Effects of interferon-beta on plasma lipid and lipoprotein composition and post-heparin lipase activities in patients with chronic hepatitis C.

abstract：:Resistance of Helicobacter pylori to antibiotics included in current regimens used to eradicate H. pylori is a major reason for failure. The definition of resistance is not simple, and the clinical relevance of in vitro results must be considered. The different methods of testing antibiotics cannot apply in all cases....

journal_title：Alimentary pharmacology & therapeutics

authors： Mégraud F

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Mitogen-activated protein (MAP) kinases, including extracellular signal-regulated kinases (ERK),c-Jun NH2-terminal kinases (JNK) and p38 MAP kinase (p38 MAPK) are important intermediates of the signal-transduction pathway from the cell surface to the nucleus. Expression of cyclooxygenase (COX)-2, associated ...

journal_title：Alimentary pharmacology & therapeutics

authors： Tominaga K,Higuchi K,Sasaki E,Suto R,Watanabe T,Fujiwara Y,Oshitani N,Matsumoto T,Kim S,Iwao H,Arakawa T

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:The mechanism of hypergastrinaemia during omeprazole therapy is unclear, but is generally assumed to be entirely a consequence of acid suppression. However, direct stimulation of G cells by omeprazole could also be a factor. In order to further investigate the mechanism of omeprazole-induced hypergastrinaemi...

journal_title：Alimentary pharmacology & therapeutics

authors： Banerjee S,Ardill JE,Beattie AD,McColl KE

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:The presence of active brown adipose tissue (BAT) has been associated with a reduced risk of obesity in adult humans. AIM:To examine whether the presence and activity of BAT in patients undergoing PET-CT examinations is related to the presence of fatty liver. METHOD:We retrospectively analysed 3666 consecu...

journal_title：Alimentary pharmacology & therapeutics

authors： Yilmaz Y,Ones T,Purnak T,Ozguven S,Kurt R,Atug O,Turoglu HT,Imeryuz N

更新日期：2011-08-01 00:00:00

abstract：:The effect of 7 days of oral dosing with 5 mg day-1 and 20 mg day-1 omeprazole on basal and pentagastrin-stimulated gastric acid output was studied in nine duodenal ulcer patients. Basal acid output measured 5-6 h post-dosing was decreased by a mean of 75% on 5 mg omeprazole and by 90% on 20 mg omeprazole (P less than...

journal_title：Alimentary pharmacology & therapeutics

authors： McLauchlan G,Crean GP,McColl KE

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:Phenolphthalein is widely used as a safe and effective laxative. After oral administration, phenolphthalein is absorbed in the small bowel and is conjugated in the liver to phenolphthalein glucuronide which passes into the colon where it is deconjugated and the active compound, phenolphthalein, is released. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Anand BS,Torres E,Operkun A,Graham DY

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Triple therapy currently forms the cornerstone of the treatment of patients with Helicobacter pylori-positive duodenal ulcer. AIM:To establish whether prolonged antisecretory therapy is necessary in patients with active duodenal ulcer. METHODS:A total of 77 patients with H. pylori-positive duodenal ulcer w...

journal_title：Alimentary pharmacology & therapeutics

authors： Tepes B,Krizman I,Gorensek M,Gubina M,Orel I

更新日期：2001-07-01 00:00:00

abstract：INTRODUCTION:With the rising incidence of oesophageal cancer, palliative treatment has an increasingly important role. With median survival unlikely to exceed 6 months, in advanced disease the palliative therapy chosen must not hasten patient's demise. AIM:To establish the outcome of both modern and historical palliat...

journal_title：Alimentary pharmacology & therapeutics

authors： Jethwa P,Lala A,Powell J,McConkey CC,Gillison EW,Spychal RT

更新日期：2005-02-15 00:00:00

abstract：BACKGROUND:Chronic hepatitis C (HCV) treatment with pegylated-interferon (PEG-IFN)/ribavirin (RBV) is often limited by preexisting medical, psychiatric and psychosocial contraindications. However, limited data exist in general patient populations. AIM:To evaluate the percentage of HCV-infected patients in the general ...

journal_title：Alimentary pharmacology & therapeutics

authors： Talal AH,LaFleur J,Hoop R,Pandya P,Martin P,Jacobson I,Han J,Korner EJ

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:There is clear benefit from combination therapy with infliximab and immunosuppressive drugs (IS), but few data are available for adalimumab (ADA). AIM:To assess the efficacy of ADA monotherapy and ADA+IS for induction and maintenance therapy in Crohn's disease. METHODS:Retrospective study of patients with ...

journal_title：Alimentary pharmacology & therapeutics

authors： Reenaers C,Louis E,Belaiche J,Seidel L,Keshav S,Travis S

更新日期：2012-12-01 00:00:00

abstract：AIM:To investigate the incidence of death in patients diagnosed with Crohn's disease in Cardiff over 20 years ago. METHODS:The Cardiff database of patients with Crohn's disease contains data on all patients diagnosed there since 1934. Patients (394) diagnosed before 1 January 1985 were traced and their mortality statu...

journal_title：Alimentary pharmacology & therapeutics

authors： Canavan C,Abrams KR,Hawthorne B,Mayberry JF

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Twice-daily dosing is increasingly used to improve gastric acid control, although not all proton-pump inhibitors are more effective when doses are split. Standard dose esomeprazole provides better gastric acid control than other standard dose proton-pump inhibitors. AIMS:To compare the effect of standard do...

journal_title：Alimentary pharmacology & therapeutics

authors： Hammer J,Schmidt B

更新日期：2004-05-15 00:00:00

abstract：BACKGROUND:With the global efforts to eradicate hepatitis C virus (HCV), treatment during pregnancy is becoming a priority for research as this, and maternal cure should reduce vertical transmission. However, as information on the efficacy and safety of direct-acting antivirals (DAAs) in pregnancy is generally lacking,...

journal_title：Alimentary pharmacology & therapeutics

authors： Freriksen JJM,van Seyen M,Judd A,Gibb DM,Collins IJ,Greupink R,Russel FGM,Drenth JPH,Colbers A,Burger DM

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The mucosa-associated microbiota appears to be highly relevant to host-microbe interactions in the gastrointestinal (GI) tract. Thus, precise characterisation of the mucosa-associated microbiota may provide important insights for diagnostic and therapeutic development. However, for technical reasons, mucosal...

journal_title：Alimentary pharmacology & therapeutics

authors： Shanahan ER,Zhong L,Talley NJ,Morrison M,Holtmann G

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Depression is associated with substantial morbidity and mortality in cirrhosis, but is underdiagnosed and undertreated. AIMS:Using the Mini International Neuropsychiatric Interview (MINI) as a gold-standard, to determine prevalence, predictors, and outcomes of depression, and to develop a screening nomogram...

journal_title：Alimentary pharmacology & therapeutics

authors： Buganza-Torio E,Mitchell N,Abraldes JG,Thomas L,Ma M,Bailey RJ,Tandon P

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Non-cardiac chest pain is one of the most common functional gastrointestinal disorders. By recognising that gastro-oesophageal reflux disease (GERD), oesophageal dysmotility and oesophageal hypersensitivity are the main underlying mechanisms of NCCP, a more directed therapeutic approach has been developed. ...

journal_title：Alimentary pharmacology & therapeutics

authors： George N,Abdallah J,Maradey-Romero C,Gerson L,Fass R

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Combined treatment using an acid-inhibiting drug with antibiotics can cure Helicobacter pylori infection. However, eradication rates are highly variable, especially if a proton pump inhibitor is used with amoxycillin. Therefore it is important to define factors/predictors of the clinical outcome. METHODS:In...

journal_title：Alimentary pharmacology & therapeutics

authors： Treiber G,Ammon S,Klotz U

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:Anti-TNFα agents have revolutionised management of chronic inflammatory diseases. Paradoxically, these agents might provoke development of de novo autoimmune diseases. AIM:To examine whether there is an increased risk of developing Crohn's disease (CD) and ulcerative colitis (UC) while under treatment with ...

journal_title：Alimentary pharmacology & therapeutics

authors： Korzenik J,Larsen MD,Nielsen J,Kjeldsen J,Nørgård BM

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:In vitro studies have shown that pH is an important determinant of mucus structure and function, but the relationship in vivo is unclear. Omeprazole increases intragastric pH and also allows bacterial overgrowth. In this study we have assessed the effect of omeprazole on gastric juice viscosity and examined ...

journal_title：Alimentary pharmacology & therapeutics

authors： Goddard AF,Spiller RC

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:The goal of hepatorenal syndrome type 1 (HRS-1) treatment is to improve renal function. Terlipressin, a synthetic vasopressin analogue, is a systemic vasoconstrictor used for the treatment of HRS-1, where it is available. AIM:To compare the efficacy of terlipressin plus albumin vs. placebo plus albumin in p...

journal_title：Alimentary pharmacology & therapeutics

authors： Sanyal AJ,Boyer TD,Frederick RT,Wong F,Rossaro L,Araya V,Vargas HE,Reddy KR,Pappas SC,Teuber P,Escalante S,Jamil K

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Low bone mineral density (BMD) has been reported in both paediatric and adult patients with non-alcoholic fatty liver disease (NAFLD). The mechanisms behind the reduced BMD in NAFLD are still not completely understood. AIM:To provide a critical overview of the pathophysiological pathways linking NAFLD, redu...

journal_title：Alimentary pharmacology & therapeutics

authors： Yilmaz Y

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Magnetic resonance imaging (MRI) colonography or enterography is increasingly used to assess disease activity and complications in inflammatory bowel disease (IBD). However, no study has evaluated the role of this imaging technique to assess sacroiliitis. AIM:The primary objective was to assess the prevalen...

journal_title：Alimentary pharmacology & therapeutics

authors： Leclerc-Jacob S,Lux G,Rat AC,Laurent V,Blum A,Chary-Valckenaere I,Peyrin-Biroulet L,Loeuille D

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Delta virus (HDV)-related chronic hepatitis is difficult to treat. AIMS:To evaluate the efficacy of lamivudine 100 mg daily on serum HDV-RNA, hepatitis D virus antibodies and alanine aminotransferase levels, liver histology, and on hepatitis B surface antigen seroconversion. METHODS:Thirty-one hepatitis B ...

journal_title：Alimentary pharmacology & therapeutics

authors： Niro GA,Ciancio A,Tillman HL,Lagget M,Olivero A,Perri F,Fontana R,Little N,Campbell F,Smedile A,Manns MP,Andriulli A,Rizzetto M

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Current guidelines recommend the cessation of clopidogrel therapy 5 days and 7-10 days prior to colonoscopic polypectomy. Recent studies have advocated for continued clopidogrel as post-polypectomy bleeding (PPB) rates have been similar to those in the general population not on antithrombotic therapy. AIM:T...

journal_title：Alimentary pharmacology & therapeutics

authors： Gandhi S,Narula N,Mosleh W,Marshall JK,Farkouh M

更新日期：2013-05-01 00:00:00

abstract：:Endoscopic procedures generate bacteraemia to different degrees. Under certain conditions, most notably valvular heart disease, clinically significant infections may occur. A large body of literature has grown around recommendations for antibiotic prophylaxis to prevent procedure-related infections. Most of this liter...

journal_title：Alimentary pharmacology & therapeutics

authors： Schembre D,Bjorkman DJ

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Pneumatic dilation has re-emerged as a first line treatment for achalasia, but conclusions are limited by the relatively small numbers of patients studied and the lack of long term follow-up. AIM:To summarise and analyse 29 available studies evaluating pneumatic dilation for achalasia with focus on efficacy...

journal_title：Alimentary pharmacology & therapeutics

authors： Katzka DA,Castell DO

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Upper gastrointestinal bleeding is a common medical emergency associated with substantial mortality. Tranexamic acid may be effective for reducing mortality in upper gastrointestinal bleeding. AIM:To examine the effects of tranexamic acid in upper gastrointestinal bleeding by systematic review and meta-anal...

journal_title：Alimentary pharmacology & therapeutics

authors： Twum-Barimah E,Abdelgadir I,Gordon M,Akobeng AK

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Data on tenofovir alafenamide fumarate (TAF) for preventing mother-to-child transmission of hepatitis B virus (HBV) are lacking. AIMS:To investigate the efficacy and safety of TAF therapy for preventing hepatitis B mother-to-child transmission. METHODS:Mothers with chronic HBV infection, positive for hepat...

journal_title：Alimentary pharmacology & therapeutics

authors： Ding Y,Cao L,Zhu L,Huang Y,Lin C,Wang Y,Liu Y,Sheng Q,Wang S,Fan J,Chen R,Gan W,Chen B,Pan CQ

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Capsule endoscopy can identify lesions of the small bowel that cannot be detected by other techniques. In addition to patient safety, quality of care and cost-efficiency, good preparation is an important factor for good visualization. AIM:To evaluate the efficacy of oral sodium phosphate preparation. METHO...

journal_title：Alimentary pharmacology & therapeutics

authors： Niv Y,Niv G,Wiser K,Demarco DC

更新日期：2005-11-15 00:00:00

abstract：BACKGROUND:In average-risk patients, the new anti-platelet agent, clopidogrel, causes less upper gastrointestinal adverse events than aspirin. However, there are no safety data on the use of clopidogrel in high-risk patients. AIM:To evaluate the safety of clopidogrel in patients with peptic ulcer disease in a retrospe...

journal_title：Alimentary pharmacology & therapeutics

authors： Ng FH,Wong SY,Chang CM,Chen WH,Kng C,Lanas AI,Wong BC

更新日期：2003-08-15 00:00:00