Abstract:
PURPOSE:Although well characterized in animals, brain damage in humans treated with hypothermia after cardiac arrest has not been systematically explored. In this study we aimed to describe the characteristic trait of selective eosinophilic neuronal death (SEND), and its correlation with time to return of spontaneous circulation (ROSC) in cardiac arrest patients who died after hypothermia treatment and were referred for autopsy. METHODS:Brain autopsy microscopic slides and clinical data were gathered from 23 non-survivors of cardiac arrest who were treated with hypothermia. Based on the percentage of eosinophilic neurons, a damage score 0-4 was given in 6 brain regions, and a total damage score was calculated. The damage score was correlated with time to ROSC and with neuron-specific enolase (NSE) in peripheral blood at 48 h post arrest. RESULTS:Hippocampus had the highest damage score with a median of 3 (inter-quartile range 2-4) while the brainstem had the lowest median damage score of 0 (0-2). Total damage score showed the best correlation with time to ROSC (Spearman Rho=0.66). Serum NSE values >33 μg/L (n=6) was associated with significantly higher mean damage score than NSE <33 μg/L (n=9) (p=0.002). CONCLUSION:This is the first study to systematically describe regional SEND in patients treated with hypothermia after cardiac arrest. Hippocampus was the most vulnerable region whereas the brainstem was the most resistant. Although not directly compared here, the regional pattern of SEND seems not to be altered by hypothermia treatment, but maintains its profile distinctive for cardiac arrest pathogenesis.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Björklund E,Lindberg E,Rundgren M,Cronberg T,Friberg H,Englund Edoi
10.1016/j.resuscitation.2013.11.022subject
Has Abstractpub_date
2014-04-01 00:00:00pages
527-32issue
4eissn
0300-9572issn
1873-1570pii
S0300-9572(13)00885-Xjournal_volume
85pub_type
杂志文章相关文献
RESUSCITATION文献大全abstract:BACKGROUND:The European Resuscitation Council Guidelines 2015 recommend bystanders to activate their mobile phone speaker function, if possible, in case of suspected cardiac arrest. This is to facilitate continuous dialogue with the dispatcher including (if required) cardiopulmonary resuscitation instructions. The aim ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2017.04.002
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Despite significant advances in resuscitation efforts, there are some patients who remain in ventricular fibrillation (VF) after multiple shocks during out-of-hospital cardiac arrest (OHCA). Double sequential external defibrillation (DSED) has been proposed as a treatment option for patients in refractory VF...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2019.04.038
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:Prolonged chest compression interruptions immediately preceding and following a defibrillation shock reduce shock success and survival after cardiac arrest. We tested the hypothesis that compression pauses would be shorter using an AED equipped with a new Analysis during Compressions with Fast Reconfirmation (A...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2015.02.025
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The electroencephalograph (EEG) pattern of burst suppression with identical bursts (BSIB), with or without myoclonus, occurs often after resuscitation from cardiac arrest. These patterns are associated with severe brain injury but their neuropathological basis is unknown. Using EEG source localization, we te...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2020.10.029
更新日期:2020-10-27 00:00:00
abstract:PURPOSE:Incorrect resuscitation after hypovolemic shock is a major contributor to preventable pediatric death. Several studies have demonstrated that small volumes of hypertonic or hypertonic-hyperoncotic saline can be an effective initial resuscitation solution. However, there are no pediatric studies to recommend the...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2012.02.003
更新日期:2012-09-01 00:00:00
abstract:PURPOSE:Arterial hyperoxia after resuscitation has been associated with increased mortality in adults. The aim of this study was to test the hypothesis that post-resuscitation hyperoxia and hypocapnia are associated with increased mortality after resuscitation in pediatric patients. METHODS:We performed a prospective ...
journal_title:Resuscitation
pub_type: 杂志文章,多中心研究
doi:10.1016/j.resuscitation.2012.07.019
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Placement of the defibrillation electrodes affects the transmyocardial current and thus the success of a defibrillation attempt. In the international guidelines 2000, the placement of the apical electrode was changed more laterally to the mid-axillary line. Finnish national guidelines, based on the internati...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2004.01.004
更新日期:2004-05-01 00:00:00
abstract::Cross-clamping of the ascending aorta in dogs for 15 min produced severe neurological deficit, observed for up to 20 h. Immediately after restoration of the circulation, the intracranial pressure in the cisterna magna increased transiently to a mean peak of 22.8 Torr (SD +/- 1.7) because of a compensatory increase in ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(75)90071-4
更新日期:1975-01-01 00:00:00
abstract:AIM:To compare the time-dependent changes in the quality of chest compressions in 30:2 cardiopulmonary resuscitation (CPR) and hands-only cardiopulmonary resuscitation (HO-CPR) and to evaluate how individual rescuer factors affect the quality of chest compressions over time for both CPR techniques. METHODS:Total 1028 ...
journal_title:Resuscitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.resuscitation.2011.11.006
更新日期:2012-03-01 00:00:00
abstract:AIM:The aim of this study was to investigate the levels of various cerebrospinal fluid (CSF) biomarkers related to neuronal damage, inflammation and amyloid β (Aβ) metabolism in patients resuscitated after an out-of-hospital cardiac arrest (CA). METHODS:CSF levels of neurofilament light protein (NFL), total tau (T-tau...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2013.10.032
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:It has been shown that a computer-based audible feedback system can improve acquisition and retention of basic life support (BLS) skills. This system is being developed to work in association with an automated external defibrillator (AED). AIM:To determine if such a feedback system is likely to improve the ...
journal_title:Resuscitation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0300-9572(02)00400-8
更新日期:2003-04-01 00:00:00
abstract:AIM:Evaluate the roles of water temperature and submersion duration in the outcome of drowning victims. METHODS:Subjects were those who drowned in open water (lakes, rivers, and ocean) in three counties in Washington State between 1975 and 1996. We performed a case control study to assess the association between age, ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2014.02.024
更新日期:2014-06-01 00:00:00
abstract:AIM OF THE STUDY:Airway management in an out-of-hospital setting is a critical and demanding skill. Previous studies evaluated the intubating laryngeal mask airway (ILMA) as a valuable tool in this area. The LMA CTrach Laryngeal Mask Airway (CTrach) may increase intubation success. Therefore, we evaluated the CTrach as...
journal_title:Resuscitation
pub_type: 临床试验,杂志文章
doi:10.1016/j.resuscitation.2008.06.020
更新日期:2008-11-01 00:00:00
abstract::A 52-year-old previously healthy man experienced acute severe dyspnoea after suffering from gastroenteritis for 3 days. After arrival of the ambulance, cardiac arrest with an initial rhythm of electro mechanical dissociation occurred. Circulation was restored after 10 min of cardiopulmonary resuscitation but soon card...
journal_title:Resuscitation
pub_type: 杂志文章,评审
doi:10.1016/s0300-9572(98)00066-5
更新日期:1998-07-01 00:00:00
abstract::Recent evidence suggests that the current ILCOR guidelines regarding hypothermia for the treatment of neonatal encephalopathy need urgent revision. In 2005 when the current ILCOR guidelines were finalised one large (CoolCap trial, n=235) and one small RCT (n=67), in addition to pilot trials, had been published, and de...
journal_title:Resuscitation
pub_type: 杂志文章,评审
doi:10.1016/j.resuscitation.2008.04.027
更新日期:2008-07-01 00:00:00
abstract:AIM:To describe the change in the occurrence of ventricular fibrillation as initially observed arrhythmia among patients suffering from out-of-hospital cardiac arrest in Sweden. PATIENTS:All patients included in the Swedish cardiac arrest registry between 1991 until 2001. The registry covers 85% of the population in S...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2003.11.003
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:few studies have compared the discrimination of predictive scores of in-hospital mortality that used vital signs with those using laboratory results in different patient populations. METHODS:a hypothesis generating retrospective observational cohort study. A score that only used vital signs was compared wit...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2016.02.020
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:Spontaneous subarachnoid haemorrhage as a cause of out-of-hospital cardiac arrest is poorly evaluated. We analyse disease-specific and emergency care data in order to improve the recognition of subarachnoid haemorrhage as a cause of cardiac arrest. DESIGN:We searched a registry of cardiac arrest patients adm...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/s0300-9572(01)00381-1
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Despite its prevalence, survival from out-of-hospital cardiac arrest remains low. High quality CPR has been associated with improved survival in cardiac arrest patients. In early 2014, a program was initiated to provide feedback on CPR quality to prehospital providers after every treated cardiac arrest. OBJ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2017.02.004
更新日期:2017-04-01 00:00:00
abstract:AIM:To evaluate the gonadal hormones in patients with return of spontaneous circulation (ROSC) after cardiac arrest following prospectively good (cerebral-performance category [CPC] 1-2) and poor (CPC 3-5) neurologic outcomes. METHODS:The patients in an emergency center who had been admitted to the center's intensive ...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2012.10.022
更新日期:2013-05-01 00:00:00
abstract:AIM OF THE STUDY:To investigate whether pure self-learning without instructor support, resulted in the same BLS-competencies as facilitator-led learning, when using the same commercially available video BLS teaching kit. METHODS:First-year medical students were randomised to either BLS self-learning without supervisio...
journal_title:Resuscitation
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.resuscitation.2018.02.031
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:Evaluate the prevalence of fever in the first 48 h after cardiac arrest and its effect on outcomes. METHODS:Review of patients treated between 1/1/2005 and 6/30/2010. Fever was defined as T ≥ 38.0°C. We classified categories of post-cardiac arrest illness severity as (I) awake, (II) coma+mild cardiopulmonary...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2013.03.038
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:Recommendations for extracorporeal cardiopulmonary resuscitation (ECPR) state that appropriate patient selection is important for the sake of efficacy and cost-effectiveness of ECPR. It is not known whether first documented rhythm plays a prominent role in economic outcomes of patients with cardiac arrest wh...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2019.05.013
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Sudden cardiac arrest (SCA) is a major public health challenge in the United States (US). At present, the existence of limited literature on psychological sequelae post-cardiac arrest is a challenge in providing optimal care to survivors. AIM:The aim of this study is to determine the prevalence of various p...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2019.01.035
更新日期:2019-03-01 00:00:00
abstract::Respiratory distress, from severe gastric aspiration pneumonitis and abdominal distention in the patient with tracheoesophageal fistula frequently requires mechanical ventilatory support. Bulk flow ventilation can lead to enlargement of the fistulous tract, elevation of gastric intraluminal pressures, raised airway pr...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/0300-9572(85)90001-2
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND:Comatose survivors of out-of-hospital cardiac arrest (OHCA) have high in-hospital mortality due to a complex pathophysiology that includes cardiovascular dysfunction, inflammation, coagulopathy, brain injury and persistence of the precipitating pathology. Therapeutic hypothermia (TH) is the only intervention...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2008.12.015
更新日期:2009-04-01 00:00:00
abstract:INTRODUCTION:Clinical teams struggle on general wards with acute management of deteriorating patients. We hypothesized that the Crisis Checklist App, a mobile application containing checklists tailored to crisis-management, can improve teamwork and acute care management. METHODS:A before-and-after study was undertaken...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2020.09.031
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of HBOC-201 for resuscitation of hemorrhagic shock in a swine model incorporating soft tissue injury and delayed evacuation. METHODS:A muscle crush injury and 40% estimated blood volume controlled hemorrhage was completed in 24 Yucatan mini-pigs. Pigs were untreated or resuscitated w...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2005.03.019
更新日期:2005-09-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to investigate regional variation in the characteristics, incidence and outcomes of out-of-hospital cardiac arrest (OHCA) in Australia and New Zealand. METHODS:This was a population-based cohort study of OHCA using data from the Aus-ROC Australian and New Zealand OHCA Epistry ove...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2018.02.029
更新日期:2018-05-01 00:00:00
abstract:INTRODUCTION:Quality chest compressions (CC) are the most important factor in successful cardiopulmonary resuscitation. Adjustment of CC based upon an invasive arterial blood pressure (ABP) display would be theoretically beneficial. Additionally, having one compressor present for longer than a 2-min cycle with an ABP d...
journal_title:Resuscitation
pub_type: 杂志文章
doi:10.1016/j.resuscitation.2013.06.014
更新日期:2013-11-01 00:00:00