Abstract:
:Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and ultimately fatal neurodegenerative disease, caused by the loss of motor neurons in the brain and spinal cord. Although 10% of ALS cases are familial (FALS), the majority are sporadic (SALS) and probably associated to a multifactorial etiology. Currently there is no cure or prevention for ALS. A prerequisite to formulating therapeutic strategies is gaining understanding of its etio-pathogenic mechanisms. In this study we analyzed whole-genome expression profiles of 41 motor cortex samples of control (10) and sporadic ALS (31) patients. Unsupervised hierarchical clustering was able to separate control from SALS patients. In addition, SALS patients were subdivided in two different groups that were associated to different deregulated pathways and genes, some of which were previously associated to familiar ALS. These experiments are the first to highlight the genomic heterogeneity of sporadic ALS and reveal new clues to its pathogenesis and potential therapeutic targets.
journal_name
Neurobiol Disjournal_title
Neurobiology of diseaseauthors
Aronica E,Baas F,Iyer A,ten Asbroek AL,Morello G,Cavallaro Sdoi
10.1016/j.nbd.2014.12.002subject
Has Abstractpub_date
2015-02-01 00:00:00pages
359-76eissn
0969-9961issn
1095-953Xpii
S0969-9961(14)00373-8journal_volume
74pub_type
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