当前位置： SCI文献检索 > NEUROBIOLOGY OF DISEASE期刊下所有文献 > Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability.

Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability.

Abstract：

:Increasing evidence has linked inflammatory processes to neurodegenerative disorders, including Alzheimer's and Parkinson's disease (PD). Tumor necrosis factor alpha (TNF-alpha) is a key inflammatory cytokine and several studies linked increased TNF-alpha to dopaminergic cell death in PD. The TNF-alpha promoter sequence contains several CpG dinucleotides located within or next to transcription factor binding sites. To test the hypothesis whether the methylation state of the TNF-alpha promoter contributes to increased expression of TNF-alpha in PD we compared DNA from different brain regions (substantia nigra pars compacta (SNpc) and cortex) of PD patients and neurologically healthy, age and sex matched controls by bisulfite sequencing of the TNF-alpha promoter region. The TNF-alpha promoter DNA from SNpc was significantly less methylated in comparison to DNA from cortex; however both in PD patients and controls. Although there was a tendency for hypomethylation in PD, our analysis of the 10 CpGs in the TNF-alpha core promoter region (-258 to -35 relative to the TSS) revealed no particular pattern in PD patients compared to control and identified no particular hypomethylated position in cortex or SNpc DNA. Electrophoretic mobility shift and luciferase reporter assays showed that methylation of specific solitary CpG in the TNF-alpha promoter resulted in reduced binding of the transcription factors AP-2 and Sp1, respectively, and suppressed TNF-alpha promoter activity. The brain region specific methylation state of solitary CpG in the TNF-alpha promoter thus determines transcription factor binding efficacy and TNF-alpha expression. A lesser degree of methylation of the TNF-alpha promoter in SNpc cells could underlie the increased susceptibility of dopaminergic neurons to TNF-alpha mediated inflammatory reactions.

journal_name

Neurobiol Dis

journal_title

Neurobiology of disease

authors

Pieper HC,Evert BO,Kaut O,Riederer PF,Waha A,Wüllner U

doi

10.1016/j.nbd.2008.09.010

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

521-7

issue

3

eissn

0969-9961

issn

1095-953X

pii

S0969-9961(08)00218-0

journal_volume

32

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF DISEASE文献大全
  • Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease.

    abstract：:Chronic microglial activation has been linked to the progressive degeneration of the nigrostriatal dopaminergic neurons evidenced in Parkinson's disease (PD) pathogenesis. The exact etiology of PD remains poorly understood. Although both oxidative stress and neuroinflammation are identified as co-contributors in PD pa...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2016.04.008

    authors： Gordon R,Singh N,Lawana V,Ghosh A,Harischandra DS,Jin H,Hogan C,Sarkar S,Rokad D,Panicker N,Anantharam V,Kanthasamy AG,Kanthasamy A

    更新日期：2016-09-01 00:00:00

  • Adeno-associated viral vector-mediated gene transfer of brain-derived neurotrophic factor reverses atrophy of rubrospinal neurons following both acute and chronic spinal cord injury.

    abstract：:Rubrospinal neurons (RSNs) undergo marked atrophy after cervical axotomy. This progressive atrophy may impair the regenerative capacity of RSNs in response to repair strategies that are targeted to promote rubrospinal tract regeneration. Here, we investigated whether we could achieve long-term rescue of RSNs from lesi...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2003.11.018

    authors： Ruitenberg MJ,Blits B,Dijkhuizen PA,te Beek ET,Bakker A,van Heerikhuize JJ,Pool CW,Hermens WT,Boer GJ,Verhaagen J

    更新日期：2004-03-01 00:00:00

  • Neutral sphingomyelinase activation in endothelial and glial cell death induced by amyloid beta-peptide.

    abstract：:We have explored the molecular mechanism underlying amyloid beta-peptide (Abeta)-mediated cytotoxicity in vitro. Exposure of murine cerebral endothelial cells (CECs) or C6 glioma cells to Abeta25-35 resulted in dose-dependent cell death. Ceramide is a pro-apoptotic lipid mediator. Forced elevation of cellular ceramide...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2004.06.001

    authors： Yang DI,Yeh CH,Chen S,Xu J,Hsu CY

    更新日期：2004-10-01 00:00:00

  • Worsening of Huntington disease phenotype in CB1 receptor knockout mice.

    abstract：:Huntington's disease (HD) is a progressive neurodegenerative genetic disorder which leads to motor, cognitive and psychiatric disturbances. The primary neuropathological hallmark is atrophy of the striatum. Cannabinoid CB1 receptors (CB1Rs) are particularly enriched in the striatum and previous works indicate their ea...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2011.03.006

    authors： Mievis S,Blum D,Ledent C

    更新日期：2011-06-01 00:00:00

  • Functional MAPT haplotypes: bridging the gap between genotype and neuropathology.

    abstract：:The microtubule-associated protein tau (MAPT) locus has long been associated with sporadic neurodegenerative disease, notably progressive supranuclear palsy and corticobasal degeneration, and more recently with Alzheimer's disease and Parkinson's disease. However, the functional biological mechanisms behind the geneti...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章,评审

    doi：10.1016/j.nbd.2007.04.006

    authors： Caffrey TM,Wade-Martins R

    更新日期：2007-07-01 00:00:00

  • Mechanisms leading to disseminated apoptosis following NMDA receptor blockade in the developing rat brain.

    abstract：:The developing rodent brain is vulnerable to pharmacological blockade of N-methyl-d-aspartate (NMDA) receptors which can lead to severe and disseminated apoptotic neurodegeneration. Here, we show that systemic administration of the NMDA receptor antagonist MK801 to 7-day-old rats leads to impaired activity of extracel...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2004.03.013

    authors： Hansen HH,Briem T,Dzietko M,Sifringer M,Voss A,Rzeski W,Zdzisinska B,Thor F,Heumann R,Stepulak A,Bittigau P,Ikonomidou C

    更新日期：2004-07-01 00:00:00

  • Frataxin shows developmentally regulated tissue-specific expression in the mouse embryo.

    abstract：:Friedreich ataxia (FRDA) is an autosomal recessive degenerative disease caused either by an intronic GAA triplet repeat expansion that suppresses the expression of the frataxin gene on chromosome 9q13, or, rarely, by point mutations in the frataxin gene. We investigated the expression of the mouse frataxin homologue d...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1006/nbdi.1997.0139

    authors： Jiralerspong S,Liu Y,Montermini L,Stifani S,Pandolfo M

    更新日期：1997-01-01 00:00:00

  • Cytokine profiling in the prefrontal cortex of Parkinson's Disease and Multiple System Atrophy patients.

    abstract：:Parkinson's Disease (PD) and Multiple System Atrophy (MSA) are neurodegenerative diseases characterized neuropathologically by alpha-synuclein accumulation in brain cells. This accumulation is hypothesized to contribute to constitutive neuroinflammation, and to participate in the neurodegeneration. Cytokines, which ar...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2017.07.014

    authors： Rydbirk R,Elfving B,Andersen MD,Langbøl MA,Folke J,Winge K,Pakkenberg B,Brudek T,Aznar S

    更新日期：2017-10-01 00:00:00

  • Alzheimer's brains show inter-related changes in RNA and lipid metabolism.

    abstract：:Alzheimer's disease (AD) involves changes in both lipid and RNA metabolism, but it remained unknown if these differences associate with AD's cognition and/or post-mortem neuropathology indices. Here, we report RNA-sequencing evidence of inter-related associations between lipid processing, cognition level, and AD neuro...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2017.06.008

    authors： Barbash S,Garfinkel BP,Maoz R,Simchovitz A,Nadorp B,Guffanti A,Bennett ER,Nadeau C,Türk A,Paul L,Reda T,Li Y,Buchman AS,Greenberg DS,Seitz A,Bennett DA,Giavalisco P,Soreq H

    更新日期：2017-10-01 00:00:00

  • Biology of A beta amyloid in Alzheimer's disease.

    abstract：:The genetic associations with the pathological features of AD are diverse: A rapidly growing number of mutations in presenilin 1 and 2 on chromosomes 14 and 1, respectively, are found in many early-onset FAD patients (Lendon et al., 1997). In addition, beta PP mutations are found in a small percentage of early-onset F...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章,评审

    doi：10.1006/nbdi.1997.0147

    authors： Wisniewski T,Ghiso J,Frangione B

    更新日期：1997-01-01 00:00:00

  • Triptolide protects dopaminergic neurons from inflammation-mediated damage induced by lipopolysaccharide intranigral injection.

    abstract：:Converging lines of evidence suggest that neuroinflammatory processes may account for the progressive death of dopaminergic neurons in Parkinson's disease (PD). Therefore, anti-inflammatory strategies have attracted much interest for their potential to prevent further deterioration of PD. Our previous study showed tha...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2004.12.005

    authors： Zhou HF,Liu XY,Niu DB,Li FQ,He QH,Wang XM

    更新日期：2005-04-01 00:00:00

  • IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors.

    abstract：:Cytokine-dependent mechanisms in the CNS have been implicated in the pathogenesis of depression. Interleukin-6 is upregulated in depressed patients and dowregulated by antidepressants. It is, however, unknown whether IL-6 is involved in the pathogenesis of depression. We subjected IL-6-deficient mice (IL-6(-/-)) to de...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2006.05.001

    authors： Chourbaji S,Urani A,Inta I,Sanchis-Segura C,Brandwein C,Zink M,Schwaninger M,Gass P

    更新日期：2006-09-01 00:00:00

  • Cerebrovascular pathology during the progression of experimental Alzheimer's disease.

    abstract：:Clinical and experimental evidence point to a possible role of cerebrovascular dysfunction in Alzheimer's disease (AD). The 5xFAD mouse model of AD expresses human amyloid precursor protein and presenilin genes with mutations found in AD patients. It remains unknown whether amyloid deposition driven by these mutations...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2016.01.001

    authors： Giannoni P,Arango-Lievano M,Neves ID,Rousset MC,Baranger K,Rivera S,Jeanneteau F,Claeysen S,Marchi N

    更新日期：2016-04-01 00:00:00

  • Hereditary sensory neuropathy type 1-associated deoxysphingolipids cause neurotoxicity, acute calcium handling abnormalities and mitochondrial dysfunction in vitro.

    abstract：:Hereditary sensory neuropathy type 1 (HSN-1) is a peripheral neuropathy most frequently caused by mutations in the SPTLC1 or SPTLC2 genes, which code for two subunits of the enzyme serine palmitoyltransferase (SPT). SPT catalyzes the first step of de novo sphingolipid synthesis. Mutations in SPT result in a change in ...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2018.05.008

    authors： Wilson ER,Kugathasan U,Abramov AY,Clark AJ,Bennett DLH,Reilly MM,Greensmith L,Kalmar B

    更新日期：2018-09-01 00:00:00

  • A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy.

    abstract：:Mutations in the DNA-binding domain of EGR2 are associated with severe autosomal dominant forms of peripheral neuropathy. In this study, we show that one such Egr2 mutant (S382R, D383Y), when expressed in Schwann cells in vitro, is not transcriptionally inactive but retains residual wild-type Egr2 functions, including...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2006.06.006

    authors： Arthur-Farraj P,Mirsky R,Parkinson DB,Jessen KR

    更新日期：2006-10-01 00:00:00

  • Changes in cytoskeletal gene expression linked to MPTP-treatment in Mice.

    abstract：:Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra and a marked reduction of dopamine (DA) levels in the striatum. Binding to its specific receptors, DA switches on a complex program of intracellular signaling that regulates gene ex...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2005.05.014

    authors： Cuadrado-Tejedor M,Sesma MT,Giménez-Amaya JM,Ortiz L

    更新日期：2005-12-01 00:00:00

  • Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex.

    abstract：BACKGROUND:Epidemiological studies suggest that the risk of neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia is increased by prenatal exposure to viral or bacterial infection during pregnancy. It is still unclear how activation of the maternal immune response interacts with underlyi...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2019.01.025

    authors： Amodeo DA,Lai CY,Hassan O,Mukamel EA,Behrens MM,Powell SB

    更新日期：2019-05-01 00:00:00

  • Ethanol-induced death of postnatal hippocampal neurons.

    abstract：:Fetal alcohol exposure causes severe neuropsychiatric problems, but mechanisms of the ethanol-associated changes in central nervous system development are unclear. In vivo, ethanol's interaction with N-methyl-D-aspartate (NMDA) and gamma-aminobutyric acid type A (GABA(A)) receptors may cause increased apoptosis in the...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1006/nbdi.2002.0523

    authors： Moulder KL,Fu T,Melbostad H,Cormier RJ,Isenberg KE,Zorumski CF,Mennerick S

    更新日期：2002-08-01 00:00:00

  • Marked influence of the route of infection on prion strain apparent phenotype in a scrapie transgenic mouse model.

    abstract：:Prion strains yield specific neuropathological features including spongiform degeneration and deposition patterns of pathological prion protein. Their invariant regional distribution, following variations in the infection route, has led to the proposal that prions replicate preferentially in defined neuro-anatomical a...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2010.09.010

    authors： Langevin C,Andréoletti O,Le Dur A,Laude H,Béringue V

    更新日期：2011-01-01 00:00:00

  • Abnormal latent inhibition and impulsivity in coloboma mice, a model of ADHD.

    abstract：:Attention deficit hyperactivity disorder (ADHD) is characterized by hyperactivity, inattention, and impulsivity. The coloboma mouse model of ADHD exhibits profound hyperactivity. To determine whether coloboma mice exhibit other signs of ADHD, we assessed latent inhibition as a test of attention, and impulsivity in a d...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2006.09.009

    authors： Bruno KJ,Freet CS,Twining RC,Egami K,Grigson PS,Hess EJ

    更新日期：2007-01-01 00:00:00

  • NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease.

    abstract：:Huntington disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the HTT gene, remains without a treatment to modify the course of the illness. Lithium, a drug widely used for the treatment of bipolar disorder, has been shown to exert neuroprotective effects in a number of models of neurologic...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2012.06.026

    authors： Pouladi MA,Brillaud E,Xie Y,Conforti P,Graham RK,Ehrnhoefer DE,Franciosi S,Zhang W,Poucheret P,Compte E,Maurel JC,Zuccato C,Cattaneo E,Néri C,Hayden MR

    更新日期：2012-12-01 00:00:00

  • Insulin-like growth factor-I in muscle metabolism and myotherapies.

    abstract：:The critical anabolic and trophic role of signaling by insulin-like growth factors (IGF) I and II via the type-I IGF receptor (IGF-IR) is reviewed throughout the life of skeletal myocytes. The proliferative effects of IGF-IR stimulation, both during embryogenesis and during satellite cell proliferation following dener...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章,评审

    doi：10.1006/nbdi.2001.0416

    authors： Singleton JR,Feldman EL

    更新日期：2001-08-01 00:00:00

  • Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.

    abstract：:Aggregation of α-synuclein (α-syn) is neuropathologically and genetically linked to Parkinson's disease (PD). Since stereotypic cell-to-cell spreading of α-syn pathology is believed to contribute to disease progression, immunotherapy with antibodies directed against α-syn is considered a promising therapeutic approach...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2018.10.016

    authors： Weihofen A,Liu Y,Arndt JW,Huy C,Quan C,Smith BA,Baeriswyl JL,Cavegn N,Senn L,Su L,Marsh G,Auluck PK,Montrasio F,Nitsch RM,Hirst WD,Cedarbaum JM,Pepinsky RB,Grimm J,Weinreb PH

    更新日期：2019-04-01 00:00:00

  • The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress.

    abstract：:GPNMB is a glycoprotein observed upon tissue damage and inflammation and is associated with astrocytes, microglia, and macrophages. Gene variations in GPNMB are linked with Parkinson's disease (PD) risk, and changes in protein levels of GPNMB have been found in lysosomal storage disorders, including Gaucher's disease ...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2018.08.013

    authors： Moloney EB,Moskites A,Ferrari EJ,Isacson O,Hallett PJ

    更新日期：2018-12-01 00:00:00

  • A prion protein fragment primes type 1 astrocytes to proliferation signals from microglia.

    abstract：:Giliosis is a hallmark of prion disease. A neurotoxic prion peptide (PrP106-126) induces astrocyte proliferation in the presence of microglia. This peptide also directly enhances microglial proliferation in culture. We have investigated this further to understand the method by which factors released by microglia and P...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1006/nbdi.1998.0169

    authors： Brown DR,Schmidt B,Kretzschmar HA

    更新日期：1998-04-01 00:00:00

  • Dehydroepiandrosterone reduces expression and activity of BACE in NT2 neurons exposed to oxidative stress.

    abstract：:Recently, we showed that oxidative stress activates the expression and activity of the beta-site AbetaPP-cleaving enzyme (BACE), an aspartyl protease responsible for the beta-secretase cleavage of AbetaPP. The identification of compounds able to prevent the induction of this event is an important goal of therapeutic s...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/s0969-9961(03)00131-1

    authors： Tamagno E,Guglielmotto M,Bardini P,Santoro G,Davit A,Di Simone D,Danni O,Tabaton M

    更新日期：2003-11-01 00:00:00

  • Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy.

    abstract：:Multiple system atrophy is a progressive, neurodegenerative disease characterized by parkinsonism, ataxia, autonomic dysfunction, and accumulation of α-synuclein in oligodendrocytes. To understand how α-synuclein aggregates impact oligodendroglial homeostasis, we investigated an oligodendroglial cell model of α-synucl...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2013.12.002

    authors： Kragh CL,Gysbers AM,Rockenstein E,Murphy K,Halliday GM,Masliah E,Jensen PH

    更新日期：2014-03-01 00:00:00

  • Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1.

    abstract：:To study the role of Abeta amyloid deposits in the generation of cytoskeletal lesions, we have generated a transgenic mouse line coexpressing in the same neurons a wild-type human tau isoform (0N3R), a mutant form of APP (751SL) and a mutant form of PS1 (M146L). These mice developed early cerebral extracellular deposi...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2003.09.007

    authors： Boutajangout A,Authelet M,Blanchard V,Touchet N,Tremp G,Pradier L,Brion JP

    更新日期：2004-02-01 00:00:00

  • The IL-1beta system in epilepsy-associated malformations of cortical development.

    abstract：:Focal cortical dysplasia (FCD) and glioneuronal tumors (GNT) are recognized causes of chronic intractable epilepsy. The cellular mechanism(s) underlying their epileptogenicity remain largely unknown. Compelling evidence in experimental models of seizures indicates an important role of interleukin (IL)-1beta in the mec...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2006.06.003

    authors： Ravizza T,Boer K,Redeker S,Spliet WG,van Rijen PC,Troost D,Vezzani A,Aronica E

    更新日期：2006-10-01 00:00:00

  • Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α.

    abstract：:Pathological oxygen deprivation inhibits prolyl hydroxylase (PHD) activity and stimulates a protective cellular oxygen-sensing response in part through the stabilization and activation of the Hypoxia Inducible Factor (HIF) 1α transcription factor. The present investigation tested the therapeutic potential of enhanced ...

    journal_title：Neurobiology of disease

    pub_type： 杂志文章

    doi：10.1016/j.nbd.2011.10.020

    authors： Ogle ME,Gu X,Espinera AR,Wei L

    更新日期：2012-02-01 00:00:00