Abstract:
:Interleukin-1 (IL-1) and tumor necrosis factor (TNF) are immunoregulatory cytokines that mediate many aspects of the acute phase response to infection and injury. It has been hypothesized that these cytokines mediate the onset of the cachexia-anorexia syndrome with tumor growth. The anorexigenic effects of IL-1 are mediated in part by prostaglandins (PG). Therefore, the purpose of the present study was to determine if administration of ibuprofen (ibu) or indomethacin (indo), which inhibit PG synthesis, would affect the food intake and body weight of tumor-bearing rats. Rats were implanted with the Morris 7777 hepatoma, a tumor known to induce anorexia and weight loss in rats, and weight loss and leukocyte synthesis of IL-1 and TNF in mice. Treatment with indo or ibu did not improve food intake or body weight in the tumor-bearing rats. However, administration of ibu coincident with tumor implantation did result in smaller tumor mass compared to placebo-treated controls. The results of the present study suggest that PG synthesis is not a major factor in the onset of anorexia in this animal model of tumor-induced anorexia. However, further studies of the effects of inhibitors of PG synthesis on the kinetics of tumor growth are clearly indicated.
journal_name
Res Nurs Healthjournal_title
Research in nursing & healthauthors
McCarthy DOdoi
10.1002/(sici)1098-240x(199910)22:5<380::aid-nur4>subject
Has Abstractpub_date
1999-10-01 00:00:00pages
380-7issue
5eissn
0160-6891issn
1098-240Xpii
10.1002/(SICI)1098-240X(199910)22:5<380::AID-NUR4>journal_volume
22pub_type
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journal_title:Research in nursing & health
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journal_title:Research in nursing & health
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journal_title:Research in nursing & health
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journal_title:Research in nursing & health
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