Abstract：
:In the clinical literature there are reports of patients failing to breathe and becoming comatose when supplied with 100% oxygen for respiratory distress. This effect has been attributed to a loss of respiratory drive. Recent studies have established that this explanation is incorrect, but have left the phenomenon unexplained. We propose that the apnea and coma reported is due to carbon dioxide narcosis. We have reproduced this effect in an animal model and have documented PCO2 values in excess of 250 mmHg during the apneic period. Our results suggest that this level of PCO2 suppresses both brainstem auditory evoked potentials and spontaneous respiration. The high PCO2 is due to inadequate gas exchange, and is easily remedied by provision of adequate ventilation.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Reid KH,Patenaude B,Guo SZ,Iyer VGdoi
10.1016/s0300-9572(98)00096-3subject
Has Abstractpub_date
1998-09-01 00:00:00pages
185-91issue
3eissn
0300-9572issn
1873-1570pii
S0300957298000963journal_volume
38pub_type
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