Abstract：
:Neurodegenerative diseases impose a burden on society, yet for the most part, the mechanisms underlying neuronal dysfunction and death in these disorders remain unclear despite the identification of relevant disease genes. Given the molecular conservation in neuronal signaling pathways across vertebrate and invertebrate species, many researchers have turned to the nematode Caenorhabditis elegans to identify the mechanisms underlying neurodegenerative disease pathology. C. elegans can be engineered to express human proteins associated with neurodegeneration; additionally, the function of C. elegans orthologs of human neurodegenerative disease genes can be dissected. Herein, we examine major C. elegans neurodegeneration models that recapitulate many aspects of human neurodegenerative disease and we survey the screens that have identified modifier genes. This review highlights how the C. elegans community has used this versatile organism to model several aspects of human neurodegeneration and how these studies have contributed to our understanding of human disease.
journal_name
Neurobiol Disjournal_title
Neurobiology of diseaseauthors
Dimitriadi M,Hart ACdoi
10.1016/j.nbd.2010.05.012subject
Has Abstractpub_date
2010-10-01 00:00:00pages
4-11issue
1eissn
0969-9961issn
1095-953Xpii
S0969-9961(10)00163-4journal_volume
40pub_type
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