidimensional risk assessment versus age as criterion for retirement of airline pilots.

    abstract:OBJECTIVE:To determine whether airline pilots over the age of 60 pose a hazard to aviation safety and whether risk assessment could replace age-based retirement. DATA SOURCES:A computer-assisted literature search (MEDLINE), expert consultation, and government reports. STUDY SELECTION:Original studies on flight perfor...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1111/j.1532-5415.1992.tb02024.x

    authors: Stuck AE,van Gorp WG,Josephson KR,Morgenstern H,Beck JC

    更新日期:1992-05-01 00:00:00

  • Apathy: Risk Factor for Mortality in Nursing Home Patients.

    abstract:OBJECTIVES:To determine the prognostic value of apathy for mortality in patients of somatic (SC) and dementia special care (DSC) nursing home (NH) units. DESIGN:Longitudinal design, secondary analyses of a 2-year, cluster-randomized trial with six measurements, approximately 4 months in between. SETTING:SC and DSC-un...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/jgs.15007

    authors: Nijsten JMH,Leontjevas R,Pat-El R,Smalbrugge M,Koopmans RTCM,Gerritsen DL

    更新日期:2017-10-01 00:00:00

  • Biomechanical properties of shoes and risk of falls in older adults.

    abstract:OBJECTIVES:To determine the relationships between the biomechanical properties of shoes worn in a cohort of healthy older adults and the risk of falling. DESIGN:Nested case-control study, comparing biomechanical measurements of shoes worn by those who reported a fall with measurements of shoes worn by age- and sex-mat...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2004.52507.x

    authors: Tencer AF,Koepsell TD,Wolf ME,Frankenfeld CL,Buchner DM,Kukull WA,LaCroix AZ,Larson EB,Tautvydas M

    更新日期:2004-11-01 00:00:00

  • The mental efficiency of the elderly person with type II diabetes mellitus.

    abstract::Cognitive function is often impaired in type I diabetes mellitus, especially when onset is in early childhood. Limited evidence suggests similar impairment in the much larger population of older persons with type II diabetes. We report here the results of 13 measures of mental efficiency in persons between 65 and 77 y...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1990.tb02398.x

    authors: U'Ren RC,Riddle MC,Lezak MD,Bennington-Davis M

    更新日期:1990-05-01 00:00:00

  • Health Heterogeneity in Older Adults: Exploration in the Canadian Longitudinal Study on Aging.

    abstract:BACKGROUND:A widely held dictum in aging research is that heterogeneity in health increases with age, but the basis for this claim has not been fully investigated. We examined heterogeneity at different ages across health characteristics to describe variation and trends; we investigated the comparative importance of be...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16919

    authors: Nguyen QD,Moodie EM,Forget MF,Desmarais P,Keezer MR,Wolfson C

    更新日期:2020-11-05 00:00:00

  • Emerging antidementia drugs: a preliminary ethical view.

    abstract::What ethical concerns regarding the application of new antidementia compounds are pertinent to the best interests of patients with Alzheimer's disease and their caregivers? Based on collected preliminary anecdotal accounts, these concerns are important and should be considered carefully by clinicians, researchers, and...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1998.tb03819.x

    authors: Post SG,Whitehouse PJ

    更新日期:1998-06-01 00:00:00

  • Effect of a high-intensity functional exercise program on functional balance: preplanned subgroup analyses of a randomized controlled trial in residential care facilities.

    abstract:OBJECTIVES:To evaluate whether age, sex, depression, dementia disorder, nutritional status, or level of functional balance capacity influences the effect of a high-intensity functional weight-bearing exercise program on functional balance. DESIGN:Preplanned subgroup analyses of a randomized controlled trial. SETTING:...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1532-5415.2011.03484.x

    authors: Littbrand H,Carlsson M,Lundin-Olsson L,Lindelöf N,Håglin L,Gustafson Y,Rosendahl E

    更新日期:2011-07-01 00:00:00

  • Ten-year effects of the advanced cognitive training for independent and vital elderly cognitive training trial on cognition and everyday functioning in older adults.

    abstract:OBJECTIVES:To determine the effects of cognitive training on cognitive abilities and everyday function over 10 years. DESIGN:Ten-year follow-up of a randomized, controlled single-blind trial (Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE)) with three intervention groups and a no-contact control...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/jgs.12607

    authors: Rebok GW,Ball K,Guey LT,Jones RN,Kim HY,King JW,Marsiske M,Morris JN,Tennstedt SL,Unverzagt FW,Willis SL,ACTIVE Study Group.

    更新日期:2014-01-01 00:00:00