Abstract：
:Tardive Dyskinesia (TD) is a hyperkinetic movement disorder caused by chronic treatment of psychiatric patients with dopamine (DA) receptor blocking drugs (Stacy & Jankovic 1991). Although TD is one of the most important and frequently encountered iatrogenic disorders in clinical medicine, its pathophysiology is poorly understood. We have observed a hyperkinetic movement disorder in rats experimentally infected with a neurotropic RNA virus, Borna disease virus, that may provide important insights into the pathophysiology of TD. Like TD patients, infected rats show prominent orofacial dyskinesias. In keeping with the dopamine (Goetz & Klawans 1982) and anatomic (Fibiger & Lloyd 1984) hypotheses of TD, the Borna disease rat model shows enhanced behavioural sensitivity to DA agonists and selective striatal cell damage. There is also evidence of DA deafferentation and heterogeneous reduction of D2 binding in the caudate-putamen, particularly from sites implicated in oral behaviour. These observations on a virus-induced movement disorder offer novel approaches to TD pathogenesis.
journal_name
Neurobiol Disjournal_title
Neurobiology of diseaseauthors
Solbrig MV,Koob GF,Fallon JH,Lipkin WIdoi
10.1006/nbdi.1994.0014subject
Has Abstractpub_date
1994-12-01 00:00:00pages
111-9issue
3eissn
0969-9961issn
1095-953Xpii
S0969-9961(84)70014-3journal_volume
1pub_type
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