New insights into the mechanism of inhibition of p53 by simian virus 40 large T antigen.

abstract：:We have undertaken total synthesis of the Saccharomyces cerevisiae a-factor (NH2-YIIKGVFWDPAC[S-farnesyl]-COOCH3) and several Cys-12 analogs to determine the significance of S-farnesylation and carboxy-terminal methyl esterification to the biological activity of this lipopeptide mating pheromone. Replacement of either...

journal_title：Molecular and cellular biology

authors： Marcus S,Caldwell GA,Miller D,Xue CB,Naider F,Becker JM

更新日期：1991-07-01 00:00:00

abstract：:RNA editing of specific residues by adenosine deamination is a nuclear process catalyzed by adenosine deaminases acting on RNA (ADAR). Different promoters in the ADAR1 gene give rise to two forms of the protein: a constitutive promoter expresses a transcript encoding (c)ADAR1, and an interferon-induced promoter expres...

journal_title：Molecular and cellular biology

authors： Poulsen H,Nilsson J,Damgaard CK,Egebjerg J,Kjems J

更新日期：2001-11-01 00:00:00

abstract：:An RNA editing mechanism modifies apolipoprotein B (apo-B) mRNA in the intestine by converting cytosine at nucleotide (nt) 6666 to uracil. To define the sequence requirements for editing, mutant apo-B RNAs were analyzed for the ability to be edited in vitro by enterocyte extracts. Editing was detected by a sensitive a...

journal_title：Molecular and cellular biology

authors： Driscoll DM,Lakhe-Reddy S,Oleksa LM,Martinez D

更新日期：1993-12-01 00:00:00

abstract：:The fibroblast growth factor (FGF) family consists of seven members whose activities are thought to be mediated by multiple receptors. Here we describe the cDNA cloning, expression, and characterization of a cysteine-rich FGF receptor (CFR) that is distinct from previously identified FGF receptors. The deduced amino a...

journal_title：Molecular and cellular biology

authors： Burrus LW,Zuber ME,Lueddecke BA,Olwin BB

更新日期：1992-12-01 00:00:00

abstract：:Posttranslational modification of general transcription factors may be an important mechanism for global gene regulation. The general transcription factor IIA (TFIIA) binds to the TATA binding protein (TBP) and is essential for high-level transcription mediated by various activators. Modulation of the TFIIA-TBP intera...

journal_title：Molecular and cellular biology

authors： Solow SP,Lezina L,Lieberman PM

更新日期：1999-04-01 00:00:00

abstract：:Regulatory regions of the mouse muscle creatine kinase (MCK) gene, previously discovered by analysis in cultured muscle cells, were analyzed in transgenic mice. The 206-bp MCK enhancer at nt-1256 was required for high-level expression of MCK-chloramphenicol acetyltransferase fusion genes in skeletal and cardiac muscle...

journal_title：Molecular and cellular biology

authors： Donoviel DB,Shield MA,Buskin JN,Haugen HS,Clegg CH,Hauschka SD

更新日期：1996-04-01 00:00:00

abstract：:Metazoan replication-dependent histone mRNAs are the only eukaryotic mRNAs that are not polyadenylated. The cleavage of histone pre-mRNA to form the unique 3' end requires the U7 snRNP and the stem-loop binding protein (SLBP) that binds the 3' end of histone mRNA. U7 snRNP contains three novel proteins, Lsm10 and Lsm1...

journal_title：Molecular and cellular biology

authors： Wagner EJ,Marzluff WF

更新日期：2006-09-01 00:00:00

abstract：:Much of the regulatory diversity in eukaryotic transcription is provided by coregulators, which are recruited by DNA-binding factors to propagate signaling to basal machinery or chromatin. p160 family members, including the glucocorticoid receptor (GR)-interacting protein 1 (GRIP1), function as coactivators for GR, a ...

journal_title：Molecular and cellular biology

authors： Dobrovolna J,Chinenov Y,Kennedy MA,Liu B,Rogatsky I

更新日期：2012-02-01 00:00:00

abstract：:Thrombin stimulation of platelets induces a transient increase in the specific activity of pp60c-src followed by a redistribution of pp60c-src to the Triton X-100-insoluble, cytoskeleton-rich fraction. Concomitant with the observed increase in pp60c-src activity was a rapid dephosphorylation of tyrosine 527 in 10 to 1...

journal_title：Molecular and cellular biology

authors： Clark EA,Brugge JS

更新日期：1993-03-01 00:00:00

abstract：:Cancer cells may evade immune surveillance as a result of defective antigen processing and presentation. In this study, we demonstrate that CD40 ligation overcomes this defect through the coordinated action of the transcription factors NF-kappaB and interferon regulatory factor 1 (IRF-1). We show that unlike interfero...

journal_title：Molecular and cellular biology

authors： Moschonas A,Kouraki M,Knox PG,Thymiakou E,Kardassis D,Eliopoulos AG

更新日期：2008-10-01 00:00:00

abstract：:Understanding the mechanisms that drive the differentiation of dopaminergic (DA) neurons is crucial for successful development of novel therapies for Parkinson's disease, in which DA neurons progressively degenerate. However, the mechanisms underlying the differentiation-promoting effects of Wnt5a on DA precursors are...

journal_title：Molecular and cellular biology

authors： Čajánek L,Ganji RS,Henriques-Oliveira C,Theofilopoulos S,Koník P,Bryja V,Arenas E

更新日期：2013-01-01 00:00:00

abstract：:The protein components that direct and activate accurate transcription by rat RNA polymerase I were studied in extracts of Novikoff hepatoma ascites cells. A minimum of at least two components, besides RNA polymerase I, that are necessary for efficient utilization of templates were identified. The first factor, rat SL...

journal_title：Molecular and cellular biology

authors： Smith SD,Oriahi E,Lowe D,Yang-Yen HF,O'Mahony D,Rose K,Chen K,Rothblum LI

更新日期：1990-06-01 00:00:00

abstract：:Immunoglobulin (Ig) mu heavy-chain gene enhancer activity is mediated by multiple DNA binding proteins. Mutations of several protein binding sites in the enhancer do not affect enhancer activity significantly. This feature, termed redundancy, is thought to be due to functional compensation of the mutated sites by othe...

journal_title：Molecular and cellular biology

authors： Dang W,Nikolajczyk BS,Sen R

更新日期：1998-11-01 00:00:00

abstract：:Mediator is a general coactivator complex connecting transcription activators and RNA polymerase II. Recent work has shown that the nuclear receptor-interacting MED1/TRAP220 subunit of Mediator is required for peroxisome proliferator-activated receptor gamma (PPARgamma)-stimulated adipogenesis of mouse embryonic fibro...

journal_title：Molecular and cellular biology

authors： Ge K,Cho YW,Guo H,Hong TB,Guermah M,Ito M,Yu H,Kalkum M,Roeder RG

更新日期：2008-02-01 00:00:00

abstract：:Mutations in mitochondrial DNA (mtDNA) cause a variety of relatively rare human diseases and may contribute to the pathogenesis of other, more common degenerative diseases. This stimulates interest in the capacity of mitochondria to repair damage to mtDNA. Several recent studies have shown that some types of damage to...

journal_title：Molecular and cellular biology

authors： Pinz KG,Bogenhagen DF

更新日期：1998-03-01 00:00:00

abstract：:Activation of multiple signaling pathways is required to trigger the full spectrum of in vitro and in vivo phenotypic traits associated with neoplastic transformation by oncogenic Ras. To determine which of these pathways are important for N-ras tumorigenesis in human cancer cells and also to investigate the possibili...

journal_title：Molecular and cellular biology

authors： Gupta S,Plattner R,Der CJ,Stanbridge EJ

更新日期：2000-12-01 00:00:00

abstract：:Signal transducers and activators of transcription (STATs) are transcription factors that mediate normal biologic responses to cytokines and growth factors. However, abnormal activation of certain STAT family members, including Stat3, is increasingly associated with oncogenesis. In fibroblasts expressing the Src oncop...

journal_title：Molecular and cellular biology

authors： Turkson J,Bowman T,Adnane J,Zhang Y,Djeu JY,Sekharam M,Frank DA,Holzman LB,Wu J,Sebti S,Jove R

更新日期：1999-11-01 00:00:00

abstract：:The rRNA genes in most eucaryotic organisms are present in a tandem array. There is substantial evidence that transcription of one of these genes may not be independent of transcription of others. In particular, in the yeast Saccharomyces cerevisiae, the enhancer of rRNA transcription that lies 2.2 kilobases 5' of the...

journal_title：Molecular and cellular biology

authors： Johnson SP,Warner JR

更新日期：1989-11-01 00:00:00

abstract：:Dexamethasone increases type 1 plasminogen activator inhibitor (PAI-1) activity released from the human fibrosarcoma cell line HT-1080. We demonstrated that dexamethasone caused about 10-fold increases in the intracellular and extracellular levels of PAI-1 protein, as measured by an enzyme-linked immunosorbent assay, ...

journal_title：Molecular and cellular biology

authors： Andreasen PA,Pyke C,Riccio A,Kristensen P,Nielsen LS,Lund LR,Blasi F,Danø K

更新日期：1987-08-01 00:00:00

abstract：:The histone H1(0)-encoding gene is expressed in vertebrates in differentiating cells during the arrest of proliferation. In the H1(0) promoter, a specific regulatory element, which we named the H4 box, exhibits features which implicate a role in mediating H1(0) gene expression in response to both differentiation and c...

journal_title：Molecular and cellular biology

authors： Lemercier C,Duncliffe K,Boibessot I,Zhang H,Verdel A,Angelov D,Khochbin S

更新日期：2000-09-01 00:00:00

abstract：:Smad proteins play a key role in the intracellular signaling of the transforming growth factor beta (TGF-beta) superfamily of extracellular polypeptides that initiate signaling from the cell surface through serine/threonine kinase receptors. A subclass of Smad proteins, including Smad6 and Smad7, has been shown to fun...

journal_title：Molecular and cellular biology

authors： Datta PK,Moses HL

更新日期：2000-05-01 00:00:00

abstract：:In Saccharomyces cerevisiae, the heterodimeric transcription factor SBF (for SCB binding factor) is composed of Swi4 and Swi6 and activates gene expression at the G(1)/S-phase transition of the mitotic cell cycle. Cell cycle commitment is associated not only with major alterations in gene expression but also with high...

journal_title：Molecular and cellular biology

authors： Baetz K,Moffat J,Haynes J,Chang M,Andrews B

更新日期：2001-10-01 00:00:00

abstract：:P bodies are cytoplasmic RNA granules containing the Dcp1-Dcp2 decapping enzymes where mRNA decay can occur. Here, we describe the characterization of P bodies in the fission yeast Schizosaccharomyces pombe. Most information on the property and function of P bodies stems from studies in the distantly related budding y...

journal_title：Molecular and cellular biology

authors： Wang CY,Chen WL,Wang SW

更新日期：2013-03-01 00:00:00

abstract：:Liver regeneration is a rapid and concerted response to injury, in which growth factor-generated intracellular signals result in activation of transcription factors, DNA synthesis, and hepatocyte proliferation. However, the link between cytoplasmic signals resulting in proliferative response to liver injury remains to...

journal_title：Molecular and cellular biology

authors： Bard-Chapeau EA,Yuan J,Droin N,Long S,Zhang EE,Nguyen TV,Feng GS

更新日期：2006-06-01 00:00:00

abstract：:A unique genetic selection was devised at the HIS4 locus to address the mechanism of translation initiation in Saccharomyces cerevisiae and to probe sequence requirements at the normal translational initiator region that might participate in ribosomal recognition of the AUG start codon. The first AUG codon at the 5' e...

journal_title：Molecular and cellular biology

authors： Donahue TF,Cigan AM

更新日期：1988-07-01 00:00:00

abstract：:Adipocytes constitute a major part of the bone marrow stroma in vivo and may play an active role in lymphohematopoiesis. Earlier studies had shown that the bone marrow stromal cell clone BMS2 was capable of adipocyte differentiation in vitro, in addition to its well-defined ability to support B lymphopoiesis. We now d...

journal_title：Molecular and cellular biology

authors： Gimble JM,Dorheim MA,Cheng Q,Pekala P,Enerback S,Ellingsworth L,Kincade PW,Wang CS

更新日期：1989-11-01 00:00:00

abstract：:The yeast Mcm1 protein is a member of the MADS box family of transcriptional regulatory factors, a class of DNA-binding proteins that control numerous cellular and developmental processes in yeast, Drosophila melanogaster, plants, and mammals. Although these proteins bind DNA on their own, they often combine with diff...

journal_title：Molecular and cellular biology

authors： Mead J,Bruning AR,Gill MK,Steiner AM,Acton TB,Vershon AK

更新日期：2002-07-01 00:00:00

abstract：:In Blastocladiella emersonii zoospores, a set of proteins was found associated with the ribosomes and free ribonucleoprotein particles distinct from the ribosomes and polyribosomes. These proteins were designated P120, P105, P64, P56, and P42 based on their molecular weights determined by gel electrophoresis. Synthesi...

journal_title：Molecular and cellular biology

authors： Jaworski AJ,Stumhofer P

更新日期：1981-04-01 00:00:00

abstract：:The binding of the U1 small nuclear ribonucleoprotein (snRNP)-specific proteins C, A, and 70K to U1 small nuclear RNA (snRNA) was analyzed. Assembly of U1 snRNAs from bean and soybean and a set of mutant Xenopus U1 snRNAs into U1 snRNPs in Xenopus egg extracts was studied. The ability to bind proteins was analyzed by ...

journal_title：Molecular and cellular biology

authors： Hamm J,van Santen VL,Spritz RA,Mattaj IW

更新日期：1988-11-01 00:00:00

abstract：:The cell cycle-regulatory transcription factor E2F-1 is regulated by interactions with proteins such as the retinoblastoma gene product and by cell cycle-dependent alterations in E2F-1 mRNA abundance. To better understand this latter phenomenon, we have isolated the human E2F-1 promoter. The human E2F-1 promoter, fuse...

journal_title：Molecular and cellular biology

authors： Neuman E,Flemington EK,Sellers WR,Kaelin WG Jr

更新日期：1994-10-01 00:00:00