Abstract：
AIM:The aim of this study was to investigate the levels of various cerebrospinal fluid (CSF) biomarkers related to neuronal damage, inflammation and amyloid β (Aβ) metabolism in patients resuscitated after an out-of-hospital cardiac arrest (CA). METHODS:CSF levels of neurofilament light protein (NFL), total tau (T-tau), hyperphosphorylated tau (P-tau), YKL-40, Aβ38, Aβ40, Aβ42, soluble amyloid precursor protein α and β (sAPPα and sAPPβ) were measured in 21 patients approximately two weeks after CA and in 21 age-matched neurologically healthy controls. The biomarker levels were also compared between patients with good and poor long-term clinical outcome according to Glasgow Outcome Scale (GOS), activities of daily living (ADL) and mini-mental state examination (MMSE), measuring neurologic function, daily functioning and cognitive function, respectively. RESULTS:Patients with CA had a very marked increase in the CSF levels of NFL, T-tau and YKL-40 as compared with controls. The levels were increased at about 1200, 700 and 100%, respectively. NFL and T-tau were significantly higher in patients with poor outcome according to all three outcome measures. Patients with poor outcome according to GOS and ADL had higher levels of YKL-40. Levels of Aβ38, Aβ40, Aβ42, sAPPα and sAPPβ were lower in patients with a low MMSE score. P-tau was not significantly altered. CONCLUSIONS:Biomarkers reflecting neuronal damage and inflammation, but not so much Aβ metabolism, were significantly altered in patients after a CA, and the changes were more pronounced in the groups with poor outcome. This calls for future larger studies to determine the prognostic potential of these biomarkers.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Rosén C,Rosén H,Andreasson U,Bremell D,Bremler R,Hagberg L,Rosengren L,Blennow K,Zetterberg Hdoi
10.1016/j.resuscitation.2013.10.032subject
Has Abstractpub_date
2014-02-01 00:00:00pages
227-32issue
2eissn
0300-9572issn
1873-1570pii
S0300-9572(13)00840-Xjournal_volume
85pub_type
杂志文章相关文献
RESUSCITATION文献大全abstract：AIM:To analyze the relationship between the depth of the chest compressions and the fluctuation caused in the thoracic impedance (TI) signal in out-of-hospital cardiac arrest (OHCA). The ultimate goal was to evaluate whether it is possible to identify compressions with inadequate depth using information of the TI wavef...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2013.12.035
更新日期：2014-05-01 00:00:00
abstract：:We challenged the current management of uncontrolled haemorrhagic shock (UHS) and put forward a hypothesis that therapeutic mild hypothermia combined with delayed fluid resuscitation will improve the survival rate. After an initial blood withdrawal of 3 ml/100g for 15 min, the rat's tail was amputated up to 75% to ind...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2004.04.009
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:Sudden cardiac arrest (SCA) is a major public health challenge in the United States (US). At present, the existence of limited literature on psychological sequelae post-cardiac arrest is a challenge in providing optimal care to survivors. AIM:The aim of this study is to determine the prevalence of various p...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2019.01.035
更新日期：2019-03-01 00:00:00
abstract：AIM:Extracorporeal cardiopulmonary resuscitation (ECPR) is an emerging therapy for refractory cardiac arrest. The purpose of this study was to analyze and report characteristics and outcomes of adult patients treated with ECPR after out-of-hospital cardiac arrest (OHCA) in a large international registry. METHODS:The E...
journal_title：Resuscitation
pub_type： 杂志文章,多中心研究
doi：10.1016/j.resuscitation.2017.08.003
更新日期：2017-10-01 00:00:00
abstract：AIMS:Acute coronary lesions are known to be the most common trigger of out of hospital cardiac arrest (OHCA). Aim of the present study was to assess the predictive value of ST-segment changes in diagnosing the presence of acute coronary lesions among OHCA patients METHODS:Findings of coronary angiography (CA) performe...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2013.04.023
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVES:Emergency echocardiography (EM echo) has been proposed to assist in decision-making in patients with pulseless electric activity (PEA) or PEA-like states. We observed the value of EM echo by emergency physicians in detecting pericardial effusion in patients in PEA and near PEA states. MATERIALS AND METHODS:...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(03)00245-4
更新日期：2003-12-01 00:00:00
abstract：AIM:We aimed to describe characteristics associated with rescue from drowning as reported by the Swedish Fire and Rescue Services (SFARS) and their association with survival from the Out of Hospital Cardiac Arrest (OHCA) registry. METHOD:This retrospective study is based on the OHCA registry and the Swedish Civil Cont...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2012.05.025
更新日期：2012-09-01 00:00:00
abstract：AIM:We decided to evaluate the life situation of the survivors after out-of-hospital cardiopulmonary resuscitation (CPR). METHOD:CPR survivors who were 75 years or younger at the time and who were discharged alive from the hospital were identified consecutively. Average follow-up time was 25.5 months, and at follow-up...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(95)00903-5
更新日期：1996-04-01 00:00:00
abstract：INTRODUCTION:Implementing prehospital advanced life support (ALS) services requires more medical and societal resources in training and equipment. The actual demand for ALS services in our communities was not clear. To ensure good use of expensive resources, it is important to evaluate the demand and appropriateness of...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2006.03.016
更新日期：2006-11-01 00:00:00
abstract：:In-hospital emergency medicine in central Europe relies on inter-disciplinary co-operation. To improve team performance in the emergency room (ER), a questionnaire for assessment of attitudes and judgements in resuscitation procedures was developed. A total of 43 items were evaluated according to a five-point Likert s...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(00)00304-x
更新日期：2001-04-01 00:00:00
abstract：OBJECTIVE:Shockable cardiac rhythms are associated with improved outcomes among out-of-hospital cardiac arrests (OHCA). Initial cardiac rhythm may also be predictive of a short preceding no-flow duration. We examined the relationship between no-flow duration and initial cardiac rhythm, which may demonstrate the urgency...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2018.05.002
更新日期：2018-07-01 00:00:00
abstract：PURPOSE:An arterial blood gas analysis (ABG) yields important diagnostic information in the management of cardiac arrest. This study evaluated ABG samples obtained during out-of-hospital cardiopulmonary resuscitation (OHCPR) in the setting of a prospective multicenter trial. We aimed to clarify prospectively the ABG ch...
journal_title：Resuscitation
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.resuscitation.2016.06.013
更新日期：2016-09-01 00:00:00
abstract：INTRODUCTION:The combination of the LUCAS 2 (L-CPR) automated CPR device and an impedance threshold device (ITD) has been widely implemented in the clinical field. This animal study tested the hypothesis that the addition of an ITD on L-CPR would enhance cerebral and coronary perfusion pressures. METHODS:Ten female pi...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2014.09.013
更新日期：2014-12-01 00:00:00
abstract：AIM:To review the literature surrounding various aspects of T-piece resuscitator use, with particular emphasis on the evidence comparing the device to other manual ventilation devices in neonatal resuscitation. DATA SOURCES:The Medline, EMBASE, Cochrane databases were searched in April 2011. Ongoing trials were identi...
journal_title：Resuscitation
pub_type： 杂志文章,评审
doi：10.1016/j.resuscitation.2011.12.020
更新日期：2012-07-01 00:00:00
abstract：INTRODUCTION:Telephone-cardiopulmonary resuscitation (CPR) advice aims to increase the quality and quantity of bystander CPR, one of the few interventions shown to improve outcome in cardiac arrest. We evaluated a current paediatric telephone protocol (AMPDS v11.1) to assess the effectiveness of verbal CPR instructions...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2010.02.007
更新日期：2010-07-01 00:00:00
abstract：INTRODUCTION:The current guidelines of the European Resuscitation Council (ERC) stipulate that an intraosseous access should be placed if establishing a peripheral venous access for cardiopulmonary resuscitation (CPR) would involve delays. The aim of this study was therefore to compare a manual intraosseous infusion te...
journal_title：Resuscitation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.resuscitation.2008.04.004
更新日期：2008-09-01 00:00:00
abstract：INTRODUCTION:Bystander cardiopulmonary resuscitation (CPR) significantly improves the outcome from sudden cardiac arrest (SCA) and is therefore encouraged by offering telephone instructions to the bystander. The effectiveness of this technique was examined in a manikin-based study. METHODS:Subjects performed CPR on an...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2006.07.025
更新日期：2007-03-01 00:00:00
abstract：OBJECTIVES:To determine emergency department (ED) staff preference for one- or two-handed paediatric chest compressions and to determine if there was a difference in compression rates delivered and fatigability between the techniques. METHODS:This was a randomised, cross-over observational study of paediatric CPR perf...
journal_title：Resuscitation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.resuscitation.2006.02.007
更新日期：2006-10-01 00:00:00
abstract：OBJECTIVES:The timing of and interval between events in prehospital care is important for system design, patient outcome, and prehospital research. Since these data can guide treatment recommendations, it is imperative that time-based prehospital documentation is accurate and precise, especially for time-sensitive cond...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2014.05.002
更新日期：2014-08-01 00:00:00
abstract：AIM:The American Heart Association (AHA) and the Institute of Medicine have published a national "call-to-action" to improve survival from in-hospital cardiopulmonary arrest (IHCA). Our aim was to determine if more-active hospital participation in standardized in-situ mock code (ISMC) training is associated with increa...
journal_title：Resuscitation
pub_type： 杂志文章,多中心研究
doi：10.1016/j.resuscitation.2018.09.020
更新日期：2018-12-01 00:00:00
abstract：OBJECTIVE:To analyze the results of cardiopulmonary resuscitation (CPR) that included defibrillation during in-hospital cardiac arrest (IH-CA) in children. METHODS:A prospective multicenter, international, observational study on pediatric IH-CA in 12 European and Latin American countries, during 24 months. Data from 5...
journal_title：Resuscitation
pub_type： 杂志文章,多中心研究
doi：10.1016/j.resuscitation.2013.11.015
更新日期：2014-03-01 00:00:00
abstract：:Manikins currently used in newborn and paediatric resuscitation training are limited in their effectiveness by an inability to allow instructors control over airway patency. This means that attempts to introduce situations that require interventions, other than just appropriate head positioning to achieve successful l...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(02)00124-7
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to investigate whether the DOR agonist BW373U86 conferred neuroprotection following ACA when given after resuscitation and to determine the long-term effects of chronic BW373U86 treatment on ACA-elicited brain injury. METHODS:Animals were divided into acute and chronic treatment gro...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2013.10.022
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND:The incidence of ventricular fibrillation (VF) out-of-hospital cardiac arrest (OHCA) treated by first responders has declined over the past decade. Since VF OHCA occurs primarily in the setting of severe coronary artery disease, primary and secondary prevention strategies may in part account for the decline....
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2005.04.015
更新日期：2005-10-01 00:00:00
abstract：AIM:Effective assessment of motor skills in large-size classes is a challenge in medical education. This case-study investigates whether a game can be considered a valid tool for the summative assessment of first aid and basic life support skills. METHODS:Using a traditional exam as bench-mark, a board game format was...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2010.12.003
更新日期：2011-04-01 00:00:00
abstract：AIM:This study investigated temporal trends in the incidence of out-of-hospital cardiac arrests (OHCA) in metropolitan Perth (Western Australia) between 1997 and 2010. METHODS:We calculated crude and age-and-sex-standardised incidence rates (ASIRs) using the 2011 Australian population as the standard population. Incid...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2014.02.017
更新日期：2014-06-01 00:00:00
abstract：OBJECTIVE:To investigate the clinical course and early prognostic markers in cardiac arrest (CA) patients discharged from the intensive care unit (ICU) in an unresponsive wakefulness syndrome (UWS) or coma. METHODS:89 patients were identified from a prospective CA database. Follow-up was conducted by telephone intervi...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2018.07.007
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Point-of-care ultrasound has been suggested to improve outcomes from advanced cardiac life support (ACLS), but no large studies have explored how it should be incorporated into ACLS. Our aim was to determine whether cardiac activity on ultrasound during ACLS is associated with improved survival. METHODS:We ...
journal_title：Resuscitation
pub_type： 杂志文章,多中心研究
doi：10.1016/j.resuscitation.2016.09.018
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Recent data identifies extracorporeal cardio-pulmonary resuscitation (eCPR) as a potential addendum of conventional cardiopulmonary-resuscitation (cCPR) in highly specified circumstances and selected patients. However, consented criteria indicating eCPR are lacking. Therefore we provide first insights into t...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2018.03.036
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Sudden cardiac death during exercise or sports is an important problem among young athletes and non-athletes. An understanding of the epidemiological features of sports-related out-of-hospital cardiac arrest (OHCA) among children is crucial for planning approaches for prevention and better outcomes of paedia...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2019.03.041
更新日期：2019-06-01 00:00:00
