Abstract:
:The permeability of nalmefene hydrochloride (NH) across different regions of ovine nasal mucosa was investigated in vitro. Five different regions of ovine nasal mucosa (superior turbinate mucosa, middle turbinate mucosa, inferior turbinate mucosa, posterior septum mucosa, and anterior septum mucosa) were studied. The results showed that the permeability coefficients of NH through different regions of nasal mucosa were different, and the suitable regions for the absorption of NH were the middle turbinate mucosa, the posterior septum mucosa and the superior turbinate. At the same time, the middle turbinate mucosa was the largest region among the five regions, thus it was the main absorption region for NH. The high uniformity of the middle turbinate mucosa also made it the most suitable model for the permeation of NH in vitro.
journal_name
Chem Pharm Bull (Tokyo)journal_title
Chemical & pharmaceutical bulletinauthors
Du G,Gao Y,Nie S,Pan Wdoi
10.1248/cpb.54.1722subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1722-4issue
12eissn
0009-2363issn
1347-5223pii
JST.JSTAGE/cpb/54.1722journal_volume
54pub_type
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journal_title:Chemical & pharmaceutical bulletin
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journal_title:Chemical & pharmaceutical bulletin
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更新日期:2001-03-01 00:00:00
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更新日期:2011-01-01 00:00:00