Role of niacin in current clinical practice.

Abstract:

:Despite significant risk reduction with statin therapy, there remains a residual cardiovascular risk. It has been seen that aggressive statin therapy in high risk patients may not lower the low-density lipoprotein cholesterol to goal in up to 40% of patients. Niacin is a potent high-density lipoprotein cholesterol-raising drug, and has been proposed as an attractive approach to reduce cardiac events in patients with or at risk of atherosclerotic cardiovascular disease. However, previous evidence for niacin has been challenged by negative outcomes in two large, randomized, controlled trials comparing niacin to placebo with background statin therapy. In this review, summarize the currently available evidence for the role of niacin treatment for reducing the risk of cardiovascular events in current practice.

journal_name

Minerva Med

journal_title

Minerva medica

authors

Sharma A,Madan N

doi

10.23736/S0026-4806.18.05826-3

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

79-83

issue

1

eissn

0026-4806

issn

1827-1669

pii

S0026-4806.18.05826-3

journal_volume

110

pub_type

杂志文章,评审
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  • [Relationship between blood fibrinogen and plasma lipoproteins in patients with hypercholesterolemia].

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  • [Serology study for HBV and HIV-1 in a cohort of parenteral drug addicts].

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  • [Evaluation of the efficacy and tolerance of radioactive fangotherapy in gonarthrosis. Comparative study versus short wave therapy].

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    authors: Fioravanti A,Bisogno S,Nerucci F,Cicero MR,Locunsolo S,Marcolongo R

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  • [The central nervous system and appetite: possible sites of activity for food intake therapy].

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  • [Short term assessment of anthropometric indices and metabolic parameters in obese subjects treated with acarbose].

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  • [Fiber bronchoscopy in the diagnosis of bronchopulmonary tumors. Evaluation of the diagnostic efficacy of a cyto-histologic protocol in an ambulatory center].

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  • [Muscular diseases: epidemiology of progressive muscular dystrophies].

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    doi:

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  • [Idiopathic hypereosinophilic syndrome. Current clinico-therapeutic state].

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  • [Male Accessory Gland Infections (MAGI): patient questionnaire and additional ultrasonography criteria].

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  • [Clinico-statistical considerations on the agreement between echographic and biopsy findings in hepatopathies of the diffuse type].

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  • [13 years of Australia antigen. Critical notes].

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  • [Effectiveness of and tolerability to oral desmopressin in the treatment of central diabetes insipidus].

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  • [Prevalence of surface antigens (HBsAg), surface antibody (HBsAb) and anticore antibody (HBcAb) in hospital personnel and patients with and without hepatic pathology].

    abstract::We studied hepatitis B virus surface antigen (HBsAg), surface antibody (HBsAb) and "core" antibody (HBcAb) prevalence in 166 among hospital personell and patients with and without liver disease. Results show there is a very high prevalence of hepatitis B virus markers in such populations and the presence of HBcAb in a...

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  • [The value of the basophil degranulation test on the study of hypersensitivity reactions to iodinated contrast media].

    abstract::The ability of basophils and tissue mastocytes activated by sensitised IgE antibodies to release mediators in the presence of the specific antigen underlies immediate hypersensitivity reactions. This phenomenon can be explored by the in vitro basophil degranulation test adopted not only in experimental pathology, but ...

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  • [Hepatitis B and D recurrence after liver transplantation].

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  • [Parsalmide, a new synthetic substance, in inflammatory and arthrosic arthropathies. Double-blind controlled clinical trial].

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    pub_type: 杂志文章,评审

    doi:

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  • [The combination acetominophen/tramadol in hematological daily practice].

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  • [Laurence-Moon-Biedl syndrome associated with tertiary hypothyroidism. A case report].

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    doi:

    authors: Capellini Q,Barba G

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