Abstract:
:The present work aimed at studying the possible association of HLA antigens with Entamoeba histolytica/E. dispar asymptomatic infection in a Mexican mestizo population. A case-control design was selected for evaluation of the role of genetic markers in parasite infection. For this purpose the HLA-A, HLA-B, and HLA-DR profiles of a population of asymptomatic E. histolytica/E. dispar adult cyst passers (cases) and a corresponding nonparasitized adult group (controls) followed for 12 months were identified. Entamoeba species were identified through zymodeme patterns and/or amplification of species-specific DNA sequences. A healthy, nonparasitized group of individuals was included as a control. Our results show that apparently, no specific HLA marker is associated with the asymptomatic cyst passers' condition. These findings have to be added to previous results in which, in contrast to a demonstrated association between HLA-DR3 and amebic liver abscess in Mexican mestizo adults and infants, no significant association with amebic rectocolitis was found.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Valdez E,del Carmen Martínez M,Gómez A,Cedillo R,Arellano J,Pérez ME,Ramos F,Morán P,González E,Valenzuela O,Melendro EI,Ramiro M,Kretschmer R,Muñoz O,Ximénez Cdoi
10.1007/s004360050641subject
Has Abstractpub_date
1999-10-01 00:00:00pages
833-6issue
10eissn
0932-0113issn
1432-1955journal_volume
85pub_type
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