Molecular approaches towards the isolation of sleep-related genes.

Abstract:

:Behavioural genetics is one of the most enticing fields in modern biology. Owing to straightforward and semiautomated techniques that can be used to measure locomotor activity, circadian rhythmicity is perhaps the best studied behaviour in animals. Thus, during the past decade, five essential circadian clock genes have been isolated in Drosophila, and homologous counterparts for all of these genes have also been found in mammals. As the sleep-wake cycle is under the control of the circadian clock, these circadian master genes are expected to influence sleeping behaviour. However, different vigilance states are regulated by additional mechanisms that also have a genetic basis. In this article we discuss molecular approaches that may prove useful in the search for sleep-related genes.

journal_name

J Sleep Res

authors

Schibler U,Tafti M

doi

10.1046/j.1365-2869.1999.00001.x

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

1-10

eissn

0962-1105

issn

1365-2869

journal_volume

8 Suppl 1

pub_type

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