Abstract:
:Using conventional in vitro extracellular field potential recordings we have investigated both short- and long-term synaptic plasticity in the hippocampal CA1 area of mice infected with ME7 scrapie. In agreement with earlier studies, no changes were seen in the properties of the Schäffer collateralevoked field excitatory postsynaptic potential during the early stages of the disease (up to 160 days, post inoculation, d.p.i) after which time the recorded potentials were seen to attenuate. Also, up to this time no changes were seen in either paired-pulse facilitation or post-tetanic potentiation, which are short-term phenomena associated with brief elevations in presynaptic calcium levels. However, there was a significant shift from the ability of slices to maintain long-term potentiation (LTP) from 100 d.p.i. onwards. In all of these experiments short-term potentiation (STP) was preserved, suggesting that from the time that abnormal PrP becomes detectable, or perhaps even earlier, the mechanisms responsible for stabilizing the maintenance phase of LTP are impaired. This result is discussed in terms of the relationship between STP and LTP and how this might be compromised by the conversion of cellular prion protein (PrPC) to the scrapie, protease resistant form of PrP (PrPSc).
journal_name
Neurobiol Disjournal_title
Neurobiology of diseaseauthors
Johnston AR,Fraser JR,Jeffrey M,MacLeod Ndoi
10.1006/nbdi.1998.0194subject
Has Abstractpub_date
1998-09-01 00:00:00pages
188-95issue
3eissn
0969-9961issn
1095-953Xpii
S0969-9961(98)90194-2journal_volume
5pub_type
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journal_title:Neurobiology of disease
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