Abstract：
BACKGROUND:Acute liver failure (ALF) is a rare but often lethal syndrome. In Italy, recent data on its incidence and causes are lacking. We report here the epidemiological analysis of ALF cases observed in Campania, a Southern Italian region, over the last 25 years. METHODS:Medical records of ALF cases hospitalized from 1992 to 2018 were retrospectively analyzed. RESULTS:Two hundred ten ALF cases occurred during 1992-2018: 103 (49%) hepatitis B virus (HBV)-related (including 5 cases also infected with Delta virus), 39 (19%) from undetermined cause, 36 (17%) drug-induced, 11 (5%) Wilson's disease-associated, 8 (4%) hepatitis A virus (HAV)-related and 12 (6%) from other causes. Separate time-periods analysis of data showed a significant progressive decrease in ALF incidence mainly attributable to a decline of HBV and other viruses etiology. Already before 2010, HAV or Delta virus-related cases have no longer been observed. No hepatitis C or E virus-related ALF was detected through the study period. A progressive decrease in frequency of ALF due to undetermined causes or drug was also evident. CONCLUSIONS:A decrease in ALF incidence and a changing in its etiology were observed in Campania during 1992-2018. Both results were likely mainly due to 1991 introduction of HBV universal vaccination and may be considered generalizable nationwide.
journal_name
Minerva Medjournal_title
Minerva medicaauthors
Amoroso P,Buonocore S,Lettieri G,Pesce G,Pierri P,De Sena R,Morelli G,Matteis B,Dell'isola C,De Marino V,Ciccaglione AR,Punzi R,Esposito C,Spada Edoi
10.23736/S0026-4806.19.06331-6subject
Has Abstractpub_date
2020-08-01 00:00:00pages
330-336issue
4eissn
0026-4806issn
1827-1669pii
S0026-4806.19.06331-6journal_volume
111pub_type
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