Significance of C-terminal cysteine modifications to the biological activity of the Saccharomyces cerevisiae a-factor mating pheromone.

abstract：:The intracellular signaling mechanisms underlying the pathogenesis of cardiac diseases are not fully understood. We report here that selective deletion of Shp2, an SH2-containing cytoplasmic tyrosine phosphatase, in striated muscle results in severe dilated cardiomyopathy in mice, leading to heart failure and prematur...

journal_title：Molecular and cellular biology

authors： Princen F,Bard E,Sheikh F,Zhang SS,Wang J,Zago WM,Wu D,Trelles RD,Bailly-Maitre B,Kahn CR,Chen Y,Reed JC,Tong GG,Mercola M,Chen J,Feng GS

更新日期：2009-01-01 00:00:00

abstract：:Sialic acid-binding immunoglobulin-like lectins (siglecs) are predominately expressed on immune cells. They are best known as regulators of cell signaling mediated by cytoplasmic tyrosine motifs and are increasingly recognized as receptors for pathogens that bear sialic acid-containing glycans. Most siglec proteins un...

journal_title：Molecular and cellular biology

authors： Tateno H,Li H,Schur MJ,Bovin N,Crocker PR,Wakarchuk WW,Paulson JC

更新日期：2007-08-01 00:00:00

abstract：:The c-abl protooncogene is unusual in two respects; it has multiple, widely space N-terminal coding exons transcribed by different promoters, and it is the target of the translocations that form the Philadelphia chromosome found in cells of chronic myelogenous leukemia patients. To understand the organization of the g...

journal_title：Molecular and cellular biology

authors： Bernards A,Rubin CM,Westbrook CA,Paskind M,Baltimore D

更新日期：1987-09-01 00:00:00

abstract：:To investigate the role of myogenin in regulating acetylcholine receptor expression in adult muscle, this muscle-specific basic helix-loop-helix transcription factor was overexpressed in transgenic mice by using regulatory elements conferring strong expression confined to differentiated postmitotic muscle fibers. Many...

journal_title：Molecular and cellular biology

authors： Gundersen K,Rabben I,Klocke BJ,Merlie JP

更新日期：1995-12-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) plays important roles in the regulation of proliferation, differentiation, apoptosis, and carcinogenesis. To identify genes responsible for maintaining the phenotype induced by TGF-beta, we performed a retrovirus-mediated gene trap screening designed to isolate TGF-beta-respo...

journal_title：Molecular and cellular biology

authors： Akiyama N,Matsuo Y,Sai H,Noda M,Kizaka-Kondoh S

更新日期：2000-05-01 00:00:00

abstract：:The treatment of cells with histone deacetylase inhibitors (HDACi) was reported to reveal the acetylation of STAT1 at lysine 410 and lysine 413 (O. H. Krämer et al., Genes Dev. 20:473-485, 2006). STAT1 acetylation was proposed to regulate apoptosis by facilitating binding to NF-κB and to control immune responses by su...

journal_title：Molecular and cellular biology

authors： Antunes F,Marg A,Vinkemeier U

更新日期：2011-07-01 00:00:00

abstract：:The MyoD gene can orchestrate the expression of the skeletal muscle differentiation program. We have identified the regions of the gene necessary to reproduce transcription specific to skeletal myoblasts and myotubes. A proximal regulatory region (PRR) contains a conserved TATA box, a CCAAT box, and a GC-rich region t...

journal_title：Molecular and cellular biology

authors： Tapscott SJ,Lassar AB,Weintraub H

更新日期：1992-11-01 00:00:00

abstract：:The Son of sevenless proteins (Sos) are guanine nucleotide exchange factors involved in the activation of Ras by cytoplasmic and receptor tyrosine kinases. Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites. Previous studies have demonstrated that growth factor-...

journal_title：Molecular and cellular biology

authors： Corbalan-Garcia S,Yang SS,Degenhardt KR,Bar-Sagi D

更新日期：1996-10-01 00:00:00

abstract：:The differentiation of dental epithelia into enamel-producing ameloblasts or the root epithelial lineage compartmentalizes teeth into crowns and roots. Bmp signaling has been linked to enamel formation, but its role in root epithelial lineage differentiation is unclear. Here we show that cessation of epithelial Bmp si...

journal_title：Molecular and cellular biology

authors： Yang Z,Hai B,Qin L,Ti X,Shangguan L,Zhao Y,Wiggins L,Liu Y,Feng JQ,Chang JY,Wang F,Liu F

更新日期：2013-12-01 00:00:00

abstract：:Individuals with the inherited cancer predisposition syndrome neurofibromatosis 2 (NF2) develop several central nervous system (CNS) malignancies, including glial cell neoplasms (ependymomas). Recent studies have suggested that the NF2 protein, merlin (or schwannomin), may regulate receptor tyrosine kinase signaling, ...

journal_title：Molecular and cellular biology

authors： Houshmandi SS,Emnett RJ,Giovannini M,Gutmann DH

更新日期：2009-03-01 00:00:00

abstract：:The dorsal protein (DL) regulates the transcriptional activity of several genes that determine cell fate along the dorsoventral axis of the Drosophila melanogaster embryo. DL is present at high levels in ventral nuclei, where it activates some genes (twi and sna) and represses others (zen, dpp, and tld). DL shows homo...

journal_title：Molecular and cellular biology

authors： Kirov N,Childs S,O'Connor M,Rushlow C

更新日期：1994-01-01 00:00:00

abstract：:Tristetraprolin (TTP) acts by binding to AU-rich elements in certain mRNAs, such as tumor necrosis factor (TNF) mRNA, and increasing their decay rates. TTP knockout mice exhibit a profound inflammatory syndrome that is largely due to increased TNF levels. Although TTP's effects on gene expression have been well studie...

journal_title：Molecular and cellular biology

authors： Patial S,Stumpo DJ,Young WS 3rd,Ward JM,Flake GP,Blackshear PJ

更新日期：2016-04-15 00:00:00

abstract：:Human ras genes play central roles in coupling extracellular signals with complex intracellular networks controlling proliferation, differentiation, and apoptosis, among others processes. c-H-ras pre-mRNA can be alternatively processed into two mRNAs due to the inclusion or exclusion of the alternative exon IDX; this ...

journal_title：Molecular and cellular biology

authors： Guil S,Gattoni R,Carrascal M,Abián J,Stévenin J,Bach-Elias M

更新日期：2003-04-01 00:00:00

abstract：:This is the first study reporting the inactivation of a member of the mouse gene family of toxin-related ecto-ADP-ribosyltransferases (ARTs). Transfer of the ADP-ribose moiety from NAD onto extracellular arginine residues on T-cell membrane proteins is mediated by glycosylphosphatidylinositol-linked cell surface ARTs....

journal_title：Molecular and cellular biology

authors： Ohlrogge W,Haag F,Löhler J,Seman M,Littman DR,Killeen N,Koch-Nolte F

更新日期：2002-11-01 00:00:00

abstract：:Unintended DNA rearrangements in a differentiating lymphocyte can have severe, oncogenic consequences, but the mechanisms for avoiding pathogenic outcomes in V(D)J recombination are not well understood. The first level at which fidelity is instituted is in discrimination by the recombination proteins between authentic...

journal_title：Molecular and cellular biology

authors： Agard EA,Lewis SM

更新日期：2000-07-01 00:00:00

abstract：:An interferon-alpha-like sequence was isolated from a human genomic library by hybridization with a 15-base oligonucleotide. The sequence also showed homology to alpha-interferon and was most closely related to the leukocyte interferon-M gene fragment. The original isolate cross-hybridized to a family of sequences, 10...

journal_title：Molecular and cellular biology

authors： Feinstein SI,Mory Y,Chernajovsky Y,Maroteaux L,Nir U,Lavie V,Revel M

更新日期：1985-03-01 00:00:00

abstract：:Clearance of apoptotic cells by phagocytic neighbors is crucial for normal development of multicellular organisms. However, how phagocytes discriminate between healthy and dying cells remains poorly understood. We focus on glial phagocytosis of apoptotic neurons during development of the Drosophila central nervous sys...

journal_title：Molecular and cellular biology

authors： Shklyar B,Levy-Adam F,Mishnaevski K,Kurant E

更新日期：2013-08-01 00:00:00

abstract：:The baker's yeast Saccharomyces cerevisiae possesses a single gene encoding heat shock transcription factor (HSF), which is required for the activation of genes that participate in stress protection as well as normal growth and viability. Yeast HSF (yHSF) contains two distinct transcriptional activation regions locate...

journal_title：Molecular and cellular biology

authors： Santoro N,Johansson N,Thiele DJ

更新日期：1998-11-01 00:00:00

abstract：:RNase H1 in mammalian cells is present in nuclei and mitochondria. Its absence in mitochondria results in embryonic lethality due to the failure to amplify mitochondrial DNA (mtDNA). Dual localization to mitochondria and nuclei results from differential translation initiation at two in-frame AUGs (M1 and M27) of a sin...

journal_title：Molecular and cellular biology

authors： Suzuki Y,Holmes JB,Cerritelli SM,Sakhuja K,Minczuk M,Holt IJ,Crouch RJ

更新日期：2010-11-01 00:00:00

abstract：:In this report we described the cloning and characterization of ADA5, a gene identified by resistance to GAL4-VP16-mediated toxicity. ADA5 binds directly to the VP16 activation domain but not to a transcriptionally defective VP16 double point mutant. Double mutants with mutations in ada5 and other genes (ada2 or ada3)...

journal_title：Molecular and cellular biology

authors： Marcus GA,Horiuchi J,Silverman N,Guarente L

更新日期：1996-06-01 00:00:00

abstract：:Gene targeting is a very powerful tool for studying mammalian development and physiology and for creating models of human diseases. In many instances, however, it is desirable to study different modifications of a target gene, but this is limited by the generally low frequency of homologous recombination in mammalian ...

journal_title：Molecular and cellular biology

authors： Cohen-Tannoudji M,Robine S,Choulika A,Pinto D,El Marjou F,Babinet C,Louvard D,Jaisser F

更新日期：1998-03-01 00:00:00

abstract：:Understanding the mechanisms that drive the differentiation of dopaminergic (DA) neurons is crucial for successful development of novel therapies for Parkinson's disease, in which DA neurons progressively degenerate. However, the mechanisms underlying the differentiation-promoting effects of Wnt5a on DA precursors are...

journal_title：Molecular and cellular biology

authors： Čajánek L,Ganji RS,Henriques-Oliveira C,Theofilopoulos S,Koník P,Bryja V,Arenas E

更新日期：2013-01-01 00:00:00

abstract：:The C-terminal domain of the RNA polymerase II largest subunit (the Rpb1 CTD) is composed of tandem heptad repeats of the consensus sequence Y(1)S(2)P(3)T(4)S(5)P(6)S(7). We reported previously that Thr 4 is phosphorylated and functions in histone mRNA 3'-end formation in chicken DT40 cells. Here, we have extended our...

journal_title：Molecular and cellular biology

authors： Hsin JP,Xiang K,Manley JL

更新日期：2014-07-01 00:00:00

abstract：:We demonstrate that ATF3, a member of the ATF/CREB family of transcription factors, is induced in a variety of stressed tissues: mechanically injured liver, toxin-injured liver, blood-deprived heart, and postseizure brain. We also demonstrate that an ATF3-interacting protein, gadd153/Chop10, forms a nonfunctional hete...

journal_title：Molecular and cellular biology

authors： Chen BP,Wolfgang CD,Hai T

更新日期：1996-03-01 00:00:00

abstract：:Osteoclasts are bone-resorbing cells essential for skeletal development, homeostasis, and regeneration. They derive from hematopoietic progenitors in the monocyte/macrophage lineage and differentiate in response to RANKL. However, the precise nature of osteoclast progenitors is a longstanding and important question. U...

journal_title：Molecular and cellular biology

authors： Wei W,Zeve D,Wang X,Du Y,Tang W,Dechow PC,Graff JM,Wan Y

更新日期：2011-12-01 00:00:00

abstract：:A sequence-specific DNA-binding protein from skeletal-muscle extracts that binds to probes of three muscle gene DNA elements is identified. This protein, referred to as muscle factor 3, forms the predominant nucleoprotein complex with the MCAT gene sequence motif in an electrophoretic mobility shift assay. This protei...

journal_title：Molecular and cellular biology

authors： Santoro IM,Yi TM,Walsh K

更新日期：1991-04-01 00:00:00

abstract：:SATB1 is expressed primarily in thymocytes and orchestrates temporal and spatial expression of a large number of genes in the T-cell lineage. SATB1 binds to the bases of chromatin loop domains in vivo, recognizing a special DNA context with strong base-unpairing propensity. The majority of thymocytes are eliminated by...

journal_title：Molecular and cellular biology

authors： Galande S,Dickinson LA,Mian IS,Sikorska M,Kohwi-Shigematsu T

更新日期：2001-08-01 00:00:00

abstract：:The alternatively spliced 290-nucleotide NS2-specific exon of the parvovirus minute virus of mice (MVM), which is flanked by a large intron upstream and a small intron downstream, constitutively appears both in the R1 mRNA as part of a large 5'-terminal exon (where it is translated in open reading frame 3 [ORF3]), and...

journal_title：Molecular and cellular biology

authors： Gersappe A,Pintel DJ

更新日期：1999-01-01 00:00:00

abstract：:Histone methylation is an important posttranslational modification that contributes to chromatin-based processes including transcriptional regulation, DNA repair, and epigenetic inheritance. In the budding yeast Saccharomyces cerevisiae, histone lysine methylation occurs on histone H3 lysines 4, 36, and 79, and its de...

journal_title：Molecular and cellular biology

authors： Klose RJ,Gardner KE,Liang G,Erdjument-Bromage H,Tempst P,Zhang Y

更新日期：2007-06-01 00:00:00

abstract：:Vascular smooth muscle cells (vSMCs) are key in the regulation of blood pressure and the engagement of vascular pathologies, such as hypertension, arterial remodeling, and neointima formation. The role of the Rac1 GTPase in these cells remains poorly characterized. To clarify this issue, we have utilized genetically e...

journal_title：Molecular and cellular biology

authors： Fabbiano S,Menacho-Márquez M,Sevilla MA,Albarrán-Juárez J,Zheng Y,Offermanns S,Montero MJ,Bustelo XR

更新日期：2014-12-01 00:00:00