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Expression of the methyl-CpG-binding protein MeCP2 in rat brain. An ontogenetic study.

Abstract：

:Rett syndrome (RS) is caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2) and is characterized by arrested postnatal neurodevelopment. We followed the expression of MeCP2 protein in various brain structures of normal rat from birth to 2 years of age. By measuring the amount of protein using the Western blot technique, or by determining the percentage of immunoreactive cells, significant heterogeneity in MeCP2 distribution among various brain areas was observed. Highest expression was found in olfactory bulb and in frontal cortex. In contrast, little expression was detected in caudate-putamen, septum and hippocampus. Except in the olfactive nuclei, very few cells showed detectable MeCP2 protein at birth. The number increased during the first week of age, especially in cortex and nucleus accumbens. Rather than playing a global role in gene transcription, the heterogeneous distribution of MeCP2 transcription factor favors the idea that it has a specialized function in neurons.

journal_name

Neurobiol Dis

journal_title

Neurobiology of disease

authors

Cassel S,Revel MO,Kelche C,Zwiller J

doi

10.1016/j.nbd.2003.10.011

keywords:

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

206-11

issue

2

eissn

0969-9961

issn

1095-953X

pii

S096999610300216X

journal_volume

15

pub_type

杂志文章

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