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How the shapes of seeds can influence pathology.

Abstract：

:It is widely accepted that the loss of function of different cellular proteins following their aggregation into highly stable aggregates or the gain of pathologic function of the resulting macromolecular assemblies or both processes are tightly associated to distinct debilitating neurodegenerative diseases such as Alzheimer's, Parkinson's, Creutzfeldt-Jacob, Amyotrophic Lateral Sclerosis and Huntington's diseases. How the aggregation of one given protein leads to distinct diseases is unclear. Here, a structural-molecular explanation based on the ability of proteins such as α-synuclein or tau to form assemblies that differ by their intrinsic architecture, stability, seeding capacity, and surfaces is proposed to account for distinct synucleinopathies and tauopathies. The shape and surfaces of the seeds is proposed to define at the same time their seeding capacity, interactome and tropism for defined neuronal cells within the central nervous system.

journal_name

Neurobiol Dis

journal_title

Neurobiology of disease

authors

Melki R

doi

10.1016/j.nbd.2017.03.011

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

201-208

issue

Pt B

eissn

0969-9961

issn

1095-953X

pii

S0969-9961(17)30060-8

journal_volume

109

pub_type

杂志文章

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