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Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia.

Abstract：

:Markers of the kynurenine pathway were studied in postmortem frontal cortex obtained from individuals with schizophrenia and controls. Quantitative endpoint RT-PCR was used to measure mRNA transcripts. Of the two enzymes capable of catalyzing the first step in the pathway, tryptophan 2,3-dioxygenase (TDO2) and indoleamine dioxygenase (IDO), the concentration of mRNA for TDO2 was found to be elevated 1.6-fold in the schizophrenia group (P = 0.03), whereas the concentration of the mRNA for IDO was not significantly different between the schizophrenia and control groups. Immunohistochemistry showed an increased density of TDO2-immunopositive astroglial cells in the white matter of patients with schizophrenia (P = 0.04). Neurons and vessels were also immunopositive for TDO2, but there were no significant differences in labeling of these structures between the two groups. These results add to the evidence that kynurenine pathway changes might be involved in the pathogenesis of schizophrenia and the schizophrenia-like psychoses of other disorders.

journal_name

Neurobiol Dis

journal_title

Neurobiology of disease

authors

Miller CL,Llenos IC,Dulay JR,Barillo MM,Yolken RH,Weis S

doi

10.1016/j.nbd.2003.12.015

keywords:

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

618-29

issue

3

eissn

0969-9961

issn

1095-953X

pii

S0969996104000026

journal_volume

15

pub_type

杂志文章

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