Abstract：
:Recent evidence suggests that the current ILCOR guidelines regarding hypothermia for the treatment of neonatal encephalopathy need urgent revision. In 2005 when the current ILCOR guidelines were finalised one large (CoolCap trial, n=235) and one small RCT (n=67), in addition to pilot trials, had been published, and demonstrated that therapeutic hypothermia after perinatal asphyxia was safe. The CoolCap trial showed a borderline overall effect on death and disability at 18 months of age, but significant improvement in a large subset of infants with less severe electroencephalographic changes. Based on this and other available evidence, the 2005 ILCOR guidelines supported post-resuscitation hypothermia in paediatric patients after cardiac arrest, but not after neonatal resuscitation. Subsequently, a whole body cooling trial supported by the NICHD reported a significant overall improvement in death or disability. Further large neonatal trials of hypothermia have stopped recruitment and their final results are likely to be published 2009-2011. Many important questions around the optimal therapeutic use of hypothermia remain to be answered. Nevertheless, independent meta-analyses of the published trials now indicate a consistent, robust beneficial effect of therapeutic hypothermia for moderate to severe neonatal encephalopathy, with a mean NNT between 6 and 8. Given that there is currently no other clinically proven treatment for infants with neonatal encephalopathy we propose that an interim advisory statement should be issued to support and guide the introduction of therapeutic hypothermia into routine clinical practice.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Hoehn T,Hansmann G,Bührer C,Simbruner G,Gunn AJ,Yager J,Levene M,Hamrick SE,Shankaran S,Thoresen Mdoi
10.1016/j.resuscitation.2008.04.027subject
Has Abstractpub_date
2008-07-01 00:00:00pages
7-12issue
1eissn
0300-9572issn
1873-1570pii
S0300-9572(08)00464-4journal_volume
78pub_type
杂志文章,评审相关文献
RESUSCITATION文献大全abstract：:Cardiac ischemia can present as distinctive clinical syndromes such as acute myocardial infarction, cardiogenic shock, sudden cardiac arrest or chronic congestive heart failure. All of the clinical syndromes share common pathophysiological events including reduction of cardiac output and systemic oxygen delivery (DO2)...
journal_title：Resuscitation
pub_type： 杂志文章,评审
doi：10.1016/0300-9572(94)90065-5
更新日期：1994-12-01 00:00:00
abstract：:In-hospital emergency medicine in central Europe relies on inter-disciplinary co-operation. To improve team performance in the emergency room (ER), a questionnaire for assessment of attitudes and judgements in resuscitation procedures was developed. A total of 43 items were evaluated according to a five-point Likert s...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(00)00304-x
更新日期：2001-04-01 00:00:00
abstract：:Cross-clamping of the ascending aorta in dogs for 15 min produced severe neurological deficit, observed for up to 20 h. Immediately after restoration of the circulation, the intracranial pressure in the cisterna magna increased transiently to a mean peak of 22.8 Torr (SD +/- 1.7) because of a compensatory increase in ...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(75)90071-4
更新日期：1975-01-01 00:00:00
abstract：OBJECTIVE:This study aimed at evaluating two emergency medical service systems, one in which emergency life-saving technicians (ELSTs) are allowed to administer epinephrine (adrenaline) to patients with out-of-hospital cardiac arrest and one in which ELSTs are allowed to administer epinephrine, lidocaine, and atropine....
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2004.10.019
更新日期：2005-07-01 00:00:00
abstract：:One of the pioneers of open chest cardiac massage was Cemil Topuzlu Pasha, in Turkey. He presented his experience in open heart cardiac massage in several papers published in Ottoman and French and German. On 27 August 1903 one of his patients undergoing external urethrotomy under chloroform anaesthesia developed card...
journal_title：Resuscitation
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.resuscitation.2005.07.001
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:The outcome among patients who are hospitalised alive after out-of-hospital cardiac arrest is still relatively poor. At present, there are no clear guidelines specifying how they should be treated. The aim of this survey was to describe the outcome for initial survivors of out-of-hospital cardiac arrest when...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2006.08.018
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Predicting outcome after cardiac arrest (CA) is particularly difficult when therapeutic hypothermia (TH) is used. We investigated the performance of quantitative pupillometry and transcranial Doppler (TCD) in this context. METHODS:This prospective observational study included 82 post-CA patients. Quantitati...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2016.02.026
更新日期：2016-06-01 00:00:00
abstract：OBJECTIVE:Heart rate reduction (HRR) has shown a beneficial impact on the prevention of ventricular fibrillation, which could be explained by increased myocardial blood flow and preservation of mitochondrial structure. Here, we assessed the HRR impact on time to onset of ventricular fibrillation (TOVF) and myocardial m...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2012.07.041
更新日期：2013-03-01 00:00:00
abstract：AIM:Each minute is crucial in the treatment of out-of-hospital cardiac arrest (CA). Immediate chest compressions and early defibrillation are keys to good outcomes. We hypothesized that a coordinated effort of alerting trained local neighborhood volunteers (vols) simultaneously with 911 activation of professional EMS p...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2019.09.016
更新日期：2019-11-01 00:00:00
abstract：CONTEXT:Extracorporeal cardiopulmonary resuscitation (ECPR) refers to emergent percutaneous veno-arterial cardiopulmonary bypass to stabilize and provide temporary support of patients who suffer cardiopulmonary arrest. Initiation of ECPR by emergency physicians with meaningful long-term patient survival has not been de...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2012.01.027
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:The Recommended Summary Plan for Emergency Care and Treatment (ReSPECT) is an emergency care and treatment planning (ECTP) process, developed to offer a patient-centred approach to deciding about and recording treatment recommendations. Conversations between clinicians and patients or their representatives a...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2021.01.013
更新日期：2021-01-19 00:00:00
abstract：:The International Liaison Committee on Resuscitation (ILCOR), with representation from North America, Europe, Australia, New Zealand, Africa, and South America, was formed in 1992 to provide a forum for liaison between resuscitation organizations in the developed world. This consensus document on resuscitation extends...
journal_title：Resuscitation
pub_type： 共识发展会议,指南,杂志文章,实务指引,评审
doi：10.1016/s0300-9572(99)00012-x
更新日期：1999-02-01 00:00:00
abstract：:Mild to moderate hypothermia has been employed since the 1940s in the treatment of acute blunt head trauma. The utility of hypothermia in ischemic injury has been confirmed, by both animal studies and clinical experience, in cardiovascular and neurological surgery. In blunt injury, though, only one prospective, random...
journal_title：Resuscitation
pub_type： 杂志文章,评审
doi：10.1016/0300-9572(94)90049-3
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:For prolonged VF, perfusion of the myocardium by pre-shock chest compressions can improve myocardial readiness for successful defibrillation. Characteristics of the VF waveform correlate with the duration of VF when there is no structural heart disease. A "smart" automated external defibrillator (AED) could ...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2005.10.017
更新日期：2006-06-01 00:00:00
abstract：BACKGROUND:Cardiopulmonary resuscitation (CPR) using extracorporeal life support (ECLS) system has been successfully used to support patients with in- and out-of-hospital cardiac arrest (IHCA, OHCA) when conventional measures have failed. The purpose of the current study is to report on our experience with extracorpore...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2012.07.009
更新日期：2012-11-01 00:00:00
abstract：:The dose of drugs used in pediatric resuscitation is one of the greatest sources of problems. Usually, each drug has a different recommended dosage in mg/kg weight and a different presentation in mg/ml in the ampoule. We suggested a simple solution to simplify drug use in the emergency: we established a common dose of...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(03)00210-7
更新日期：2003-11-01 00:00:00
abstract：AIM OF THE STUDY:A reproducible long-term intensive care and outcome cardiac arrest model for exploring new cerebral preservation strategies is needed. We tried to determine effects and limitations of current therapies after different 'no-flow' times. METHODS:Thirty-five female Large White Breed pigs (26-37kg) were in...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2010.08.040
更新日期：2011-01-01 00:00:00
abstract：:The completeness of brain ischemia with a multi-arterial clamping method in dogs was examined using EEG, evoked potentials (EPs) and vessel staining with Evans blue. EEG was monitored by bipolar parietal lead. EPs stimulating electrodes were inserted into the first thoracic (T1) epidural space and recording electrodes...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(91)90031-s
更新日期：1991-12-01 00:00:00
abstract：:We report the first case of amitriptyline toxicity treated with intravenous fat emulsion (IFE). Toxicity was manifested as vasopressor-refractory haemodynamic instability despite standard therapy. Our patient recovered with no adverse effects noted. ...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2010.04.009
更新日期：2010-08-01 00:00:00
abstract：AIM:To review the literature surrounding various aspects of T-piece resuscitator use, with particular emphasis on the evidence comparing the device to other manual ventilation devices in neonatal resuscitation. DATA SOURCES:The Medline, EMBASE, Cochrane databases were searched in April 2011. Ongoing trials were identi...
journal_title：Resuscitation
pub_type： 杂志文章,评审
doi：10.1016/j.resuscitation.2011.12.020
更新日期：2012-07-01 00:00:00
abstract：AIM:The American Heart Association (AHA) and the Institute of Medicine have published a national "call-to-action" to improve survival from in-hospital cardiopulmonary arrest (IHCA). Our aim was to determine if more-active hospital participation in standardized in-situ mock code (ISMC) training is associated with increa...
journal_title：Resuscitation
pub_type： 杂志文章,多中心研究
doi：10.1016/j.resuscitation.2018.09.020
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:The incidence of ventricular fibrillation (VF) as the presenting rhythm in out-of-hospital cardiac arrest (OHCA) is declining, whereas pulseless electrical activity (PEA) is increasing. This changing epidemiology has occurred concomitant with an increase in beta-blocker use. AIMS:The aim of this study was t...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2007.08.022
更新日期：2008-03-01 00:00:00
abstract：AIM:This study investigated temporal trends in the incidence of out-of-hospital cardiac arrests (OHCA) in metropolitan Perth (Western Australia) between 1997 and 2010. METHODS:We calculated crude and age-and-sex-standardised incidence rates (ASIRs) using the 2011 Australian population as the standard population. Incid...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2014.02.017
更新日期：2014-06-01 00:00:00
abstract：CONTEXT:The impact of clinical experience on learning outcome from a resuscitation course has not been systematically investigated. AIM:To determine whether half a year of clinical experience before participation in an Advanced Life Support (ALS) course increases the immediate learning outcome and retention of learnin...
journal_title：Resuscitation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.resuscitation.2008.10.026
更新日期：2009-02-01 00:00:00
abstract：INTRODUCTION:Bystander cardiopulmonary resuscitation (CPR) significantly improves the outcome from sudden cardiac arrest (SCA) and is therefore encouraged by offering telephone instructions to the bystander. The effectiveness of this technique was examined in a manikin-based study. METHODS:Subjects performed CPR on an...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2006.07.025
更新日期：2007-03-01 00:00:00
abstract：AIM:We presented the cut-off value of a diffusion-weighted image (DWI) scoring system to predict poor neurologic outcome using DWI taken 72-96 h after out-of-hospital cardiac arrest (OHCA) patients underwent target temperature management (TTM). METHODS:This was a prospective single-centre observational study, conducte...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2020.08.130
更新日期：2020-12-01 00:00:00
abstract：AIM:Effective assessment of motor skills in large-size classes is a challenge in medical education. This case-study investigates whether a game can be considered a valid tool for the summative assessment of first aid and basic life support skills. METHODS:Using a traditional exam as bench-mark, a board game format was...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2010.12.003
更新日期：2011-04-01 00:00:00
abstract：INTRODUCTION:An impedance threshold device (ITD) has been developed for the treatment of cardiac arrest to augment circulation to the heart and brain during cardiopulmonary resuscitation (CPR). The ITD has ventilation timing lights that flash at 12 min(-1) to discourage excessive ventilation rates. HYPOTHESIS:Implemen...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2005.05.009
更新日期：2005-10-01 00:00:00
abstract：:The frequency spectrum of the ECG in ventricular fibrillation (VF) correlates with myocardial perfusion and might predict defibrillation success defined as return of spontaneous circulation (ROSC). The predictive power increases when more spectral variables are combined, but the complex information can be difficult to...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(00)00266-5
更新日期：2001-03-01 00:00:00
abstract：:Israel is a small country with a population of around 7 million. The sole EMS provider for Israel is Magen David Adom (MDA) (translated as 'Red Shield of David'). MDA also carries out the functions of a National Society (similar to the Red Cross) and provides all the blood and blood product services for the country. N...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2007.07.014
更新日期：2008-01-01 00:00:00
