Abstract：
AIM:The aim of the study was to evaluate the effect on the articular pain of 100 mg of disodium-clodronate administered for 6 days a week by intramuscular injection in rheumatoid arthritis (RA) patients. METHODS:We studied 46 patients (38 females and 8 males middle age 57+/-6.2 years, range from 30 to 80 years) with established RA, in the II and III anatomical stage according to Steinbrocker. Therapeutic regimen was for all patients oral methotrexate 7.5 mg weekly, prednisone 7.5 mg/day and AINS. All of these patients also received disodium-clodronate 100 mg for 6 days a week for 6 months. The results of the VAS for pain, the patient global assessment and the physician global assessment on disease activity have been recorded at baseline, at the 2 months and at 6 months of therapy. RESULTS:VAS for pain and patient global assessment of disease activity values decreased significantly after 2 months of therapy (p<0.01) and in comparing basal versus final observation, but they did not change significantly from month 2 to month 6. The score of physician global assessment on disease activity was found to be significantly improved comparing the basal versus 2 months observation, and 2 months versus 6 months observations (p<0.01). CONCLUSION:Disodium-clodronate may be considered an adjunctive therapy in the pain management of RA patients.
journal_name
Minerva Medjournal_title
Minerva medicaauthors
Rovetta G,Monteforte Pkeywords:
subject
Has Abstractpub_date
2003-10-01 00:00:00pages
353-7issue
5eissn
0026-4806issn
1827-1669journal_volume
94pub_type
杂志文章相关文献
MINERVA MEDICA文献大全abstract：:In Italy, the attitude displayed by psychosomatists towards hypnosis and A.T. is decidedly favourable, since they are considered as forms of short-term psychotherapy, this being primarily indicated in the management of psychosomatosis. While some reservations may be expressed with regard to the employment of hypnosis ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1975-10-31 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the incidence and the characteristics of the infections of ascitic fluid in cirrhotic patients at the moment of hospital admission. METHODS:A total of 314 patients consecutively submitted to ascitic fluid tap within 3 days of hospital admission were studied. Each patien...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1999-10-01 00:00:00
abstract：:A total of 237 patients with AIDS have been observed in the infectious Disease Division of the United Hospitals of Bergamo during the past six years. Five patients (4.21%), suffering from TB and PCP, revealed PNX which was characterised by being bilateral and recurrent; it was a concomitant cause of death in 2 patient...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:The results of a pharmacokinetic and clinical study of cephamandol naphate indicated that the drug quickly reaches high plasma concentration after both i.m. and i.v. bolus administration. Urinary excretion of the biologically active form is as much as 84--90% of the total dose and mostly takes place in the first 6 hr....
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1980-05-26 00:00:00
abstract：:The effect of road noise on blood catecholamines, cAMP and certain cardiovascular and metabolic parameters was studied in a group of young untreated essential hypertensives. It was found that the 10' stimulus increased both systolic and diastolic pressure values. Blood catecholamines rose only after 5'. The most signi...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1984-10-20 00:00:00
abstract：:The frequency of thyroid alterations was examined and dietary iodine intake was assessed via urinary iodine in 6-15 yr-old schoolchildren from 145 towns in Piedmont and the Aosta Valley. Local food iodine values were also determined in 56 towns. Alteration frequency and daily urinary elimination of iodine were inverse...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1975-10-17 00:00:00
abstract：:The diagnostic possibilities of Doppler velocimetry with spectral analysis have been assessed in the diagnosis of benign and malignant breast cancers. The study considers 18 patients with mammary nodules. The data obtained with Doppler velocimetry are compared with those of mammographic, cytological and histopathologi...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：BACKGROUND:The synthetic mucolytic neltene-xine is an amide derivative of ambroxol and thiophencarboxylic acid. The aim of this open, randomised, controlled study versus sobrerol was to evaluate the efficacy and tolerability of neltenexine (oral granules in sachets) as compared with sobrerol (oral granules in sachets),...
journal_title：Minerva medica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2001-08-01 00:00:00
abstract：AIM:Plasmodium falciparum (P. falciparum) malaria is the most important parasitic infection of humans, responsible for about 2,000,000 deaths every year. Cytoadherence of P. falciparum parasitized erythrocytes (pRBC) to vascular endothelium contributes to the pathogenesis of severe malaria causing microcirculatory obst...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：2004-04-01 00:00:00
abstract：:Insulin resistance (IR) has profound, negative effects on the function of arteries and arterioles throughout the body and leads to arterial hypertension and vascular occlusive diseases such as heart attacks and strokes. IR affects arteries and arterioles at both the endothelium and smooth muscle levels. One major, und...
journal_title：Minerva medica
pub_type： 杂志文章,评审
doi：
更新日期：2005-08-01 00:00:00
abstract：:Atherosclerosis risk factor, 8,5% two, 2,7% three and 0,6% four.rs have been investigated in 194 males and 135 female, 25 years old. Elevated lipids were found in 7,3% of the sample; "labile" and stable hypertension in 2,7%; diabetes mellitus in 2,7% and overweight in 19%. 19% of the subjects smoked more than 20 cigar...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1976-12-01 00:00:00
abstract：:Of 533 patients over 65 years old (153 males and 380 females), admitted to geriatric units for various medical diseases, 111 (20.8%) were anemic. Among males the prevalence of anemia was 30.1%, among females 17.1%. Three principal causes of anemia were revealed. The most frequent (42.3%) was microcytic, hypochromic an...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Acute liver failure (ALF) is a rare but often lethal syndrome. In Italy, recent data on its incidence and causes are lacking. We report here the epidemiological analysis of ALF cases observed in Campania, a Southern Italian region, over the last 25 years. METHODS:Medical records of ALF cases hospitalized fr...
journal_title：Minerva medica
pub_type： 杂志文章
doi：10.23736/S0026-4806.19.06331-6
更新日期：2020-08-01 00:00:00
abstract：:This study reports data concerning the prevalence of anti HCV in a population of 166 drug addicts and 25 partners (14 drug addicts and 11 with no history of substance abuse) of subjects proven anti HCV positive. The study was carried out in order to evaluate the importance of the haematic and sexual modes of transmiss...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：:A synchronised programme consisting of VCR, CTX and MTX has been employed in 57 patients suffering fom lung carcinoma. Average survival was 10.6 months and overall tolerance was good. The best indications are intermittent long-term treatment and retreatment of patients with cancer recalcitrant to the same drugs. With ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1981-06-23 00:00:00
abstract：:Endoscopic mucosal resection has become the standard of care for early gastrointestinal cancer. The application of this new treatment requires an accurate stadiation of the neoplasia. The exclusion of nodal involvement and the evaluation of the depth of tumor penetration within the gastrointestinal wall is essential t...
journal_title：Minerva medica
pub_type： 杂志文章,评审
doi：
更新日期：2007-08-01 00:00:00
abstract：: ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：10.23736/S0026-4806.19.06248-7
更新日期：2019-09-06 00:00:00
abstract：:The Authors describe the clinical symptoms of malignant brain tumors emphasizing the relationship to raised intracranial pressure and to their different localizations. Problems involved in surgical therapy are described stating the limits and aims of conventional oncologic neurosurgery. The need for adequate pre and p...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1984-05-19 00:00:00
abstract：:Reference is made to personal experience of psycholability is most patients with cardiac achalasia in presenting the results of a preliminary study of the relation between psychic trauma and the onset of this affection, in which a retrospective investigation was made of 47 clinical records prepared for surgical purpos...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1984-02-28 00:00:00
abstract：:Cervicocephalic chemodectomas are rare non-chromaffin paraganglionic tumours, most often originating in the carotid body or the jugular ganglion. Their main features are a reluctance to invade adjacent tissue and the absence of general clinical signs. Since they are histologically quite varied they may at times be dif...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1983-12-15 00:00:00
abstract：:Possible correlations between lipid metabolism and hydroelectrolytic and acid base balances were studied in pathological conditions. For this purpose 24 patients with essential dyslipidaemia without renal or hepatic disease, and 47 patients with varying disease conditions, 25 with profound alterations in the lipid bal...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1977-02-18 00:00:00
abstract：:A physiopathological approach to the treatment of chronic pneumogenous respiratory insufficiency is proposed. To this end, disturbances of the ventilatory and alveolocapillary stages of the pulmonary respiratory function are discussed. Particular attention to distribution and diffusion disturbances and the main diseas...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1978-12-08 00:00:00
abstract：:A case of dyslipoproteinaemia of type V in a woman suffering from primary hypothyroidism, florid diabetes mellitus and obesity is reported. The case is commented on in general and as regards possible correlations between the diseases and the dyslipoproteinaemic picture. The various therapeutic treatment employed and r...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1976-07-21 00:00:00
abstract：:Urinary infections often complicate the clinical course of hospitalised patients especially those with immunological diseases or under antibiotic treatment for other infectious pathologies. Urethral catheterisation is also a well known cause of such infections. The problem of urinary infections was examined in a gener...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1986-07-14 00:00:00
abstract：:In order to discover more about the role of the sympathetic nervous and renin-angiotensin systems in the preservation of homeostasis during chronic reductions of salt intake, blood pressure, blood catecholamines and renin activity were measured in a group of healthy subjects in normal conditions and on a salt-free die...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1987-12-15 00:00:00
abstract：BACKGROUND:Several studies demonstrate that the adherence to asthma guidelines (GL) is poor, but only a few of them were performed in community pharmacies. Thus, we decided to study this phenomenon by administering a questionnaire (Q) in two pharmacies. METHODS:A Q was developed and administered to 138 patients-custom...
journal_title：Minerva medica
pub_type： 杂志文章,多中心研究
doi：
更新日期：2003-02-01 00:00:00
abstract：:Two cases of fibroadenoma phyllodes examined in the senological outpatient department of the Infermi Hospital, Biella between june and october 1987, described and diagnosed by senography and echography and confirmed by histological examination of the operating piece are presented. ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:The short-term (30 days) effects of lithium carbonate on ADH secretion, urinary enzyme secretion (specific markers of tubular damage), fractional excretion of sodium, calcaemia, calciuria and fractional reabsorption of phosphate, plasma and urinary Ca, urea and creatinine clearance were assessed in 15 female patients ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1986-02-28 00:00:00
abstract：:The authors describe a case of lymphoblastic lymphoma of the renal lodge complicated by hemorrhagic pericarditis, cardiac tamponade and quickly evolved in an unfavourable way. Lymphoblastic lymphoma is classified into lymphocytic lymphomas (or non-Hodgkin) with a higher grade of malignancy. These lymphomas have, in 40...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:Multivaried and trend analyses were applied to a set of 27 periodic haematochemical checks on 37 patients given surgery for biliopancreatic pathology. Preoperative and postoperative data were separately analysed. The software employed was specially designed for the purpose. The discriminating function was used in the ...
journal_title：Minerva medica
pub_type： 杂志文章
doi：
更新日期：1983-02-25 00:00:00
