Abstract:
:Skeletal muscle wasting is a prominent feature of cancer cachexia and involves decreased muscle protein synthesis and increased activity of the ubiquitin-proteasome pathway of protein degradation. We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice. Ibuprofen increased the soluble protein content of the muscle without affecting muscle levels of phosphorylated p70 S6 kinase, a ribosomal kinase involved in protein synthesis. Paradoxically, indomethacin increased levels of ubiquitin-conjugated proteins. Further study is needed to understand the mechanism of action by which indomethacin and ibuprofen preserve body weight and muscle mass in the tumor-bearing mice. The data suggest that ibuprofen may have beneficial effects in the treatment of cancer cachexia.
journal_name
Res Nurs Healthjournal_title
Research in nursing & healthauthors
McCarthy DO,Whitney P,Hitt A,Al-Majid Sdoi
10.1002/nur.20019subject
Has Abstractpub_date
2004-06-01 00:00:00pages
174-84issue
3eissn
0160-6891issn
1098-240Xjournal_volume
27pub_type
杂志文章abstract::The aim of this analysis was to identify the association between incontinence-associated dermatitis (IAD), its most important etiologic factors (incontinence and moisture), and pressure ulcers (PUs). A systematic review and meta-analysis were performed. We searched Medline, Embase, CINAHL, Web of Science, and the Coch...
journal_title:Research in nursing & health
pub_type: 杂志文章,meta分析,评审
doi:10.1002/nur.21593
更新日期:2014-06-01 00:00:00
abstract::The development and testing of a multidimensional instrument to assess the reactions of family members caring for elderly persons with physical impairments, Alzheimer's disease, and cancer is reported. Forty items were administered to a sample of 377 caregivers of persons with physical impairments and Alzheimer's dise...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.4770150406
更新日期:1992-08-01 00:00:00
abstract::Registered nurses (N = 323) working in a 500-bed tertiary care hospital in a large midwestern city were surveyed to determine what and how they initially learned about the medical devices they use, and the consequences of their use. The most frequently identified methods of initial learning were trial and error (taugh...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.4770180209
更新日期:1995-04-01 00:00:00
abstract::We conducted a cross-sectional study to examine sleep in mothers of children with epilepsy and its relation to their children's sleep. A total of 133 dyads of mothers and children with epilepsy aged 1.5-6 years were recruited between 2015 and 2018 from a children's hospital in northern Taiwan. Participating families p...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.22008
更新日期:2020-04-01 00:00:00
abstract::The purpose of this study was to determine the effect of intensity controlled exercise on the aerobic capacity of overweight, middle-aged women. Thirty-eight moderately overweight women, ages 35-57, participated in a 16-week dance-exercise program. Random assignment was made to an experimental group (n = 20) in which ...
journal_title:Research in nursing & health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/nur.4770100606
更新日期:1987-12-01 00:00:00
abstract::The purpose of the study was to determine if the tensing portion of progressive relaxation initiates the Valsalva response in order to establish the safety of the procedure for acutely ill cardiovascular patients. Sixty healthy adult volunteers performed fist, chest, and abdominal tensing and relaxation while their he...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.4770100309
更新日期:1987-06-01 00:00:00
abstract::In hospitals, nurses provide patient care around the clock, but the impact of night staff characteristics on patient outcomes is not well understood. The aim of this study was to examine the association between night nurse staffing and workforce characteristics and the length of stay (LOS) in 138 veterans affairs (VA)...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.21582
更新日期:2014-04-01 00:00:00
abstract::To determine the extent to which social support from the spouse and a health care provider (HCP) is associated with short- and long-term recovery outcomes in individuals after a cardiac illness, 93 patients were interviewed 2 months (short-term) after their event; 73 (78%) subjects responded to a follow-up questionnai...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.4770180303
更新日期:1995-06-01 00:00:00
abstract::A survey of 156 female undergraduate nursing students was conducted to determine the relationship between life change events and dysmenorrhea and the mediating effect of social supports on this relationship. Data were collected using the Anderson College Schedule of Recent Experience (subjects estimated personal readj...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.4770050207
更新日期:1982-06-01 00:00:00
abstract::Recent studies have identified common problems with patient safety in hospitals and medical institutions have responded, prioritizing service quality and performance, including patient safety. However, the factors influencing safety for hospital patients are still being examined and clarified. We aimed to investigate ...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.22067
更新日期:2020-09-01 00:00:00
abstract::Measures of the quality of hospital postnatal nursing care were developed for an evaluative study of the benefits of combined mother-infant versus traditional separate staffing patterns. Two hundred mothers completed instruments designed to measure maternal competence, patient satisfaction, establishment of breast-fee...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.4770120505
更新日期:1989-10-01 00:00:00
abstract::We examined African American women's representations/beliefs about mental illness, preferred coping behaviors if faced with mental illness, whether perceived stigma was associated with treatment-seeking, and if so, whether it was related to beliefs and coping preference, and whether these variables differed by age gro...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.20344
更新日期:2009-10-01 00:00:00
abstract::The aims of this study were to adapt the Body Image Quality of Life Inventory (BIQLI) into Brazilian Portuguese (BP) and to assess the psychometric properties of the adapted version. Construct validity was assessed by correlating the BIQLI-BP scores with the Rosenberg's Self-Esteem Scale, with Burns Specific Health Sc...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.21538
更新日期:2013-06-01 00:00:00
abstract::The purpose of the study was to develop four questionnaires based on the transtheoretical model (TTM) to assess the behavior, completing a healthcare proxy (HCP). The aims were to (a) operationalize the four TTM constructs for completing a HCP and (b) evaluate the psychometric properties of the questionnaires. The que...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.20352
更新日期:2009-12-01 00:00:00
abstract::Postpartum depression (PPD) is recognized as a common maternal health problem, but few studies have investigated the postpartum mental health of refugee women. In this cross-sectional study, we investigated the prevalence of PPD symptoms and associated factors among Syrian refugee women living in north Jordan. Women (...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.21919
更新日期:2018-12-01 00:00:00
abstract::The analysis of covariance (ANCOVA) is a powerful analytic tool, but there continue to be abuses of the method. We review assumptions and illustrate legitimate uses of ANCOVA, and summarize statistical packages' approach to the method. Finally, we consider how ANCOVA is used in contemporary nursing research. ...
journal_title:Research in nursing & health
pub_type: 杂志文章,评审
doi:10.1002/(sici)1098-240x(199812)21:6<557::aid-nur9>
更新日期:1998-12-01 00:00:00
abstract::Over a quarter of chemotherapy regimens now include oral agents. Individuals living with cancer are now responsible for administering this lifesaving therapy at home by taking every dose as prescribed. One type of oral chemotherapy, tyrosine kinase inhibitors (TKIs), is the current recommended treatment for chronic my...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.22069
更新日期:2020-09-01 00:00:00
abstract::The investigators aimed to explore the prevalence of depressive symptoms and associated factors among older residents with intact cognitive function in nursing homes in Taiwan. A cross-sectional descriptive and correlational research design was used. A convenience sample of 178 older residents without cognitive impair...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.21873
更新日期:2018-06-01 00:00:00
abstract::Intrauterine growth retardation (IUGR) is an overlooked problem in full-term infants with birth weights greater than 2,500 g. Birth weight less than the 10th percentile underestimates the presence of IUGR. The purpose of this study was to determine the prevalence of IUGR in full-term infants and to identify sociodemog...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.20044
更新日期:2004-12-01 00:00:00
abstract::Running motivated by an addictive mechanism may overpower the sensible, beneficial approach to exercise. Neglect of family responsibilities and relationships may occur as a result of this addiction. Thirty-five marathon runners and their spouses were studied; 22 of the runners were women and 13 were men. Each runner a...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.4770130404
更新日期:1990-08-01 00:00:00
abstract::Little is known about how cancer patients manage the side effects of chemotherapy, so 48 cancer patients in chemotherapy were randomized into four groups to determine their self-care behaviors. The first group received drug information only; the second group received information on side-effect management techniques (S...
journal_title:Research in nursing & health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/nur.4770070108
更新日期:1984-03-01 00:00:00
abstract::In this paper three categories of variables were identified to predict spouses' reactions to caregiving roles: patient characteristics, the caregiving environment, and characteristics of the caregiver. Measures of these variables were administered to 159 spouse caregivers. Four domains of caregivers' responses were id...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.4770130204
更新日期:1990-04-01 00:00:00
abstract::A meta-analysis was conducted to quantify the impact of exercise interventions on the functional status of older adults. Searches of Medline and CINAHL databases revealed 19 randomized controlled trials reporting 30 interventions (n = 2,201). Fixed- and random-effects models were used to estimate overall mean effect s...
journal_title:Research in nursing & health
pub_type: 杂志文章,meta分析
doi:10.1002/nur.20290
更新日期:2008-12-01 00:00:00
abstract::We examined the relationship between sexual assault and gynecological health symptoms (e.g., pelvic pain, painful intercourse) in a sample of predominately African American female veterans. Those who had been sexually victimized experienced significantly more frequent gynecological health symptoms than those who had n...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.20155
更新日期:2006-10-01 00:00:00
abstract::A predictive model of well-being and self-care was tested with 284 women aged 60-88 living in rural communities in Taiwan. The variables studied were age, marital status, social class, social support, perceived health, self-care agency, self-care behavior, and perceived well-being. The model was tested by path analysi...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.1015
更新日期:2001-04-01 00:00:00
abstract::Bereaved, property loss, and control groups (N = 155) studied 11 months following the 1980 volcanic eruption of Mt. St. Helens were recontacted 35 months postdisaster to test the hypotheses that the greater the loss experienced, the higher the stress, and the poorer the health. In general, the hypotheses were supporte...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.4770090410
更新日期:1986-12-01 00:00:00
abstract::Anger expression modes were examined in a diverse sample of mid-life men and women (N = 139) participating in the third phase of a longitudinal study of health that began in 1982 at the World's Fair and a metropolitan general hospital in Tennessee. Contrary to previous studies, men and women did not differ in the like...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.4770120609
更新日期:1989-12-01 00:00:00
abstract::The purpose of this study was to analyze and compare the recorded content of two experimental nursing interventions used in a hypertensive-education program. One intervention was characterized as deliberative or high indirect, the other as task-centered or low indirect. A total of 4,149 nurse-patient interaction units...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.4770060103
更新日期:1983-03-01 00:00:00
abstract::We tested a theoretical model of the relationships of hospital context, nursing unit structure, and patient characteristics to patients' perceptions of the extent to which nurses met their expectations for management of troubling symptoms. In our sample of 2,720 patients randomly selected from 278 nursing units in 143...
journal_title:Research in nursing & health
pub_type: 杂志文章
doi:10.1002/nur.20319
更新日期:2009-06-01 00:00:00
abstract::School age children, 8 to 12 years old (N = 103), reported on the strategies they use to help them deal with stressors. Individual questionnaires contained 518 coping strategies that were sorted into 13 categories inductively derived from the content of the behaviors. Girls named significantly more social support and ...
journal_title:Research in nursing & health
pub_type: 杂志文章,评审
doi:10.1002/nur.4770120208
更新日期:1989-04-01 00:00:00