Projected cost-savings with herpes simplex virus screening in pregnancy: towards a new screening paradigm.

Abstract:

OBJECTIVES:Herpes simplex virus (HSV) infections in newborns are an uncommon but potentially devastating consequence of genital HSV infection in women. Current practice focuses on preventing perinatal transmission by women with prevalent HSV, but transmission risk is greatest when genital HSV is acquired for the first time late in pregnancy. The objective of this study was to assess the effectiveness and cost effectiveness of identifying pregnant women at risk of de novo HSV acquisition as a means of preventing vertical HSV transmission. METHODS:A Bayesian decision tree model was parameterized using the best available health and economic data relating to HSV in pregnancy and was used to evaluate the cost effectiveness of screening to identify individuals susceptible to HSV infection in a hypothetical cohort of 100,000 pregnant women in their second trimester of pregnancy. Final outcomes were the projected incidence of maternal and neonatal HSV, quality-adjusted life expectancy and life-time costs associated with neonatal HSV. RESULTS:In the absence of testing, model projected incidence of neonatal HSV was 34 cases per 100,000 births, similar to available surveillance data. Screening pregnant women and their partners was projected to decrease the incidence of HSV-1 and HSV-2 infections in women and infants and to save costs. These findings were robust under alternative assumptions and in wide-ranging sensitivity analyses. CONCLUSIONS:The use of accurate and relatively inexpensive serological tests for HSV to identify women vulnerable to incident HSV infection in pregnancy has the potential to reduce neonatal HSV incidence and reduce health-related costs.

journal_name

Sex Transm Infect

authors

Tuite AR,McCabe CJ,Ku J,Fisman DN

doi

10.1136/sti.2010.045559

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

141-8

issue

2

eissn

1368-4973

issn

1472-3263

pii

sti.2010.045559

journal_volume

87

pub_type

杂志文章
  • What is the overlap between HIV and shigellosis epidemics in England: further evidence of MSM transmission?

    abstract:BACKGROUND:Evidence suggests that sexual transmission between men has replaced foreign travel as the predominant mode of Shigella transmission in England. However, sexuality and HIV status are not routinely recorded for laboratory-reported Shigella, and the role of HIV in the Shigella epidemic is not well understood. ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2016-052962

    authors: Mohan K,Hibbert M,Rooney G,Canvin M,Childs T,Jenkins C,Simms I,Kirwan P,Delpech V,Yin Z,Hughes G,Field N

    更新日期:2018-02-01 00:00:00

  • Association of perceived partner non-monogamy with prevalent and incident sexual concurrency.

    abstract:OBJECTIVES:Concurrency is suggested as an important factor in sexually transmitted infection transmission and acquisition, though little is known regarding factors that may predict concurrency initiation. We examined the association between perception of a partner's non-monogamy (PPNM) and simultaneous or subsequent co...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052111

    authors: Sanchez DM,Schoenbach VJ,Harvey SM,Warren JT,Adimora AA,Poole C,Leone PA,Agnew CR

    更新日期:2016-06-01 00:00:00

  • Trends in gonorrhoea positivity by nucleic acid amplification test versus culture among Australian heterosexual men with a low prevalence of gonorrhoea, 2007-2014.

    abstract:BACKGROUND:Testing for gonorrhoea with nucleic acid amplification tests (NAATs) is not recommended in low-prevalence populations as it results in high numbers of false positive results. The aim of this study was to examine temporal trends of gonorrhoea positivity by NAAT and culture in heterosexual men in Victoria, Aus...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052246

    authors: Mannion PK,Fairley CK,Fehler G,Tabrizi SN,Tan WS,Chen MY,Bradshaw CS,Chow EP

    更新日期:2016-12-01 00:00:00

  • Human papillomavirus (HPV) infection in heterosexual South African men attending sexual health services: associations between HPV and HIV serostatus.

    abstract:OBJECTIVES:To investigate the distribution of human papillomavirus (HPV) genotypes and determine the associations between HPV infection and HIV coinfection in sexually active heterosexual men with anogenital warts (GW), male urethral discharge or asymptomatic men. METHODS:Valid specimens for HPV genotyping were obtain...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sti.2009.037598

    authors: Müller EE,Chirwa TF,Lewis DA

    更新日期:2010-06-01 00:00:00

  • Impact of HIV on adult (15-54) mortality in London: 1979-96.

    abstract:OBJECTIVE:To describe the impact of HIV on mortality in men and women aged 15-54 in London. DESIGN:Combination of routine mortality statistics with reports of AIDS deaths adjusted for underreporting and change in address from time of report to time of death. Calculation of standardised mortality ratios (SMRs) for male...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.75.6.385

    authors: Hickman M,Bardsley M,De Angelis D,Ward H

    更新日期:1999-12-01 00:00:00

  • Herpes simplex virus type 2 serological testing and psychosocial harm: a systematic review.

    abstract:BACKGROUND:Serological testing for herpes simplex virus (HSV) type 2 in persons without a history of genital herpes is not recommended, partly because of concerns that an HSV-2 diagnosis would lead to negative psychosocial sequelae. This review aimed to examine the evidence regarding the psychosocial effects of HSV-2 s...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sextrans-2011-050099

    authors: Ross K,Johnston C,Wald A

    更新日期:2011-12-01 00:00:00

  • In search of optimal genital herpes management and standard of care (INSIGHTS): doctors' and patients' perceptions of genital herpes.

    abstract:OBJECTIVE:To compare and contrast attitudes and behaviours of family doctors and patients with regard to genital herpes and its management. METHODS:Family doctors and infected patients were surveyed online to explore disease importance/seriousness, emotional impact, transmission and treatment. The study received ethic...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sti.2007.027631

    authors: Romanowski B,Zdanowicz YM,Owens ST

    更新日期:2008-02-01 00:00:00

  • Relative prevalence of different sexually transmitted infections in HIV-discordant sexual partnerships: data from a risk network study in a high-risk New York neighbourhood.

    abstract:OBJECTIVES:To determine infection patterns of sexually transmitted infections that facilitate HIV transmission among HIV-discordant couples. METHODS:112 initial respondents were recruited in an impoverished neighbourhood of Brooklyn, New York. Their sexual (and injection) partners were recruited in up to four addition...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2007.026815

    authors: Friedman SR,Bolyard M,Sandoval M,Mateu-Gelabert P,Maslow C,Zenilman J

    更新日期:2008-02-01 00:00:00

  • Emergent properties of HIV risk among injection drug users in Tallinn, Estonia: synthesis of individual and neighbourhood-level factors.

    abstract:OBJECTIVES:HIV/AIDS risk is embodied within multiple levels including structural and social levels. The aim of this study was to assess the effects of neighbourhood characteristics on HIV prevalence among injection drug users (IDU) residing in the area of Tallinn, Estonia in 2007. METHODS:A cross-sectional, multilevel...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2009.040212

    authors: Uusküla A,McMahon JM,Raag M,Silm S,Rüütel K,Talu A,Abel-Ollo K,Ahas R,Des Jarlais DC

    更新日期:2010-12-01 00:00:00

  • Is smoking tobacco an independent risk factor for HIV infection and progression to AIDS? A systemic review.

    abstract:OBJECTIVES:To systematically review the evidence of the relation between smoking tobacco and HIV seroconversion and progression to AIDS. METHODS:A systematic review was undertaken of studies to look at tobacco smoking as a risk factor for either HIV seroconversion or progression to AIDS. RESULTS:Six studies were iden...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,评审

    doi:10.1136/sti.2005.019505

    authors: Furber AS,Maheswaran R,Newell JN,Carroll C

    更新日期:2007-02-01 00:00:00

  • A pilot study of the feasibility of a vaginal washing cessation intervention among Kenyan female sex workers.

    abstract:BACKGROUND:Intravaginal practices including vaginal washing have been associated with HIV-1 acquisition. This association may be mediated by mucosal disruption, changes in vaginal flora or genital tract inflammatory responses. Reducing vaginal washing could lower women's risk of HIV-1 acquisition. METHODS:23 HIV-1 ser...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2012-050564

    authors: Masese L,McClelland RS,Gitau R,Wanje G,Shafi J,Kashonga F,Ndinya-Achola JO,Lester R,Richardson BA,Kurth A

    更新日期:2013-05-01 00:00:00

  • Reinfection by untreated partners of people treated for Chlamydia trachomatis and Neisseria gonorrhoeae: mathematical modelling study.

    abstract:OBJECTIVES:Reinfection after treatment for Chlamydia trachomatis or Neisseria gonorrhoeae reduces the effect of control interventions. We explored the impact of delays in treatment of current partners on the expected probability of reinfection of index cases using a mathematical model. METHODS:We used previously repor...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2013-051279

    authors: Low N,Heijne JC,Herzog SA,Althaus CL

    更新日期:2014-05-01 00:00:00

  • Prevalence of Chlamydia trachomatis: results from the first national population-based survey in France.

    abstract:BACKGROUND:Few studies have estimated Chlamydia trachomatis (CT) prevalence in the general population, most prevalence studies being based on people already attending healthcare settings. OBJECTIVES:To estimate the prevalence of CT in France, assess the feasibility of home sampling without any face-to-face interventio...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章,多中心研究

    doi:10.1136/sti.2009.038752

    authors: Goulet V,de Barbeyrac B,Raherison S,Prudhomme M,Semaille C,Warszawski J,CSF group.

    更新日期:2010-08-01 00:00:00

  • Identification of chlamydia and gonorrhoea among women in rural Haiti: maximising access to treatment in a resource poor setting.

    abstract:OBJECTIVE:To develop a risk assessment algorithm that will increase the identification and treatment of women with cervical infection in rural Haiti. METHODS:Study participants were randomly selected from new patients who accessed services at a women's health clinic in rural Haiti between June 1999 and December 2002. ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2005.016733

    authors: Smith Fawzi MC,Lambert W,Singler J,Léandre F,Nevil P,Bertrand D,Claude MS,Bertrand J,Louissaint M,Jeannis L,Ferrer JG,Cook EF,Salazar JJ,Farmer P,Mukherjee JS

    更新日期:2006-04-01 00:00:00

  • Mycoplasma genitalium is not associated with adverse outcomes of pregnancy in Guinea-Bissau.

    abstract:OBJECTIVE:To evaluate the impact of Mycoplasma genitalium on the outcome of pregnancy. METHODS:Cervical samples from women who had previously participated in a case-control study (designed to assess the impact of syphilis and HIV-2 on the outcome of pregnancy in Guinea-Bissau) were processed using a PCR assay to detec...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.78.4.289

    authors: Labbé AC,Frost E,Deslandes S,Mendonça AP,Alves AC,Pépin J

    更新日期:2002-08-01 00:00:00

  • Oral examination: a screening tool for HIV infection?

    abstract:OBJECTIVE:To estimate the predictive values for HIV infection of diagnosis of oral manifestations of the infection. METHOD:Prevalence of oral manifestations was compared in cross sectional blinded clinical examinations of homosexual men attending a genitourinary medicine clinic. Data were extrapolated to populations i...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.74.5.345

    authors: Robinson PG,Challacombe SJ,Sheiham A

    更新日期:1998-10-01 00:00:00

  • Dynamics of non-cohabiting sex partnering in sub-Saharan Africa: a modelling study with implications for HIV transmission.

    abstract:OBJECTIVE:To develop an analytical understanding of non-cohabiting sex partnering in sub-Saharan Africa (SSA) using nationally representative sexual behaviour data. METHOD:A non-homogenous Poisson stochastic process model was used to describe the dynamics of non-cohabiting sex. The model was applied to 25 countries in...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2014-051925

    authors: Omori R,Chemaitelly H,Abu-Raddad LJ

    更新日期:2015-09-01 00:00:00

  • Social determinants of community-level human papillomavirus vaccination coverage in aschool-based vaccination programme.

    abstract:OBJECTIVE:To assess social patterns in human papillomavirus (HPV) vaccine coverage in a school-based, government-funded vaccination programme located within a single-payer universal healthcare system. DESIGN:We conducted a cross-sectional analysis of HPV vaccine uptake data for the 2013-2014 school year for 131 local ...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2017-053357

    authors: Jean S 3rd,Elshafei M,Buttenheim A

    更新日期:2018-06-01 00:00:00

  • Evaluation of syndromic patient management algorithm for urethral discharge.

    abstract:OBJECTIVE:To determine feasibility, validity, and cost effectiveness of the syndromic approach to male patients with urethral discharge in Bandung, Indonesia. METHODS:The WHO algorithm on urethral discharge with no microscopy available was evaluated. Patients presented with a complaint of urethral discharge and if dis...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:

    authors: Djajakusumah T,Sudigdoadi S,Keersmaekers K,Meheus A

    更新日期:1998-06-01 00:00:00

  • Levels of anxiety and distress following receipt of positive screening tests in Australia's HPV-based cervical screening programme: a cross-sectional survey.

    abstract:OBJECTIVE:From December 2017, the Australian National Cervical Screening Program commenced 5 yearly primary human papillomavirus (HPV) screening; one of the first high-income countries to implement primary HPV screening. This study aimed to examine the psychosocial impact of self-reporting testing HPV positive in a sam...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2019-054290

    authors: Dodd RH,Mac O,Brotherton JML,Cvejic E,McCaffery KJ

    更新日期:2020-05-01 00:00:00

  • Chlamydia infection in individuals reporting contact with sexual partners with chlamydia: a cross-sectional study of sexual health clinic attendees.

    abstract:OBJECTIVES:We aimed to ascertain the proportion of positive, and predictive factors of chlamydia infection among females, heterosexual males and men who have sex with men (MSM) presenting to a sexual health service reporting contact with a chlamydia infected sexual partner. METHODS:A cross-sectional analysis of patien...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2015-052068

    authors: Huffam S,Chow EP,Fairley CK,Hocking J,Peel J,Chen M

    更新日期:2015-09-01 00:00:00

  • The effects of scale on the costs of targeted HIV prevention interventions among female and male sex workers, men who have sex with men and transgenders in India.

    abstract:BACKGROUND:The India AIDS Initiative (Avahan) project is involved in rapid scale-up of HIV-prevention interventions in high-risk populations. This study examines the cost variation of 107 non-governmental organisations (NGOs) implementing targeted interventions, over the start up (defined as period from project incepti...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2009.038547

    authors: Chandrashekar S,Guinness L,Kumaranayake L,Reddy B,Govindraj Y,Vickerman P,Alary M

    更新日期:2010-02-01 00:00:00

  • High-risk sexual behaviours among gay and bisexual men: comparing event-level casual sex encounters among seroconverters and non-seroconverters.

    abstract:BACKGROUND:With increasing use of non-condom-based HIV risk reduction strategies by gay and bisexual men (GBM), we compared occasions of condomless anal intercourse with casual partners (CLAIC) that resulted in HIV transmission and similar occasions when HIV transmission did not occur. METHODS:We compared two demograp...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2016-052749

    authors: Down I,Ellard J,Triffitt K,Zablotska I,Hurley M,Brown G,Bradley J,Prestage G

    更新日期:2017-08-01 00:00:00

  • Contribution of sexual practices (other than anal sex) to bacterial sexually transmitted infection transmission in men who have sex with men: a cross-sectional analysis using electronic health records.

    abstract:OBJECTIVE:We quantified the proportion of cases and risk of primary syphilis (PS), urethral chlamydia (UCT) and urethral gonorrhoea (UGC) attributable to sexual practices other than anal sex. METHODS:In this cross-sectional study, electronic records for men who have sex with men (MSM) who attended the Melbourne Sexual...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2013-051103

    authors: Nash JL,Hocking JS,Read TR,Chen MY,Bradshaw CS,Forcey DS,Fairley CK

    更新日期:2014-02-01 00:00:00

  • "A bit more truthful": the validity of adolescent sexual behaviour data collected in rural northern Tanzania using five methods.

    abstract:OBJECTIVE:To assess the validity of sexual behaviour data collected from African adolescents using five methods. METHODS:9280 Tanzanian adolescents participated in a biological marker and face to face questionnaire survey and 6079 in an assisted self-completion questionnaire survey; 74 participated in in-depth intervi...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2004.011924

    authors: Plummer ML,Ross DA,Wight D,Changalucha J,Mshana G,Wamoyi J,Todd J,Anemona A,Mosha FF,Obasi AI,Hayes RJ

    更新日期:2004-12-01 00:00:00

  • Acute hepatitis A infection after hepatitis A immunity in a HIV-positive individual.

    abstract::Hepatitis A is a self-limiting infection caused by the hepatitis A virus (HAV), transmitted predominantly by the faecal-oral route including some sexual practices. Outbreaks are commonly reported in the men who have sex with men (population. Previous exposure is thought to provide life-long immunity against subsequent...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2017-053246

    authors: Lee MJ,Douthwaite S,Kulasegaram R

    更新日期:2018-02-01 00:00:00

  • Lack of evidence for the involvement of rectal and oral trichomonads in the aetiology of vaginal trichomoniasis in Ghana.

    abstract:OBJECTIVE:To investigate the possible involvement of human trichomonads (Pentatrichomonas hominis and Trichomonas tenax) other than Trichomonas vaginalis in the aetiology of vaginal trichomoniasis. METHODS:Vaginal swabs taken from women attending antenatal clinics were tested for Trichomonas vaginalis by traditional a...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2006.020941

    authors: Adu-Sarkodie Y,Opoku BK,Crucitti T,Weiss HA,Mabey D

    更新日期:2007-04-01 00:00:00

  • Increasing the perceived relevance of cervical screening in older women who do not plan to attend screening.

    abstract:OBJECTIVES:Uptake of cervical screening among women aged 50-64 years is declining. Not feeling at risk because of current sexual behaviour is a reason some older women give for not being screened. We hypothesised that explaining the long interval between acquiring human papillomavirus (HPV) and developing cervical canc...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2019-054120

    authors: Marlow LAV,Ryan M,Waller J

    更新日期:2020-02-01 00:00:00

  • The Spectrum projection package: improvements in estimating incidence by age and sex, mother-to-child transmission, HIV progression in children and double orphans.

    abstract:BACKGROUND:The Spectrum program is used to estimate key HIV indicators from the trends in incidence and prevalence estimated by the Estimation and Projection Package or the Workbook. These indicators include the number of people living with HIV, new infections, AIDS deaths, AIDS orphans, the number of adults and childr...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sti.2010.044222

    authors: Stover J,Johnson P,Hallett T,Marston M,Becquet R,Timaeus IM

    更新日期:2010-12-01 00:00:00

  • A comparison of respondent-driven and venue-based sampling of female sex workers in Liuzhou, China.

    abstract:OBJECTIVES:To compare two methods for sampling female sex workers (FSWs) for bio-behavioural surveillance. We compared the populations of sex workers recruited by the venue-based Priorities for Local AIDS Control Efforts (PLACE) method and a concurrently implemented network-based sampling method, respondent-driven samp...

    journal_title:Sexually transmitted infections

    pub_type: 杂志文章

    doi:10.1136/sextrans-2012-050638

    authors: Weir SS,Merli MG,Li J,Gandhi AD,Neely WW,Edwards JK,Suchindran CM,Henderson GE,Chen XS

    更新日期:2012-12-01 00:00:00