Abstract：
:Over a quarter of chemotherapy regimens now include oral agents. Individuals living with cancer are now responsible for administering this lifesaving therapy at home by taking every dose as prescribed. One type of oral chemotherapy, tyrosine kinase inhibitors (TKIs), is the current recommended treatment for chronic myeloid leukemia. This targeted therapy has markedly improved survival but comes with significant side effects and financial costs. In the study described in this protocol, the investigators seek to understand the dynamic nature of TKI adherence experienced by individuals diagnosed with CML. Using a mixed-method approach in this prospective observational study, funded by the National Cancer Institute, we seek to describe subjects' adherence trajectories over 1 year. We aim to characterize adherence trajectories in individuals taking TKIs using model-based cluster analysis. Next, we will determine how side effects and financial toxicity influence adherence trajectories. Then we will examine the influence of TKI adherence trajectories on disease outcomes. Additionally, we will explore the experience of patients taking TKIs by interviewing a subset of participants in different adherence trajectories. The projected sample includes 120 individuals taking TKIs who we will assess monthly for 12 months, measuring adherence with an objective measure (Medication Event Monitoring System). Identifying differential trajectories of adherence for TKIs is important for detecting subgroups at the highest risk of nonadherence and will support designing targeted interventions. Results from this study can potentially translate to other oral agents to improve care across different types of cancer.
journal_name
Res Nurs Healthjournal_title
Research in nursing & healthauthors
Yeager KA,Waldrop-Valverde D,Paul S,Bruner DW,Klisovic R,Burns E,Mason TA,Patel N,Jennings BMdoi
10.1002/nur.22069subject
Has Abstractpub_date
2020-09-01 00:00:00pages
443-452issue
5eissn
0160-6891issn
1098-240Xjournal_volume
43pub_type
杂志文章abstract：:The aim of this study was to test a theoretical model of the facilitators and barriers to physical activity for Taiwanese adults with anxiety. Structural equation modeling was used to examine both one-way direct and indirect influences of 11 personal and cognitive-emotional factors on physical activity in this populat...
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