Abstract：
:Two experimental models for pure red cell aplasia (PRCA) were established. In the first one, administration of PRCA serum IgG in normal mice induced a sustained inhibitory effect on erythropoiesis, a progressive decline of the hematocrit values and an inverse rise of erythropoietin (Ep) levels in serum. Thus, the physiopathological pattern of PRCA type I (or A) was established, In the second model a rabbit producing anti-Ep crossreacting with endogenous Ep was subjected to a booster injection of Ep. The rise of the immune response was associated with decrease of Gct values and disappearance of erythroid precursors from marrow smears, and its subsequent decline with reticulocytosis and regression of the anemia, thus reproducing the physiopathological pattern of PRCA type II (or B).
journal_name
Minerva Medjournal_title
Minerva medicaauthors
Genovese A,Marone G,Buccelli C,Peschle Ckeywords:
subject
Has Abstractpub_date
1975-01-24 00:00:00pages
203-8issue
5eissn
0026-4806issn
1827-1669journal_volume
66pub_type
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