Abstract：
BACKGROUND:New direct antiviral agents (DAA) are now effective in hepatitis C virus (HCV) infection; persons living with human immunodeficiency virus (HIV) (PLWH) were undertreated. Aim of this study was to describe the management of HCV treatment in a HIV/HCV cohort during a 16 years period. METHODS:An electronic review of all HIV patients with >1 clinic check from the year 2000 was made. Demographic, virologic and treatment data were collected. RESULTS:From 2000 to 2015 a total of 2352 PLWH were enrolled; 776 (33%) resulted positive at HCV antibodies, and were mostly genotype 1 and 3. 279/579 (48.2%) were treated, and 170 (29.3% of total, 60.9% of treated) obtained a SVR. Treatment rate for HCV had a significant increase in the 2015 (20.6%, P<0.05 when compared with previous years). SVR rate was significantly improved in the 2015 (P<0.05 when compared with each single previous year). At univariate analysis among the different year group there were significant differences in term of HCV RNA positive patients (P<0.001), number of treated (total) and naïve patients (P<0.001 in each of cases), SVR rate (P<0.001), mortality rate (P=0.003). HCV-Ab positive patients with HCV-RNA not detectable (cured) increased during years. At 2015, 50.4% of the HCV-Ab positive patients resulted to be HCV-RNA negative. CONCLUSIONS:In the DAA's era a significant increase in the number of treatments was observed. SVR rate was significantly higher. Treatment rate still remains quite low. More than a half of our population of HCV co-infected patients results to be cured for HCV.
journal_name
Minerva Medjournal_title
Minerva medicaauthors
Cuomo G,Puzzolante C,Lazzaretti C,Guaraldi G,Borghi V,Mussini Cdoi
10.23736/S0026-4806.18.05435-6subject
Has Abstractpub_date
2018-06-01 00:00:00pages
203-210issue
3eissn
0026-4806issn
1827-1669pii
S0026-4806.18.05435-6journal_volume
109pub_type
杂志文章相关文献
MINERVA MEDICA文献大全abstract：:Cystic fibrosis (CF) is the most common genetic disorders in the Caucasian population, with estimated between 70,000 and 100,000 patients worldwide. Even if improved diagnostics and clinical management have led to an increased life expectancy, CF still remains a disease that significantly impacts patients' life in ter...
journal_title：Minerva medica
pub_type： 杂志文章,多中心研究,评审
doi：
更新日期：2015-10-01 00:00:00
abstract：:Ten subjects with peripheral arterial occlusive disease were treated with buflomedil, analysing the effect of every single intravenous administration of the drug, and the effect of the administration repeated for a period of 5 days. This controlled study was aimed at evaluating the state of the peripheral blood flow, ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1985-02-25 00:00:00
abstract：:A marker of neuroendocrine differentiation, neuron-specific enolase (NSE) is assessed in the diagnosis of small cell lung cancer (SCLC). The market was found to be highly sensitive and extremely specific in high risk groups (smokers and chronic bronchitics). ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1987-04-15 00:00:00
abstract：:Personal experience with acute enzymatic pancreatitis in 113 cases observed, over 11 years, at the Santa Croce Hospital Surgical Division is described. Only 58 cases (51,3%) were submitted to surgery and the remaining 55 cases (48,7%) were treated with medical therapy. A mortality of 16,8% was observed. ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1977-05-05 00:00:00
abstract：:After examining the most recent findings on the physiopathology of the renin-angiotensin system, techniques are analysed for the determination of renin activity (PRA). These are still inadequate and imprecise, notwithstanding radioimmunological techniques and stress is laid on the importance of their standardisation. ...
journal_title：Minerva medica
pub_type： 杂志文章,评审
doi：
更新日期：1980-09-08 00:00:00
abstract：:18 cases of anatomically verified lung cancer were studied scintigraphically with microspheres of human albumin labelled with 99Tc, mercury bichloride (197Hg) and citrate of gallium (67Ga), to assess the diagnostic value of this technique. Using albumin microspheres, changes in the scintigraphic picture were obtained ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1976-10-27 00:00:00
abstract：:Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and its prevalence is increasing with age. With aging of the population treatment of atrial fibrillation especially in elderly population is a growing task for all medical staff working with elderly patients. Treatment of atrial fibrillation espe...
journal_title：Minerva medica
pub_type： 杂志文章,评审
doi：
更新日期：2009-04-01 00:00:00
abstract：AIM:The aim of the study was to evaluate the effect on the articular pain of 100 mg of disodium-clodronate administered for 6 days a week by intramuscular injection in rheumatoid arthritis (RA) patients. METHODS:We studied 46 patients (38 females and 8 males middle age 57+/-6.2 years, range from 30 to 80 years) with e...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
abstract：AIM:Hyponatremia, an electrolyte disturbance, can be due to loss of solutes or to an increase of ''free'' water concentration, predominantly caused by excessive antidiuretic hormone (ADH) secretion. When acute, hyponatremia is threatening, because it can cause cell swelling and severe neuromuscular symptoms (central po...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：2008-04-01 00:00:00
abstract：:The A.A. report a case of duodenal ulcer observed in a young patient, showing at the same time and associated the three known complications of this disease. After gastric resection, urgently performed, followed a favourable post-operative course and a very good result at distance. On a study of 710 patients with gastr...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1975-10-13 00:00:00
abstract：BACKGROUND:Several studies demonstrate that the adherence to asthma guidelines (GL) is poor, but only a few of them were performed in community pharmacies. Thus, we decided to study this phenomenon by administering a questionnaire (Q) in two pharmacies. METHODS:A Q was developed and administered to 138 patients-custom...
journal_title：Minerva medica
pub_type： 杂志文章,多中心研究
doi：
更新日期：2003-02-01 00:00:00
abstract：:The use of xeroradiography for the study of lipomas (limbs, thoracic wall, pelvic and shoulder girdles) was evaluated on 36 consecutive patients; in 16 cases (44%), histological diagnosis on the surgical specimen was also available. Xeroradiography was more effective than standard x-ray films in 13 cases of 14 submitt...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1980-02-25 00:00:00
abstract：AIM:Corticosteroids, antidopaminergig agents and 5-HT3 antagonists are the most commonly used drugs in the treatment of chemotherapy-induced vomiting. Acupuncture and acupressure have also appeared to exert antiemetic effects. The aim of this study was to evaluate the efficacy of acupressure in the treatment of chemoth...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：2006-10-01 00:00:00
abstract：:Certain applications of radioisotopes to obstetric and gynaecological diagnosis are illustrated. Radioisotopes have been widely employed since the improvement in instrumental methods and the availability of short-life radioisotopes has removed the basic limitation which once prevented their use during the entire fecun...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1975-12-12 00:00:00
abstract：:Two patients with heart failure and Cheyne-Stokes breathing are presented. We have discussed the possible physiopathological mechanism of Cheyne-Stokes breathing and clinical, instrumental and laboratory data for a correct diagnostic evaluation. ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:An account of the effects of recent influenza epidemics is given from the medical standpoint, and also with respect to their social and economic repercussions. The part played by air travel in the carriage of such epidemics is also examined. The immunity of the population of Rome towards an A strain swine fever (A/New...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1976-10-17 00:00:00
abstract：:Two cases of Lyell's syndrome (toxic necrolysis of the epidermis) are reported on account of their rarity. The differential diagnosis of this form and its aetiopathogenesis and treatment are described. ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1975-12-15 00:00:00
abstract：:The new developed histamine H2-receptor antagonist ranitidine has proven to be a more potent and longer acting anti-secretory compound than cimetidine both after intravenous as well as oral administration. A daily dose of 200-300 mg ranitidine should correspond to 1.0-1.2 g cimetidine in the acute therapy of duodenal ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1981-10-20 00:00:00
abstract：:The therapeutic effectiveness and tolerability of diphthalone and indomethacine administered for long periods were compared in 10 patients suffering from rheumatoid arthritis in the active phase. Each patient was treated with one of the two drugs on a double blind basis. Diphthalone proved to be more active than indom...
journal_title：Minerva medica
pub_type： 临床试验,杂志文章
doi：
更新日期：1976-03-10 00:00:00
abstract：:Microbial maps were performed taking swabs from nose, pharinx, external auditory meatus, groin, vagina, sputum and urine cultures in 69 cases of acute leukaemia, in order: to assess the germs' incidence in an "open ward" department; to eliminate the most dangerous pathogens with local treatment or with a selective the...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1976-12-29 00:00:00
abstract：:Aim of this study was to re-evaluate the overall prevalence of a peptic disease in 350 patients with liver diseases of different etiology and severity. A normal endoscopic picture was found in 82% of cases. Peptic lesions were found in 18% of total cases and were located in the duodenal (10.9%) and gastric (7.1%) wall...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1986-10-13 00:00:00
abstract：:Longitudinal research has shown that social failure to adjust can be prevented by early removal of ambiental factors encouraging pathological development of the Ego, and the detection and treatment of psychological tendencies towards the acquisition of deviant stimuli. ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1975-09-12 00:00:00
abstract：:Single-dimensional echocardiography was used in the study of 15 patients with congestive cardiomyopathy. The main signs for the diagnosis of this disease and its differentiation from atherosclerotic coronaropathy were determined. Mitral and aortic echograms were examined along with the ventricular parameters in order ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1981-09-19 00:00:00
abstract：:The technical specifications of Ilizarov's fixator and its numerous applications in orthopaedics and traumatology are systematically analysed. ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1988-04-01 00:00:00
abstract：AIM:The aim of this analysis was to investigate the clinical characteristics and prognosis of patients with serum alpha-fetoproteinpositive gastric cancer (AFPGC) in order to improve the diagnosis and treatment. METHODS:A retrospective analysis was performed on the clinical characteristics and survival data of patient...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：2015-08-01 00:00:00
abstract：:28 cases of carcinoma of the digestive tract were studied in order to assess the value of assaying a new tumour marker (CA 19-9) on monitoring the postoperative course of neoplasia. CEA, a tumour antigen of more certain dependability was assayed at the same time. In the case series examined it was found useful to moni...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1986-11-10 00:00:00
abstract：:The literature reports many cases of eosinophilic pulmonary infiltrations, with different etiology. In our case clinical pictures were not very clear and specific at first and the clinical course was altered by an ex adjuvantibus steroid treatment before admission to hospital. It was new and unusual because it present...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1994-09-01 00:00:00
abstract：:The Authors refer their experience using endoscopy, biopsy and 24 hours pHmetry associated in 62 patients with symptomatology of reflux. In 21 cases it was shown different grades of esophagitis, in 12 cases reflux potentially pathological. The Authors refer that this association in studying reflux is very comfortable ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1984-09-29 00:00:00
abstract：:Heart rate is a parameter that is very easy to measure and is widely used both in clinic and during daily life activities. Its value gained more relevance with the evidence, in prospective studies and meta-analysis, of association between elevated heart rate values and diseases and outcomes.The increased knowledge of ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：10.23736/S0026-4806.20.06695-1
更新日期：2020-06-05 00:00:00
abstract：:TPA and CEA were both assayed in a population of 352 diseases of the gastroenteric tract and control subjects. The results show that TPA though sensitive has no predictive value or specificity comparable to CEA. However should specific tumour markers prove negative TPA may be an extremely useful aid in monitoring pati...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1986-04-14 00:00:00
