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Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia.

Abstract：

:We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (L-DOPA)-induced dyskinesia and Parkinson disease (PD). 6-Hydroxydopamine (6-OHDA)-lesioned rats were treated with L-DOPA or physiological saline for 22 days and repeatedly tested for antiakinetic response to L-DOPA and the development of abnormal involuntary movements (AIMs). In a comparison of rats that developed a dyskinetic motor response to rats that did not, we found striking differences in gene expression patterns. In rats that developed dyskinesia, GABA neurons had an increased transcriptional activity, and genes involved in Ca2+ homeostasis, in Ca2+ -dependent signaling, and in structural and synaptic plasticity were upregulated. The gene expression patterns implied that the dyskinetic striatum had increased transcriptional, as well as synaptic activity, and decreased capacity for energy production. Some basic maintenance chores such as ribosome protein biosynthesis were downregulated, possibly a response to expended ATP levels.

journal_name

Neurobiol Dis

journal_title

Neurobiology of disease

authors

Konradi C,Westin JE,Carta M,Eaton ME,Kuter K,Dekundy A,Lundblad M,Cenci MA

doi

10.1016/j.nbd.2004.07.005

keywords:

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

219-36

issue

2

eissn

0969-9961

issn

1095-953X

pii

S0969-9961(04)00159-7

journal_volume

17

pub_type

杂志文章

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