Abstract：
:It is well known that deep hypothermia used in open-heart surgery is usually associated with a marked reduction in carbohydrate tolerance, especially dangerous in the diabetic patient, since it might result in severe metabolic complications, namely ketosis and hyperosmolar coma. In order to prevent the occurrence of such complications we treated an insulin-dependent diabetic patient undergoing cardiovascular surgery, with a feed-back insulin infusion operated by an artificial pancreas (GCIIS, Biostator). The Biostator was then used to perform a continuous (minute by minute) blood glucose monitoring in 2 more patients, a type II (non insulin-dependent) diabetic and a non diabetic. Blood samples were drawn sequentially in order to determine plasma free insulin concentration. The glycemic profile observed in the insulin-dependent diabetic under artificial pancreas treatment was similar to that in the non-diabetic. Plasma free insulin levels dropped near to zero during by-pass cooling, returning toward basal level during the rewarming phase. Such results are then discussed by the Authors and given a pathogenetic interpretation.
journal_name
Minerva Medjournal_title
Minerva medicaauthors
Calabrese G,Bueti A,Zega G,Bellomo G,Antonella MA,Giombolini A,Tardioli F,Massi-Benedetti M,Palminiello Asubject
Has Abstractpub_date
1982-12-22 00:00:00pages
3509-14issue
49-50eissn
0026-4806issn
1827-1669journal_volume
73pub_type
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