Abstract:
:Acarbose represents the first of a new class of oral antidiabetic drugs: the alpha-glucosidases inhibitors. This drug in fact delays the production of monosacchtarides inhibiting the alpha-glucosidases of the small bowel, that are responsible of digestion of complex polysaccharides and sucrose. In patients with insulin dependent diabetes mellitus (IDDM) acarbose, significantly reduces the postprandial blood glucose levels, and improves the symptoms associated with nocturnal hypoglycaemia reducing the daily insulin dosage. Furthermore acarbose ameliorates the glycemic control of obese patients when associated with hypocaloric diet. The aim of our study has been to value the effectiveness of acarbose 300 mg/day for 12 weeks in patients affected by moderate obesity (30 < - BMI < 40) and with impaired glucose tolerance (IGT). We have studied 12 patients, 6 have been treated with acarbose and hypocaloric diet, while the other 6 have been treated only with diet, these last formed the control group. Before and after the treatment, anthropometric indexes and haematologic parameters have been observed. Patients treated with acarbose presented a significative decrement of body weight, BMI, fat free mass, fat mass and of basal and peak glycaemic values after oral glucose tolerance test (OGTT). Serum lipid values, insulin levels during OGTT and blood pressure presented a not significative improvement. Gastrointestinal symptoms such as flatulence and borborygmus have been reported only in the patients treated with acarbose. The incidence of these reactions usually decreases with time.
journal_name
Minerva Medjournal_title
Minerva medicaauthors
Coli P,Pea E,Lacorte M,Passaglia C,Carrai Msubject
Has Abstractpub_date
1996-04-01 00:00:00pages
161-70issue
4eissn
0026-4806issn
1827-1669journal_volume
87pub_type
临床试验,杂志文章相关文献
MINERVA MEDICA文献大全abstract::A group of 104 workers were examined. They were employed in selecting rags and separating the lining from wollen fabrics to be used again as thread waste in the textile industry. The aim of the study was to point out tendon and joint related disorders of the upper limb due to repetitive and forced movements. Twenty-ei...
journal_title:Minerva medica
pub_type: 杂志文章,评审
doi:
更新日期:1995-11-01 00:00:00
abstract::In Italy, the attitude displayed by psychosomatists towards hypnosis and A.T. is decidedly favourable, since they are considered as forms of short-term psychotherapy, this being primarily indicated in the management of psychosomatosis. While some reservations may be expressed with regard to the employment of hypnosis ...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1975-10-31 00:00:00
abstract::The Authors for a better knowledge of the senile kidney have studied the urinary proteins of a group of elderly people resident in a geriatric institute. For instance they have noted the percentage of proteinuria in the urine of 313 patients (M and F) with various pathology, making also an electrophoresis of the urina...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1978-03-30 00:00:00
abstract::Reports in the literature on the difficulty of differential diagnosis between Disseminated Intravascular Coagulation (DIC) Pseudo-DIC and Primary Fibrinolysis (PF) in patients with liver disease, stimulated a study of various coagulation parameters (PT, PTT, Platelets, Fibrinogen, FDP) in 28 cirrhotic patients. The st...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1988-03-01 00:00:00
abstract::Daytime office blood pressure measurements (OBPM), still recommended and utilized today for diagnosis and management of hypertension and categorization of cardiovascular disease (CVD) risk, fail to reveal clinically important features of the mostly predictable BP 24 h pattern and leads to a large proportion of individ...
journal_title:Minerva medica
pub_type: 杂志文章,评审
doi:10.23736/S0026-4806.20.06834-2
更新日期:2020-12-01 00:00:00
abstract::Glaucoma is the leading cause of irreversible blindness worldwide. The World Health Organization reported in 1995 that 5.1 million persons were bilaterally blind from glaucoma. Its morbidity and prevalence make it a significant public health problem. Because it is a treatable condition, it is important that medical pr...
journal_title:Minerva medica
pub_type: 杂志文章,评审
doi:
更新日期:2001-10-01 00:00:00
abstract::The efficacy and tolerability of Cefoperazone sodium in the treatment of infections primarily of the lower respiratory and/or urinary tract were assessed. The drug was given to 16 intensive care patients encountered over a period of a few months. The results appear to be satisfactory and suggest that the drug is suita...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1987-11-15 00:00:00
abstract::In 16 patients with high cortisol plasma levels MRI and CT investigation of adrenal gland region was performed; 13 also had the pituitary region examined. CT and MRI results in Cushing's Syndrome due to adrenal glands etiology (8 cases) are overlapping. The morphological criteria utilized consist in the radiological f...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1990-01-01 00:00:00
abstract::A total of 237 patients with AIDS have been observed in the infectious Disease Division of the United Hospitals of Bergamo during the past six years. Five patients (4.21%), suffering from TB and PCP, revealed PNX which was characterised by being bilateral and recurrent; it was a concomitant cause of death in 2 patient...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract::The role of Tissue Factor (TF, thromboplastin) as the major factor in initiation of the blood coagulation process has been known for more than 100 years. Its importance for the development of clinical thrombosis, be it venous or arterial, and the complexity of the cell biology of TF, have however been increasingly app...
journal_title:Minerva medica
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::A comparison between echographic and bioptic findings in diffuse liver disease is reported. The data obtained are compared with those quoted in the literature and found to be very similar. Finally echography is identified as the indispensable examination of choice. ...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1986-05-12 00:00:00
abstract::Syncope is a frequent symptom in older patients. The diagnostic and therapeutic management may be complex, particularly in older adults with syncope and comorbidities or cognitive impairment. Morbidity related to syncope is more common in older persons and ranges from loss of confidence, depressive illness and fear of...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:2009-08-01 00:00:00
abstract::Loss of his social role and various other stresses result in a psychological feeling of impotence and nothingness in the aged. Physicians should make a close study of these aspects and not identify the aged with the end of finality and segregation. Adaptation to old age is determined by the years preceding it and doct...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1978-05-26 00:00:00
abstract::Venous thromboembolism (VTE) is a major cause of morbidity and mortality in patients with cancer. For over a decade, the gold standard of treatment and secondary prevention of cancer-associated thrombosis (CAT) has been represented by low-molecular-weight heparins (LMWHs), which are currently recommended as the first-...
journal_title:Minerva medica
pub_type: 杂志文章,评审
doi:10.23736/S0026-4806.19.06026-9
更新日期:2019-06-01 00:00:00
abstract::The endotoxin presence was tested by Limulus Lysate Test (LLT) in plasma and ascites of 29 patients with cirrhosis, all having demonstrable portal hypertension and ascite. It was positive in plasma in 7 cases (24.1%) and in ascite in 12 cases (73.12%). All the cases with endotoxin in the plasma were positive in ascite...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1981-06-16 00:00:00
abstract::To achieve an accurate diagnosis on the nature of pancreatic cystic lesions may be difficult. This review article attempts to provide an overview of the potential role of endoscopic ultrasound (EUS) and EUS guided fine needle aspiration in the evaluation of cystic lesions of the pancreas. ...
journal_title:Minerva medica
pub_type: 杂志文章,评审
doi:
更新日期:2007-08-01 00:00:00
abstract::Numerous factors may influence the sympathetic and pressure response to physical exercise, age, sex, type of activity carried on and training for example. Training, in particular is considered to reduce both adrenergic and pressure response. Plasma catecholamine levels and the haemodynamic response to the hand-grip te...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1988-11-01 00:00:00
abstract::The trend of antibodies tested with indirect hemagglutination, of total IgE and complement fraction was examined in patients with liver hydatid disease, treated with surgery and benzoimidazoles. ...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1989-12-01 00:00:00
abstract::The results obtained in a single blind controlled study using a new preparation, guacetisal, and an already available similar product based on dimethylaminophenazone guaiacolglycolate and calcium ethylcamphorate, are reported. The drugs were administered to 28 elderly patients of both sexes suffering from bronchopneum...
journal_title:Minerva medica
pub_type: 临床试验,杂志文章
doi:
更新日期:1981-02-28 00:00:00
abstract::The results of a pharmacokinetic and clinical study of cephamandol naphate indicated that the drug quickly reaches high plasma concentration after both i.m. and i.v. bolus administration. Urinary excretion of the biologically active form is as much as 84--90% of the total dose and mostly takes place in the first 6 hr....
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1980-05-26 00:00:00
abstract::13 patients aged between 69 and 85 suffering from atrial rhythm disease were examined. Special attention was paid to the relationships between this syndrome and acute cerebral vascular pathology. The series shows the high frequency in arrhythmic atrial disease of episodes of incipient loss of consciousness or authenti...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1976-07-14 00:00:00
abstract::Lactic acid dehydrogenase (LAD) levels were determined in 82 pleural effusion liquids and the respective blood samples from 58 patients. Effusions were classed as transudates and exudates on the basis of clinical and laboratory data. The 16 transudates had absolute protein levels of less than 3 g/100 ml and a liquid: ...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1975-11-28 00:00:00
abstract::Blood lipids and lipoproteins were evaluated in male and female subjects of various ages with acute myocardial infarct. Values were within the limits of normal in less than 50%, mostly in the aged. II B (24%), IV (18%) and II A (11%) lipoprotidaemic pictures were the most common. It is felt that abnormal values are no...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1977-03-17 00:00:00
abstract::Data reported in the literature on the existence of a circadian rhythm in PTH secretion are contradictory. In order to assess whether haematic PTH levels vary over a 24 hour period, the plasma levels of the hormone were evaluated at 6 different times during the day (12, 19, 24, 2, 4, 6 hours) in a group of 10 healthy ...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1985-06-30 00:00:00
abstract::We considered the case of an eighty-three-years-old woman who was admitted to Somma Lombardo Hospital, because of the presence of an acquired sideroblastic idiopathic anaemia accompanied by a cyclic hypereosinophilia of undefined significance. The case is reported both because references about sideroblastic idiopathic...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1990-05-01 00:00:00
abstract::The results are reported of a clinical and radiological study of a group of athletes that investigated the often asymptomatic alterations found in the spinal area. In comparison with non-athletic controls the sportsmen revealed a significantly higher incidence in the pars intearticularis of the posterior apophysis in ...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1985-11-30 00:00:00
abstract::It is repeatedly advocated in the medical literature the need of reshaping the care process in order to better address the unmet clinical needs of the highly vulnerable and complex ageing population. In the past twenty years, frailty has assumed the role of an arising and independent geriatric condition, different fro...
journal_title:Minerva medica
pub_type: 杂志文章,评审
doi:10.23736/S0026-4806.18.05821-4
更新日期:2018-12-01 00:00:00
abstract::When the cause of oesophagitis has been discovered, patients for whom surgical management is impossible may be successfully treated by improving oesophageal peristalsis, increasing the tone of the LES, and speeding up the emptying of the stomach. The best results are obtained in peptic oesophagitis, since the latest s...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1982-11-10 00:00:00
abstract::The results obtained at the end of the first three years of a hepatitis B vaccination campaign in Campania, are reported. HEVAC-B and H-B-VAX proved innocuous and efficacious in producing anti-HBs. Newborn babies and children produced anti-HBs more often and with higher titres than adults. Titre 10 mUI/ml of anti-HBs ...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::The ultrastructural change brought about by administration of oestrogens on articular cartilage were evaluated in the course of the present study. To this end 3 stabilized postmenopausal patients were selected who were to undergo bilateral hip prosthesis. After the first operation the patients were started on continuo...
journal_title:Minerva medica
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00