Abstract：
:The present review discusses the history and paradigm of the conditioned avoidance response (CAR) in rats for the detection of potential antipsychotic activity of drugs. In addition, the role of dopamine (DA) D2, serotonin (5-HT)2A/2C, alpha1, 5-HT1A, DA D4, muscarinic and glutamate receptors in the suppression of CAR induced by various classes of drugs is evaluated. Finally, data investigating brain sites of action for the mediation of CAR behavior is discussed. It is concluded that the CAR test, originally found to be sensitive for the detection of antipsychotic drugs with high affinity as antagonists for brain dopamine receptors, is also sensitive for the detection of potentially antipsychotic compounds acting primarily via neurotransmitter receptors other than the DA D2 receptor. Furthermore, the review confirms the importance of the nucleus accumbens(shell) in the mediation of effects on CAR produced by traditional, as well as atypical antipsychotic drugs.
journal_name
Neurosci Biobehav Revjournal_title
Neuroscience and biobehavioral reviewsauthors
Wadenberg ML,Hicks PBdoi
10.1016/s0149-7634(99)00037-8subject
Has Abstractpub_date
1999-01-01 00:00:00pages
851-62issue
6eissn
0149-7634issn
1873-7528pii
S0149763499000378journal_volume
23pub_type
杂志文章,评审abstract：:The adaptive control of behaviour in response to relevant external objects and events often requires the selection of information delivered by different sensory systems, but from the same region in external space. This can be facilitated by crossmodal links in the attentional processing of information across sensory m...
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journal_title：Neuroscience and biobehavioral reviews
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