Abstract：
INTRODUCTION:The outcome after out of hospital cardiac arrest is dismal. Thrombolysis during CPR has been advocated. Our hypothesis was that early administration of bolus thrombolysis could lead to improved survival from out of hospital cardiac arrest. METHODS:A prospective, randomised, double blind placebo controlled trial. All victims of out of hospital cardiac arrest brought to the Emergency Department (ED) by the emergency medical system were eligible for inclusion. All patients received standard advanced cardiac life support, except that the first drug the patient received was either tenecteplase 50 mg or placebo. The primary end point was return of spontaneous circulation (ROSC). RESULTS:Of 35 patients enrolled, 19 received tenecteplase and 16 placebo. The tenecteplase group was younger (63 vs 72 years P = 0.04) and had significantly more ventricular fibrillation as the initial rhythm (63% versus 19%, 44% difference, 95% CI 15-73%). There was no difference in rhythm on arrival at the ED. ROSC occurred in 8 (42%) patients receiving tenecteplase and one (6%) placebo (36% difference, 95% CI 11-61%). Two tenecteplase and one placebo patient survived to leave ED, and one in each group survived to hospital discharge. Autopsy results were available on eight patients, five of whom had a thrombotic cause of death. CONCLUSION:In this pilot study, we found the use of early bolus tenecteplase for OHCA to be feasible, and that it appears to increase the rate of ROSC. Larger studies are required to determine if this translates into a survival benefit. Appropriate patient selection for OHCA studies remains problematic.
journal_name
Resuscitationjournal_title
Resuscitationauthors
Fatovich DM,Dobb GJ,Clugston RAdoi
10.1016/j.resuscitation.2004.01.016keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
309-13issue
3eissn
0300-9572issn
1873-1570pii
S0300957204000334journal_volume
61pub_type
临床试验,杂志文章,随机对照试验相关文献
RESUSCITATION文献大全abstract：AIM:Only up to 20% of patients with out-of-hospital cardiac arrest (OHCA) receive immediate and optimal initial cardiac resuscitation and consequently regain consciousness soon after return of spontaneous circulation (ROSC). In the present study, we compared the outcome of conscious survivors of OHCA presenting with ST...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2018.09.005
更新日期：2018-12-01 00:00:00
abstract：:The demands for an optimal ventilation apparatus are that it can be easily handled, achieves a sufficiently high ventilation volume, and minimizes gastric inflation. Our aim was therefore to carry out a study in a training mannikin to find out whether the Oxylator EM100, compared with the bag, obtains improved ventila...
journal_title：Resuscitation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0300-9572(97)00091-9
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Early defibrillation clearly improves survival from malignant arrhythmia. However, in some cases the cause of death will only be altered from arrhythmic to nonarrhythmic. We evaluated the impact of left ventricular ejection fraction (LVEF) on trend and recovery profile of beat-to-beat cardiac output (CO) and...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2010.06.004
更新日期：2010-09-01 00:00:00
abstract：:ATP-MgCl2 treatment has been found to be a promising intervention in many models of hypoxic/ischemic injury. In this study, the effect of pre-treatment with ATP-MgCl2 on the hemodynamic response to asphyxia in the rat was examined. Rats were anesthetized with halothane and N2O2. A tracheostomy and femoral artery and v...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(93)90089-9
更新日期：1993-04-01 00:00:00
abstract：:Open-chest cardiac massage appears beneficial in improving hemodynamics during resuscitation efforts and in improving resuscitation success. The time between cardiac arrest and the initiation of open-chest cardiac massage is crucial. It would appear that if initiation of open chest cardiac massage is delayed for more ...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(87)90097-9
更新日期：1987-03-01 00:00:00
abstract：:The management of injuries from toxic release (HAZMAT) incidents is unfamiliar to many emergency medical responders owing to the relative rarity of such incidents. However, the risks from toxic release in both industrial and other metropolitan areas are increasing and emergency medical services (EMS) personnel should ...
journal_title：Resuscitation
pub_type： 杂志文章,评审
doi：10.1016/s0300-9572(99)00097-0
更新日期：1999-10-01 00:00:00
abstract：OBJECTIVES:To develop and implement a first responder training programme, assess the feasibility of training lay persons with low literacy in rural Bangladesh and determine the acceptability of the programme in the community. METHODS:A first responder training programme including cardiopulmonary resuscitation (CPR) wa...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2014.04.022
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Hypoxic brain injury is described in up to 40% of survivors after out-of-hospital cardiac arrest (OHCA). Besides cognitive impairments, lack of circulation may also affect exercise capacity. It is not known if exercise capacity of patients with cognitive impairments differs from other OHCA survivors. METHOD...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2017.04.010
更新日期：2017-06-01 00:00:00
abstract：INTRODUCTION:Over five percent of infants born worldwide will need help breathing after birth. Delayed cord clamping (DCC) has become the standard of care for vigorous infants. DCC in non-vigorous infants is uncommon because of logistical difficulties in providing effective resuscitation during DCC. In Baby-Directed Um...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2018.07.020
更新日期：2018-10-01 00:00:00
abstract：AIM OF THE REVIEW:To review the epidemiology, pathophysiology, treatment and prognostication in relation to the post-cardiac arrest syndrome. METHODS:Relevant articles were identified using PubMed, EMBASE and an American Heart Association EndNote master resuscitation reference library, supplemented by hand searches of...
journal_title：Resuscitation
pub_type： 共识发展会议,杂志文章
doi：10.1016/j.resuscitation.2008.09.017
更新日期：2008-12-01 00:00:00
abstract：:The dose of drugs used in pediatric resuscitation is one of the greatest sources of problems. Usually, each drug has a different recommended dosage in mg/kg weight and a different presentation in mg/ml in the ampoule. We suggested a simple solution to simplify drug use in the emergency: we established a common dose of...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(03)00210-7
更新日期：2003-11-01 00:00:00
abstract：:We have reported the finding of numerous spiculed erythrocytes in blood stored for 15-21 days with acid citrate dextrose, drawing attention to the possible decrease of stored red cell deformability because of the decrease of the surface to volume ratio. The presence of anisotropy with crenated spheres, equivalent to t...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(83)90032-1
更新日期：1983-08-01 00:00:00
abstract：:In this retrospective study we report our initial experience with percutaneous venoarterial extracorporeal membrane oxygenation in the emergency treatment of intractable cardiogenic shock or pulseless electrical activity. Between January 1994 and July 1995, percutaneous venoarterial extracorporeal membrane oxygenation...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(96)00989-6
更新日期：1996-11-01 00:00:00
abstract：OBJECTIVES:The present study evaluates a new CPR feedback application for the iPhone (iCPR) designed to improve chest compression performance tested in a cardiac arrest simulation to evaluate performance and acceptance by healthcare professionals and lay people. METHODS:We built an application specifically dedicated t...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2010.11.023
更新日期：2011-04-01 00:00:00
abstract：INTRODUCTION:Electroencephalogram (EEG) background reactivity is a potentially interesting outcome predictor in comatose patients, especially after cardiac arrest, but recent studies report only fair interrater reliability. Furthermore, there are no definite guidelines for its testing. We therefore investigated the EEG...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2015.09.380
更新日期：2015-12-01 00:00:00
abstract：INTRODUCTION:Rapid response systems are commonly employed by hospitals to identify and respond to deteriorating patients outside of the intensive care unit. Controversy exists about the benefits of rapid response systems. AIMS:We aimed to review the current state of the rapid response literature, including evolving as...
journal_title：Resuscitation
pub_type： 杂志文章,评审
doi：10.1016/j.resuscitation.2018.05.013
更新日期：2018-07-01 00:00:00
abstract：:The effects of spontaneous respiration and mechanical ventilation were examined by investigating the interaction between elevated intracranial pressure and alcohol intoxication. Ethanol (200 ml 48%) was infused in 11 young pigs with elevated cerebral pressure during mechanical ventilation (group 1), 7 young pigs with ...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(87)90023-2
更新日期：1987-06-01 00:00:00
abstract：AIM:To analyze the relationship between the depth of the chest compressions and the fluctuation caused in the thoracic impedance (TI) signal in out-of-hospital cardiac arrest (OHCA). The ultimate goal was to evaluate whether it is possible to identify compressions with inadequate depth using information of the TI wavef...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2013.12.035
更新日期：2014-05-01 00:00:00
abstract：:Cardiac arrest causes whole body ischaemic injury and cellular death. Successful cardiopulmonary resuscitation (CPR) can subsequently lead to a global reperfusion phenomenon with a paradoxically increased rate of cellular death. Interventions that decrease the ischaemia-reperfusion injury may be useful in the treatmen...
journal_title：Resuscitation
pub_type： 杂志文章,评审
doi：10.1016/j.resuscitation.2010.06.016
更新日期：2010-11-01 00:00:00
abstract：OBJECTIVES:To validate an existing theoretical model for the mechanics of chest compression (CC) during constant peak force cardiopulmonary resuscitation (CPR) using experimental human and manikin CC data from the literature. Also, to gain insights into the clinical application of force guided CPR. METHODS:The experim...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2012.11.027
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Point-of-care ultrasound has been suggested to improve outcomes from advanced cardiac life support (ACLS), but no large studies have explored how it should be incorporated into ACLS. Our aim was to determine whether cardiac activity on ultrasound during ACLS is associated with improved survival. METHODS:We ...
journal_title：Resuscitation
pub_type： 杂志文章,多中心研究
doi：10.1016/j.resuscitation.2016.09.018
更新日期：2016-12-01 00:00:00
abstract：:The Guidelines 2000 for cardiopulmonary resuscitation recommend shock delivery to victims in ventricular fibrillation within 5 min of call receipt by the Emergency Medical Services. In an effort to achieve this goal, in some parts of the United States, police officers have been trained to use automated external defibr...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/s0300-9572(01)00343-4
更新日期：2001-08-01 00:00:00
abstract：AIM OF THE STUDY:Sternal and rib fractures are frequent complications caused by chest compressions during cardiopulmonary resuscitation (CPR). This study aimed to investigate the potential association of CPR-related thoracic and abdominal injuries and compression depth measured with an accelerometer. METHODS:We analys...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2013.02.015
更新日期：2013-06-01 00:00:00
abstract：AIM:Early invasive strategy, including percutaneous coronary intervention (PCI), may improve survival in out-of-hospital-cardiac-arrest (OHCA) due to coronary artery disease but selection of suitable patients is challenging. Differences and results across gender remain unknown. We aimed to assess the relationship betwe...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2017.02.005
更新日期：2017-05-01 00:00:00
abstract：:This is a report of an 11-year-old boy who had sudden cardiac death after a lightning strike while playing lacrosse at summer camp. The camp staff had performed weekly drills to prepare for various medical emergencies and quickly activated their "Emergency Activation System". The child received immediate cardiopulmona...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2007.02.005
更新日期：2007-09-01 00:00:00
abstract：AIM:To compare the effectiveness of different compression-to-ventilation methods during cardiopulmonary resuscitation (CPR) in patients with cardiac arrest. METHODS:We searched MEDLINE and Cochrane Central Register of Controlled Trials from inception until January 2016. We included experimental, quasi-experimental, an...
journal_title：Resuscitation
pub_type： 杂志文章,评审
doi：10.1016/j.resuscitation.2017.05.032
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:It has been shown that a computer-based audible feedback system can improve acquisition and retention of basic life support (BLS) skills. This system is being developed to work in association with an automated external defibrillator (AED). AIM:To determine if such a feedback system is likely to improve the ...
journal_title：Resuscitation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0300-9572(02)00400-8
更新日期：2003-04-01 00:00:00
abstract：PURPOSE:Incorrect resuscitation after hypovolemic shock is a major contributor to preventable pediatric death. Several studies have demonstrated that small volumes of hypertonic or hypertonic-hyperoncotic saline can be an effective initial resuscitation solution. However, there are no pediatric studies to recommend the...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2012.02.003
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:The outcome among patients who are hospitalised alive after out-of-hospital cardiac arrest is still relatively poor. At present, there are no clear guidelines specifying how they should be treated. The aim of this survey was to describe the outcome for initial survivors of out-of-hospital cardiac arrest when...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/j.resuscitation.2006.08.018
更新日期：2007-04-01 00:00:00
abstract：:Recent reports examining regional blood flow during cardiopulmonary resuscitation (CPR) have been criticized for several reasons: (1) cardiac arrest times of 5 min or less are not reflective of the prehospital setting, (2) anesthetic agents may significantly influence autonomic control of regional blood flow, (3) cani...
journal_title：Resuscitation
pub_type： 杂志文章
doi：10.1016/0300-9572(88)90075-5
更新日期：1988-04-01 00:00:00
