HLA characterization in adult asymptomatic cyst passers of Entamoeba histolytica/E. dispar.

Abstract:

:The present work aimed at studying the possible association of HLA antigens with Entamoeba histolytica/E. dispar asymptomatic infection in a Mexican mestizo population. A case-control design was selected for evaluation of the role of genetic markers in parasite infection. For this purpose the HLA-A, HLA-B, and HLA-DR profiles of a population of asymptomatic E. histolytica/E. dispar adult cyst passers (cases) and a corresponding nonparasitized adult group (controls) followed for 12 months were identified. Entamoeba species were identified through zymodeme patterns and/or amplification of species-specific DNA sequences. A healthy, nonparasitized group of individuals was included as a control. Our results show that apparently, no specific HLA marker is associated with the asymptomatic cyst passers' condition. These findings have to be added to previous results in which, in contrast to a demonstrated association between HLA-DR3 and amebic liver abscess in Mexican mestizo adults and infants, no significant association with amebic rectocolitis was found.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Valdez E,del Carmen Martínez M,Gómez A,Cedillo R,Arellano J,Pérez ME,Ramos F,Morán P,González E,Valenzuela O,Melendro EI,Ramiro M,Kretschmer R,Muñoz O,Ximénez C

doi

10.1007/s004360050641

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

833-6

issue

10

eissn

0932-0113

issn

1432-1955

journal_volume

85

pub_type

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