Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons.

abstract：:G proteins are molecular switches that control a wide variety of physiological functions, including neurotransmission, transcriptional activation, cell migration, cell growth. and proliferation. The ability of GTPases to participate in signaling events is determined by the ratio of GTP-bound to GDP-bound forms in the ...

journal_title：Molecular and cellular biology

authors： Xia C,Ma W,Stafford LJ,Liu C,Gong L,Martin JF,Liu M

更新日期：2003-04-01 00:00:00

abstract：:Regulation of variant surface glycoprotein (VSG) mRNA turnover in Trypanosoma brucei was studied in bloodstream forms, in procyclic cells, and during in vitro transformation of bloodstream forms to procyclic cells by approach-to-equilibrium labeling and pulse-chase experiments. Upon initiation of transformation at 27 ...

journal_title：Molecular and cellular biology

authors： Ehlers B,Czichos J,Overath P

更新日期：1987-03-01 00:00:00

abstract：:The forkhead transcription factor FoxM1 has been reported to regulate, variously, proliferation and/or spindle formation during the G2/M transition of the cell cycle. Here we define specific functions of FoxM1 during brain development by the investigation of FoxM1 loss-of-function mutations in the context of Sonic hed...

journal_title：Molecular and cellular biology

authors： Schüller U,Zhao Q,Godinho SA,Heine VM,Medema RH,Pellman D,Rowitch DH

更新日期：2007-12-01 00:00:00

abstract：:Posttranslational modification of general transcription factors may be an important mechanism for global gene regulation. The general transcription factor IIA (TFIIA) binds to the TATA binding protein (TBP) and is essential for high-level transcription mediated by various activators. Modulation of the TFIIA-TBP intera...

journal_title：Molecular and cellular biology

authors： Solow SP,Lezina L,Lieberman PM

更新日期：1999-04-01 00:00:00

abstract：:We describe an interaction between homeodomain-interacting protein kinase 1 (HIPK1) and Daxx, two transcriptional regulators important in transducing growth-regulatory signals. We demonstrate that HIPK1 is ubiquitously expressed in mice and humans and localizes predominantly to the nucleus. Daxx normally resides withi...

journal_title：Molecular and cellular biology

authors： Ecsedy JA,Michaelson JS,Leder P

更新日期：2003-02-01 00:00:00

abstract：:Efficient cleavage of both forms of eukaryotic initiation factor 4G (eIF4G-1 and eIF4G-2) has been achieved in HeLa cells by incubation with hybrid proteins containing poliovirus 2Apro. Entry of these proteins into cells is promoted by adenovirus particles. Substantial levels of ongoing translation on preexisting cell...

journal_title：Molecular and cellular biology

authors： Novoa I,Carrasco L

更新日期：1999-04-01 00:00:00

abstract：:Two Saccharomyces cerevisiae genes isolated in a differential hybridization screening for DNA damage regulation (DDR genes) were also transcriptionally regulated by heat shock treatment. A 0.45-kilobase transcript homologous to the DDRA2 gene and a 1.25-kilobase transcript homologous to the DDR48 gene accumulated afte...

journal_title：Molecular and cellular biology

authors： McClanahan T,McEntee K

更新日期：1986-01-01 00:00:00

abstract：:RBM25 has been shown to associate with splicing cofactors SRm160/300 and assembled splicing complexes, but little is known about its splicing regulation. Here, we characterize the functional role of RBM25 in alternative pre-mRNA splicing. Increased RBM25 expression correlated with increased apoptosis and specifically ...

journal_title：Molecular and cellular biology

authors： Zhou A,Ou AC,Cho A,Benz EJ Jr,Huang SC

更新日期：2008-10-01 00:00:00

abstract：:High-dose estrogen administration induces anemia in mammals. In chickens, estrogens stimulate outgrowth of bone marrow-derived erythroid progenitor cells and delay their maturation. This delay is associated with down-regulation of many erythroid cell-specific genes, including alpha- and beta-globin, band 3, band 4.1, ...

journal_title：Molecular and cellular biology

authors： Blobel GA,Sieff CA,Orkin SH

更新日期：1995-06-01 00:00:00

abstract：:Cwc25 has previously been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (nineteen complex, or NTC) involved in spliceosome activation. We show here that Cwc25 is neither tightly associated with NTC nor required for spliceosome activation but is required f...

journal_title：Molecular and cellular biology

authors： Chiu YF,Liu YC,Chiang TW,Yeh TC,Tseng CK,Wu NY,Cheng SC

更新日期：2009-11-01 00:00:00

abstract：:c-sis/platelet-derived growth factor 2 (PDGF-2) is a prototype growth factor with transforming potential. The c-sis/PDGF-2 transcript contains a long 5' untranslated sequence (UTS) that is highly G.C rich. To examine the influence of this sequence on sis/PDGF-2 expression, we localized the c-sis/PDGF-2 promoter and us...

journal_title：Molecular and cellular biology

authors： Rao CD,Pech M,Robbins KC,Aaronson SA

更新日期：1988-01-01 00:00:00

abstract：:We analyzed epsilon-globin transcription in erythroid cells and in erythroid extracts to determine the requirements for enhancer-dependent expression of this gene. Mutations that abolished GATA-1 binding at a single position in the promoter prevented interaction with enhancers, whereas elimination of a second more dis...

journal_title：Molecular and cellular biology

authors： Gong Q,Dean A

更新日期：1993-02-01 00:00:00

abstract：:The Drosophila gap gene knirps (kni) is required for abdominal segmentation. It encodes a steroid/thyroid orphan receptor-type transcription factor which is distributed in a broad band of nuclei in the posterior region of the blastoderm. To identify essential domains of the kni protein (KNI), we cloned and sequenced t...

journal_title：Molecular and cellular biology

authors： Gerwin N,La Rosée A,Sauer F,Halbritter HP,Neumann M,Jäckle H,Nauber U

更新日期：1994-12-01 00:00:00

abstract：:Posttranscriptional and posttranslational modification of macromolecules is known to fine-tune their functions. Trm112 is unique, acting as an activator of both tRNA and protein methyltransferases. Here we report that in Saccharomyces cerevisiae, Trm112 is required for efficient ribosome synthesis and progression thro...

journal_title：Molecular and cellular biology

authors： Figaro S,Wacheul L,Schillewaert S,Graille M,Huvelle E,Mongeard R,Zorbas C,Lafontaine DL,Heurgué-Hamard V

更新日期：2012-06-01 00:00:00

abstract：:The actin cytoskeleton is a fundamental component of eukaryotic cells, with both structural and motile roles. Actin and many of the actin-binding proteins found in different cell types are highly conserved, showing considerable similarity in both primary structure and biochemical properties. To make detailed compariso...

journal_title：Molecular and cellular biology

authors： Adams AE,Shen W,Lin CS,Leavitt J,Matsudaira P

更新日期：1995-01-01 00:00:00

abstract：:The Sry-related high-mobility-group box transcription factor Sox9 recruits the redundant L-Sox5 and Sox6 proteins to effect chondrogenesis, but the mode of action of the trio remains unclear. We identify here a highly conserved 359-bp sequence 10 kb upstream of the Agc1 gene for aggrecan, a most essential cartilage pr...

journal_title：Molecular and cellular biology

authors： Han Y,Lefebvre V

更新日期：2008-08-01 00:00:00

abstract：:We have isolated a yeast conditional mutant which rapidly ceases synthesis of mRNA when subjected to the nonpermissive temperature. This mutant (rpb1-1) was constructed by replacing the wild-type chromosomal copy of the gene encoding the largest subunit of RNA polymerase II with one mutagenized in vitro. The rapid ces...

journal_title：Molecular and cellular biology

authors： Nonet M,Scafe C,Sexton J,Young R

更新日期：1987-05-01 00:00:00

abstract：:Previous studies demonstrated that growth in DBA/2 mice of MDW4, a wheat germ agglutinin-resistant (WGAr) mutant of the highly metastatic MDAY-D2 DBA/2 mouse tumor, led to the emergence of WGA-sensitive (WGAs) revertants having higher ploidy levels at the site of inoculation as well as at distant visceral metastases. ...

journal_title：Molecular and cellular biology

authors： Kerbel RS,Lagarde AE,Dennis JW,Donaghue TP

更新日期：1983-04-01 00:00:00

abstract：:Bone morphogenetic protein 7 (BMP7) stimulates renal branching morphogenesis via p38 mitogen-activated protein kinase (p38(MAPK)) and activating transcription factor 2 (ATF-2) (M. C. Hu, D. Wasserman, S. Hartwig, and N. D. Rosenblum, J. Biol. Chem. 279:12051-12059, 2004). Here, we demonstrate a novel role for integrin...

journal_title：Molecular and cellular biology

authors： Leung-Hagesteijn C,Hu MC,Mahendra AS,Hartwig S,Klamut HJ,Rosenblum ND,Hannigan GE

更新日期：2005-05-01 00:00:00

abstract：:Several factors that mediate activation by nuclear receptors also modify the chemical and structural composition of chromatin. Prominent in this diverse group is the steroid receptor coactivator 1 (SRC-1) family, which interact with agonist-bound nuclear receptors, thereby coupling them to multifunctional transcriptio...

journal_title：Molecular and cellular biology

authors： DiRenzo J,Shang Y,Phelan M,Sif S,Myers M,Kingston R,Brown M

更新日期：2000-10-01 00:00:00

abstract：:The rRNA genes in most eucaryotic organisms are present in a tandem array. There is substantial evidence that transcription of one of these genes may not be independent of transcription of others. In particular, in the yeast Saccharomyces cerevisiae, the enhancer of rRNA transcription that lies 2.2 kilobases 5' of the...

journal_title：Molecular and cellular biology

authors： Johnson SP,Warner JR

更新日期：1989-11-01 00:00:00

abstract：:The human Ki-ras gene was previously reported to contain two alternative fourth exons which encode two distinct p21 proteins differing only at their carboxy termini. The present study shows that either p21 protein is able on its own to transform NIH 3T3 cells to a tumorigenic state. ...

journal_title：Molecular and cellular biology

authors： McCoy MS,Weinberg RA

更新日期：1986-04-01 00:00:00

abstract：:In Saccharomyces cerevisiae, a phosphorelay signal transduction pathway composed of Sln1p, Ypd1p, and Ssk1p, which are homologous to bacterial two-component signal transducers, is involved in the osmosensing mechanism. In response to high osmolarity, the phosphorelay system is inactivated and Ssk1p remains unphosphory...

journal_title：Molecular and cellular biology

authors： Sato N,Kawahara H,Toh-e A,Maeda T

更新日期：2003-09-01 00:00:00

abstract：:Intracisternal A-particle (IAP) expression in mouse cells has been correlated with hypomethylation of HhaI and HpaII sites in proviral long terminal repeats (LTRs). In a previous study, in vitro methylation of three HhaI sites in the U3 region of the LTR from the cloned genomic IAP element, MIA14, was shown to inhibit...

journal_title：Molecular and cellular biology

authors： Falzon M,Kuff EL

更新日期：1991-01-01 00:00:00

abstract：:The nucleotide sequence of 5'-noncoding and N-terminal coding regions of two coordinately regulated, repressible acid phosphatase genes from Saccharomyces cerevisiae were determined. These unlinked genes encode different, but structurally related polypeptides of molecular weights 60,000 and 56,000. The DNA sequences o...

journal_title：Molecular and cellular biology

authors： Thill GP,Kramer RA,Turner KJ,Bostian KA

更新日期：1983-04-01 00:00:00

abstract：:The catalytic function of Src-related tyrosine protein kinases is repressed by phosphorylation of a conserved carboxy-terminal tyrosine residue. Recent studies suggest that this inhibitory event is not the result of autophosphorylation but that it is mediated by another cytoplasmic tyrosine protein kinase, termed p50c...

journal_title：Molecular and cellular biology

authors： Gervais FG,Chow LM,Lee JM,Branton PE,Veillette A

更新日期：1993-11-01 00:00:00

abstract：:The basis for nucleolar dominance in mouse-human cell hybrids which contained all of the mouse chromosomes but an incomplete set of human chromosomes (M greater than H) was examined at the molecular level. S1 mapping data showed that these cells had the expected levels of steady-state rRNA transcribed from mouse ribos...

journal_title：Molecular and cellular biology

authors： Miesfeld R,Sollner-Webb B,Croce C,Arnheim N

更新日期：1984-07-01 00:00:00

abstract：:Interleukin-5 (IL-5) is produced by T lymphocytes and known to support B-cell growth and eosinophilic differentiation of the progenitor cells. Using ATL-16T cells which express IL-5 mRNA, we have identified a region within the human IL-5 gene promoter that regulates IL-5 gene transcription. This cis-acting sequence co...

journal_title：Molecular and cellular biology

authors： Yamagata T,Nishida J,Sakai R,Tanaka T,Honda H,Hirano N,Mano H,Yazaki Y,Hirai H

更新日期：1995-07-01 00:00:00

abstract：:GPR103 is a G-protein-coupled receptor with reported expression in brain, heart, kidney, adrenal gland, retina, and testis. It encodes a 455-amino-acid protein homologous to neuropeptide FF2, neuropeptide Y2, and galanin GalR1 receptors. Its natural ligand was recently identified as 26RFa, a novel human RF-amide-relat...

journal_title：Molecular and cellular biology

authors： Baribault H,Danao J,Gupte J,Yang L,Sun B,Richards W,Tian H

更新日期：2006-01-01 00:00:00

abstract：:In eukaryotic cells, cohesion between sister chromatids allows chromosomes to biorient on the metaphase plate and holds them together until they separate into daughter cells during mitosis. Cohesion is mediated by the cohesin protein complex. Although the association of this complex with particular regions of the geno...

journal_title：Molecular and cellular biology

authors： Bausch C,Noone S,Henry JM,Gaudenz K,Sanderson B,Seidel C,Gerton JL

更新日期：2007-12-01 00:00:00