Spinal antinflammatory action of Diclofenac.

Abstract:

:Diclofenac is a non-steroidal antinflammatory drug (NSAID) that finds indication in the treatment of debilitating pathologies characterized by chronic pain sustained by inflammation, such as in rheumatic disease (rheumatoid arthritis or osteoarthritis) or periarthritis, bursitis, tendonitis, myositis and sciatica. Its properties differentiate it from other NSAIDs. In fact, diclofenac's increased effect on spinal nociception and chronic neuro-inflammatory pain may be referred to: 1) its synergistic effects on peroxisome proliferator-activated receptor-γ (PPAR- γ) activation and prostaglandin synthesis inhibition (COX-2 inhibition); 2) its capacity of suppressing neuronal hyperexcitability through the blockage of neuronal K+ channels in a concentration-dependant manner; and 3) its facility to cross the blood-brain barrier.

journal_name

Minerva Med

journal_title

Minerva medica

authors

Sandri A

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

167-72

issue

3

eissn

0026-4806

issn

1827-1669

pii

R10Y9999N00A16032501

journal_volume

107

pub_type

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