Abstract：
:Neuroprotective functions of erythropoietin (Epo) are thought to involve a heteroreceptor composed of both Epo receptor (Epo-R) and common beta chain (betac). Here, we measured the response of hippocampal Epo system components (Epo, Epo-R and betac) during neurodegenerative processes following pilocarpine-induced status epilepticus (SE), and examined whether recombinant human Epo (rHuEpo) could support neuronal survival. We evidence that Epo is induced in astroglia following SE, in particular within areas displaying delayed neuronal death. In addition, we demonstrate for the first time that rHuEpo reduces considerably hippocampal neurodegeneration following SE. rHuEpo may thus supplement astroglial induction of Epo to promote enhanced hippocampal neuronal survival following SE. We also show that Epo-R is expressed by neurons and astrocytes mainly, while betac is barely detectable in basal conditions and induced in reactive microglia exclusively following SE. Altogether, our results suggest that Epo/rHuEpo exerts neuroprotection, through Epo-R signaling and independently of betac, and, therefore, may be anti-epileptogenic.
journal_name
Neurobiol Disjournal_title
Neurobiology of diseaseauthors
Nadam J,Navarro F,Sanchez P,Moulin C,Georges B,Laglaine A,Pequignot JM,Morales A,Ryvlin P,Bezin Ldoi
10.1016/j.nbd.2006.10.009subject
Has Abstractpub_date
2007-02-01 00:00:00pages
412-26issue
2eissn
0969-9961issn
1095-953Xpii
S0969-9961(06)00259-2journal_volume
25pub_type
杂志文章abstract：:Major depressive disorder (MDD) is one of the most prevalent major psychiatric disorders with a lifetime prevalence of 17%. Recent evidence suggests MDD is not only a brain dysfunction, but a systemic disease affecting the whole body. Central and peripheral inflammatory changes seem to be a centerpiece of MDD patholog...
journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
pub_type： 杂志文章,评审
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journal_title：Neurobiology of disease
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doi：10.1006/nbdi.2000.0305
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journal_title：Neurobiology of disease
pub_type： 杂志文章,评审
doi：10.1016/j.nbd.2018.10.008
更新日期：2019-03-01 00:00:00
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doi：10.1016/j.nbd.2010.09.016
更新日期：2011-02-01 00:00:00
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journal_title：Neurobiology of disease
pub_type： 杂志文章
doi：10.1016/j.nbd.2018.08.024
更新日期：2018-12-01 00:00:00
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journal_title：Neurobiology of disease
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doi：10.1016/j.nbd.2010.11.002
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journal_title：Neurobiology of disease
pub_type： 杂志文章
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journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
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journal_title：Neurobiology of disease
pub_type： 杂志文章
doi：10.1016/j.nbd.2007.03.014
更新日期：2007-08-01 00:00:00
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journal_title：Neurobiology of disease
pub_type： 杂志文章
doi：10.1016/j.nbd.2016.02.003
更新日期：2016-05-01 00:00:00
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journal_title：Neurobiology of disease
pub_type： 杂志文章
doi：10.1016/j.nbd.2003.12.015
更新日期：2004-04-01 00:00:00
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journal_title：Neurobiology of disease
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doi：10.1016/j.nbd.2020.105152
更新日期：2021-01-01 00:00:00
abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized behaviorally by chorea, incoordination, and shortened lifespan and neuropathologically by huntingtin inclusions and neuronal degeneration. In order to facilitate studies of pathogenesis and therapeutics, we have generated a new...
journal_title：Neurobiology of disease
pub_type： 杂志文章
doi：10.1016/j.nbd.2005.07.014
更新日期：2006-02-01 00:00:00
abstract：:The rapidly emerging science of epigenetics and epigenomic medicine promises to reveal novel insights into the susceptibility to and the onset and progression of epileptic disorders. Epigenetic regulatory mechanisms are now implicated in orchestrating aspects of neural development (e.g., cell fate specification and ma...
journal_title：Neurobiology of disease
pub_type： 杂志文章,评审
doi：10.1016/j.nbd.2010.02.005
更新日期：2010-07-01 00:00:00
