Abstract:
:1,4-Oxazepine formation reactions of 1,8-naphthyridine derivatives (1-4) with peroxy acid have been studied using a semiempirical MO method (AM1) and an ab initio molecular orbital method (Gaussian 94). The energies of molecules involved in the reaction paths were calculated and the transition states related to experimental products were obtained. For the reactions of 1-3, the calculated energies of the transition states predicted the previously obtained products. However, the calculated values for the reaction of 4 suggested a different type of oxazepine compound, which was verified in further experiments.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Matsuzaki H,Takeuchi I,Hamada Y,Hatano Kdoi
10.1248/cpb.48.755subject
Has Abstractpub_date
2000-05-01 00:00:00pages
755-6issue
5eissn
0009-2363issn
1347-5223journal_volume
48pub_type
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