Abstract:
:The brain of Alzheimer's disease patients shows abundant dystrophic neurites in close proximity to fibrillar beta-amyloid (A beta) plaques, and activated glial cells. We evaluated the influence of pro-inflammatory molecules (LPS + IFN-gamma) on A beta(1-42) neurotoxicity. 2 microM A beta(1-42) induced apoptosis of hippocampal cells and LPS + IFN-gamma reduced the apoptosis induced by A beta. However, LPS + IFN-gamma prevented apoptosis only in hippocampal cultures containing astrocytes. Also, LPS + IFN-gamma induced the secretion of TGF beta, a cytokine having neuroprotective effects, only in hippocampal cultures that contained astrocytes. Astrocytes had a regulatory effect over microglial and neuronal responses to A beta. The results suggest that LPS + IFN-gamma, traditionally considered as pro-apoptotic, reduced apoptosis induced by A beta through the activation of neuroprotective mechanisms mediated by astrocytes. We propose that astrocytes are pivotal in the modulation of inflammation of the CNS. The impairment of the regulatory functions performed by activated astrocytes could represent an important pathogenic mechanism for neurodegenerative diseases.
journal_name
Neurobiol Disjournal_title
Neurobiology of diseaseauthors
Ramírez G,Toro R,Döbeli H,von Bernhardi Rdoi
10.1016/j.nbd.2005.01.007keywords:
subject
Has Abstractpub_date
2005-06-01 00:00:00pages
243-54issue
1-2eissn
0969-9961issn
1095-953Xpii
S0969-9961(05)00006-9journal_volume
19pub_type
杂志文章abstract::The worldwide proliferation of mobile phones raises the question of the effects of 900-MHz electromagnetic fields (EMF) on the brain. Using a head-only exposure device in the rat, we showed that a 15-min exposure to 900-MHz pulsed microwaves at a high brain-averaged power of 6 W/kg induced a strong glial reaction in t...
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journal_title:Neurobiology of disease
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journal_title:Neurobiology of disease
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journal_title:Neurobiology of disease
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doi:10.1016/j.nbd.2008.09.010
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journal_title:Neurobiology of disease
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journal_title:Neurobiology of disease
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更新日期:1997-01-01 00:00:00
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journal_title:Neurobiology of disease
pub_type: 杂志文章
doi:10.1006/nbdi.2000.0335
更新日期:2001-02-01 00:00:00
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journal_title:Neurobiology of disease
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doi:10.1016/j.nbd.2007.06.015
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journal_title:Neurobiology of disease
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journal_title:Neurobiology of disease
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journal_title:Neurobiology of disease
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journal_title:Neurobiology of disease
pub_type: 杂志文章,评审
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更新日期:2004-11-01 00:00:00
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journal_title:Neurobiology of disease
pub_type: 杂志文章
doi:10.1006/nbdi.1998.0225
更新日期:1999-02-01 00:00:00
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journal_title:Neurobiology of disease
pub_type: 杂志文章
doi:10.1016/j.nbd.2012.03.008
更新日期:2012-06-01 00:00:00
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journal_title:Neurobiology of disease
pub_type: 杂志文章
doi:10.1016/j.nbd.2006.07.013
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journal_title:Neurobiology of disease
pub_type: 杂志文章
doi:10.1016/j.nbd.2013.12.008
更新日期:2014-04-01 00:00:00
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journal_title:Neurobiology of disease
pub_type: 杂志文章
doi:10.1016/j.nbd.2009.02.011
更新日期:2009-05-01 00:00:00
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journal_title:Neurobiology of disease
pub_type: 杂志文章
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