Abstract：
BACKGROUND:An open-label, randomised, multicentre study was carried out to compare the efficacy and tolerability of indomethacin capsules and ketoprofen controlled-release capsules in the symptomatic treatment of coxarthrosis. MATERIALS AND METHODS:113 out-patients were enrolled: 57 were assigned to receive indomethacin 50 mg twice daily and 56 ketoprofen 200 mg once daily for 4 weeks. RESULTS:Indomethacin and ketoprofen proved equally effective in relieving osteoarticular pain and stiffness and in improving the quality of life of patients. There was essentially no difference as to gastrointestinal adverse events which occurred in 25% of patients on indomethacin and in 27% of those on ketoprofen. Indomethacin caused more non-gastrointestinal untoward effects, especially CNS effects (headache and dizziness: 11%) which were not observed with ketoprofen. Indomethacin was discontinued because of adverse events in a larger proportion of patients (20%) than ketoprofen (11%).
journal_name
Minerva Medjournal_title
Minerva medicaauthors
Marcolongo R,Canesi B,Ferri S,Oriente P,Perpignano G,Serni U,Tirri G,Trotta F,Dal Prà A,Lucchini Msubject
Has Abstractpub_date
1997-10-01 00:00:00pages
383-91issue
10eissn
0026-4806issn
1827-1669journal_volume
88pub_type
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