Abstract:
OBJECTIVES:To determine the importance of world region of birth as a risk factor for HIV-1 infection, the likelihood of having an HIV-1 infection diagnosed and the likelihood of having another coexisting acute sexually transmitted infection (STI) among attenders at genitourinary medicine clinics. SUBJECTS:Specimens from attenders having routine syphilis serology at 15 sexually transmitted disease clinics in England, Wales, and Northern Ireland participating in the unliked anonymous seroprevalence monitoring programme from 1994 to 1996. METHODS:Limited data were collected with specimens that were irreversibly unlinked from the source patients before testing for antibodies to HIV-1. Numbers of specimens, the prevalence of HIV-1, the proportions of infections clinically diagnosed, and the presence of coexisting acute STIs were analysed according to world region of birth, sexual orientation, and injecting drug use. RESULTS:Between 1994 and 1996, 173,075 specimens were collected; 16.9% were from people born outside the United Kingdom. Risk of being HIV-1 positive was significantly higher overall for both men and women born abroad, but this was not the case for those born in south Asia (India, Pakistan, and Bangladesh). Homosexual and bisexual males born abroad were almost twice as likely to be HIV infected as their counterparts born in the United Kingdom. However, homosexual and bisexual men born in the United Kingdom accounted for almost three quarters of the 1174 HIV-1 positive specimens detected. Among 158,728 non-drug injecting heterosexuals the highest prevalence was observed in specimens from those men (4.0%) and women (5.8%) born in sub-Saharan Africa. The 6991 heterosexual men and women born in other European countries were also more likely to provide HIV-1 positive specimens than UK born heterosexuals. However, 39% of the HIV-1 positive specimens in heterosexuals come from clinic attenders born in the United Kingdom. Heterosexual males were generally less likely to have their infection diagnosed than females. There were 182 attendances (mostly from London clinics) non-drug injecting heterosexual men and women who were infected with both HIV-1 and an acute sexually transmitted infection; only 12% of whom had had their HIV-1 infection diagnosed. CONCLUSION:Among most people attending genitourinary medicine clinics, being born abroad is associated with an increased likelihood for HIV-1 infection. HIV-1 infected heterosexuals, of whom 46% are people from sub-Saharan Africa, are unlikely to have their infection clinically diagnosed and thus are unable to obtain appropriate treatment. The presence of HIV-1 infected heterosexual men and women with acute STI represents a potential source of heterosexual HIV transmission both for those born in the United Kingdom and born abroad.
journal_name
Sex Transm Infectjournal_title
Sexually transmitted infectionsauthors
McGarrigle CA,Nicoll Adoi
10.1136/sti.74.6.415subject
Has Abstractpub_date
1998-12-01 00:00:00pages
415-20issue
6eissn
1368-4973issn
1472-3263journal_volume
74pub_type
杂志文章abstract:BACKGROUND:In settings with poor sexually transmitted infection (STI) control in high-risk groups, periodic presumptive treatment (PPT) can quickly reduce the prevalence of genital ulcers, Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT). However, few studies have assessed the impact on HIV. Mathematical model...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2008.034678
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of sexual dysfunction and dissatisfaction (SD) among new heterosexual attendees at a central London genitourinary medicine (GUM) clinic. METHODS:Consecutive new attendees seen by a single clinician were asked a probe question about SD in the previous year. A clinical interview fol...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.76.3.208
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:Trichomoniasis vaginalis is a risk factor for the acquisition and transmission of HIV. The objective of this study was to determine the prevalence of T vaginalis (using culture) among HIV-infected women receiving gynaecological care at an university HIV clinic in Alabama in addition to predictors of infection...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2012-050889
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:HIV transmission is ongoing among men who have sex with men (MSM) in the UK. Sex without a condom (condomless sex, CLS) is the main risk factor. We investigated the prevalence of and factors associated with types of CLS. METHODS:Cross-sectional questionnaire study in UK HIV clinics in 2011/2012 (ASTRA). MSM ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sextrans-2016-053029
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To determine the characteristics of general practitioners (GPs) who test and patients who are tested for HIV in Australia. DESIGN AND SETTING:A secondary analysis of data from the Bettering the Evaluation and Care of Health programme; a cross-sectional, national survey of GP activity. METHODS:We identified ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2011.049601
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Genital herpes (GH) is a common sexually transmitted infection. Novel tools for the control of GH (for example, tests and vaccines) are emerging, but optimal assessment of the cost effectiveness of such interventions requires scaled, preference based estimates of the impact of GH on health related quality of...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2004.011619
更新日期:2005-06-01 00:00:00
abstract:OBJECTIVE:From December 2017, the Australian National Cervical Screening Program commenced 5 yearly primary human papillomavirus (HPV) screening; one of the first high-income countries to implement primary HPV screening. This study aimed to examine the psychosocial impact of self-reporting testing HPV positive in a sam...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2019-054290
更新日期:2020-05-01 00:00:00
abstract::In Asia Pacific, most countries have expanded HIV treatment guidelines to include all those with HIV infection and adopted antiretroviral treatment for prevention (TFP) as a blanket strategy for HIV control. Although the overall epidemic development associated with this focus is positive, the HIV epidemic in men who h...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sextrans-2016-052669
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVES:To measure prevalence of selected sexually transmitted infections (STI) and HIV among female sex workers (SWs) in the red light area of Surat, India, and to evaluate the performance of STI syndrome guidelines (for general population women in India) in this group against the standard aetiological diagnosis of...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.79.2.111
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVES:To collect and analyse published and unpublished surveillance and research data on the prevalence of same sex sexual activity among male adults (including male-to-female transgenders and sex workers) in low and middle income countries. METHODS:Key indicators were operationalised (ever sex with a man, sex wi...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sti.2005.019489
更新日期:2006-06-01 00:00:00
abstract::The distribution of HIV-1 subtypes in a population tracks the spread and evolution of the epidemic. This study is a systematic review of all available evidence on HIV-1 molecular epidemiology and subtype distribution in the Middle East and North Africa. Sources of data included Medline and various institutional docume...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sti.2010.043711
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:Young women in sub-Saharan Africa are at high risk of STIs and unintended pregnancies, yet hormonal contraceptive (HC) use may affect STI risk. We compared the influence of three HCs on the incidence and prevalence of STIs and bacterial vaginosis (BV) in South African adolescents. METHODS:One hundred and th...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2020-054483
更新日期:2020-09-28 00:00:00
abstract:OBJECTIVES:To identify the changes in sexual behaviour that led to the dramatic reduction in the prevalence of HIV in Uganda in the early 1990s. METHODS:Seven different types of evidence were examined: (1) models of HIV prevalence and incidence in Kampala and other sentinel sites in Uganda; (2) reports of behaviour ch...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2008.029892
更新日期:2008-10-01 00:00:00
abstract::The number of cases of syphilis continues to rise in the UK, USA and elsewhere and may present to a variety of clinical specialties. We report a complex case of early acquired disseminated syphilis causing an ulceronodular rash (lues maligna), orchitis, osteitis and lung nodules in an immunocompetent man who has sex w...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2017-053508
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:To identify risk factors for pelvic inflammatory disease (PID) in female students. METHODS:We performed a prospective study set in 11 universities and 9 further education colleges in London. In 2004-2006, 2529 sexually experienced, multiethnic, female students, mean age 20.8 years, provided self-taken vagina...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sextrans-2015-052063
更新日期:2016-02-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of rectal chlamydia infection in a cohort of men who have sex with men (MSM) and the proportion of infection that would be missed without routine screening. METHODS:MSM presenting to four HIV/GUM outpatient clinics at the Chelsea & Westminster Hospital NHS Foundation Trust between...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2008.031773
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:WHO estimates that 131 million new cases of urogenital Chlamydia trachomatis (CT) infections occur globally every year. Most infections are asymptomatic. Untreated infection in women can lead to severe complications. Screening and treatment of at-risk populations is a priority for prevention and control. OB...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,评审
doi:10.1136/sextrans-2016-053067
更新日期:2017-12-01 00:00:00
abstract::In the absence of aetiological tests for the diagnosis of individual sexually transmitted diseases (STD), the syndromic approach has been developed as an effective and appropriate case management strategy. Algorithms provide guidance to healthcare workers and ensure standardised approaches to case management. The synd...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVES:Macrolide resistance in Mycoplasma genitalium is emerging globally. There is paucity of data from sub-Saharan Africa where syndromic management is used to treat sexually transmitted infections (STIs). We conducted a molecular epidemiological study to determine the prevalence of azithromycin resistance and ep...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2019-054371
更新日期:2020-05-10 00:00:00
abstract:OBJECTIVES:In 2006, a new variant of Chlamydia trachomatis (nvCT) was reported in Sweden. Because of a cryptic plasmid deletion, the nvCT was undetectable in several of the genetic diagnostic systems used worldwide at the time. This study aimed to evaluate whether the nvCT was present in specimens obtained from patient...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2013-051018
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to assess the prevalence of ciprofloxacin-resistant gonorrhoea in two South African cities and to investigate the association between the isolation of ciprofloxacin-resistant Neisseria gonorrhoeae and the HIV serostatus of patients. METHODS:Gonococci were cultured from endo...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2007.029611
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:To identify prevalence and risks factors for syphilis and HIV among rural female sex workers (FSWs) in Cambodia and to describe differences between rural and urban FSWs. METHODS:Interviews and sera were collected from 114 FSWs and tested for HIV using the Serodia-HIV test and positives confirmed with the enz...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.79.4.e2
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVES:To assess changes in seroadaptive behaviours among men who have sex with men (MSM) in San Francisco over the past 4 years. METHODS:461 MSM were recruited in 2008 as the second wave of the US National HIV Behavioural Surveillance (NHBS) survey in San Francisco. Participants were classified into patterns of s...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2010.042986
更新日期:2011-03-01 00:00:00
abstract:STUDY DESIGN:This study investigated whether access to genitourinary medicine (GUM) clinics meets UK-recommended standards. METHODS:In January 2014 and 2015, postal questionnaires about appointment and service characteristics were sent to lead clinicians of UK GUM clinics. In February 2014 and 2015, researchers posing...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2016-052882
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:We aimed to investigate how an infection with Chlamydia trachomatis (CT) influenced patients' well-being and whether there were differences due to gender, age or relationship status, in an effort to strengthen preventive measures and provide better healthcare for patients with CT. METHODS:Patients diagnosed...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sextrans-2017-053229
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence of urethritis pathogens amongst male symptomatic urethritis (MUS) patients, genital ulcer (GUS) patients without urethritis symptoms and men requesting HIV testing at a voluntary counselling and testing (VCT) clinic. METHODS:A prospective study was conducted in Johannesburg, Sout...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2007.028464
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVES:Herpes simplex virus (HSV) infections in newborns are an uncommon but potentially devastating consequence of genital HSV infection in women. Current practice focuses on preventing perinatal transmission by women with prevalent HSV, but transmission risk is greatest when genital HSV is acquired for the first ...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.2010.045559
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To describe the impact of HIV on mortality in men and women aged 15-54 in London. DESIGN:Combination of routine mortality statistics with reports of AIDS deaths adjusted for underreporting and change in address from time of report to time of death. Calculation of standardised mortality ratios (SMRs) for male...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.75.6.385
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVES:To assess the feasibility and utility of sentinel laboratory surveillance of HIV testing as a tool for understanding patterns and trends in HIV testing in a range of healthcare services. METHODS:Data on all anti-HIV antibody tests carried out by the Leeds Teaching Hospital Trust laboratory over a 12-month p...
journal_title:Sexually transmitted infections
pub_type: 杂志文章,多中心研究
doi:10.1136/sti.2009.041293
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:To describe the epidemiology of type specific recurrent genital herpes, and to compare the duration of recurrent genital lesions caused by herpes simplex virus (HSV) types 1 and 2. METHODS:Participants were enrolled at clinics across the United States. Adults suspected of having active genital herpes were e...
journal_title:Sexually transmitted infections
pub_type: 杂志文章
doi:10.1136/sti.79.6.456
更新日期:2003-12-01 00:00:00