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Paradoxical effects of pirenzepine on parasympathetic activity in chronic heart failure and control.

Abstract：

:We studied the effect of intravenous pirenzepine (3 mg) in normal subjects (n=15, 43+/-16 years old) and in patients with chronic heart failure (n=15, 61+/-12 years old) to assess the effect of low-dose pirenzepine on vagal activity. R-R intervals and the standard deviations, low-frequency power (LF: ln ms2, 0.04-0.15 Hz), high-frequency power (HF: ln ms2, 0.15-0.40 Hz) and the ratio of low- to high-frequency power (LF/HF ratio) were measured 10 min before and after pirenzepine using a Holter analysis system. Pirenzepine was found to cause a significant increase in the R-R interval from 903+/-112 to 956+/-129 ms in the control group (P<0.0001) and from 927+/-141 to 958+/-168 ms in patients with chronic heart failure (P<0.01). Pirenzepine also increased HF significantly from 4.29+/-0.32 to 5.16+/-0.38 ln ms2 in the control group (P<0.0001) and from 4.04+/-0.16 to 4.48+/-0.24 ln ms2 in the chronic heart failure group (P<0.05). Pirenzepine did not significantly alter the LF/HF ratio in either group. We emphasize that pirenzepine appears to have a vagoinimetic effect in patients with chronic heart failure and that it may be useful for augmenting vagal control of the heart in some patients with chronic heart failure.

journal_name

Int J Cardiol

journal_title

International journal of cardiology

authors

Hayano T,Shimizu A,Ikeda Y,Yamamoto T,Yamagata T,Ueyama T,Furutani Y,Matsuzaki M

doi

10.1016/s0167-5273(98)00335-0

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

47-56

issue

1

eissn

0167-5273

issn

1874-1754

pii

S0167527398003350

journal_volume

68

pub_type

杂志文章

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