Alpha-synuclein and transgenic mouse models.

Abstract:

:Identified as the cause of some familial forms of Parkinson disease (PD) and as one of the major component of Lewy bodies, alpha-synuclein (alpha-syn) became the molecular hallmark of several neurodegenerative conditions now designated as synucleinopathies. Transgenic models have been generated to elucidate its physiological and pathologic roles. Although none of the lines created display dopaminergic neuronal death in the substantia nigra, the models recapitulate some features of synucleinopathies and are useful to study the potential pathogenic role of alpha-synuclein and its molecular partners. This review describes the different alpha-synuclein transgenic models, their clinical relevance to synucleinopathies, and their further utilization to understand the disease process.

journal_name

Neurobiol Dis

journal_title

Neurobiology of disease

authors

Fernagut PO,Chesselet MF

doi

10.1016/j.nbd.2004.07.001

keywords:

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

123-30

issue

2

eissn

0969-9961

issn

1095-953X

pii

S0969-9961(04)00150-0

journal_volume

17

pub_type

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