[Functional compromise of the small airways in subjects exposed to SiO2].

Abstract:

:Aims of our study were: to evaluate small airway function of subjects with past or present silica dust exposure and normal spirometric values; to investigate whether small airway disease is related to radiographic signs of silicosis, to cumulative dust exposure (ES) and to cigarette smoking. Maximal expiratory flow at 50% (MEF50) and 25% (MEF25) of forced expired vital capacity were measured in 112 subjects, 69 with radiographic signs of silicosis, group I, and the remaining 43 with normal chest X-rays. Even if age and ES were significantly higher in group I, no significant difference in respiratory function tests and in prevalence of small airway disease was found between the two groups. In both groups small airway function was significantly negatively related to smoking habits, while it was independent of the other variables considered. Multiple regression analysis with MEF50 and MEF25 as dependent variables did not show any significant relationship. We conclude that small airway disease due to encroachment of bronchiolar walls by SiO2 deposition is masqued by the damage produced by cigarette smoking, even in the presence of radiographic signs of silicosis.

journal_name

Minerva Med

journal_title

Minerva medica

authors

Avolio G,Cacciabue M,Rolla G,Caria E,Oliaro A,Carlino F,Pepino E,Polizzi S,Bucca C

subject

Has Abstract

pub_date

1986-11-30 00:00:00

pages

2183-5

issue

45-46

eissn

0026-4806

issn

1827-1669

journal_volume

77

pub_type

杂志文章
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  • [What is in the future for geriatrics? I].

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    authors: Berde B,Fanchamps A

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    doi:

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    pub_type: 杂志文章,评审

    doi:

    authors: Niscola P,Tendas A,Giovannini M,Scaramucci L,De Sanctis V,Cupelli L,De Fabritiis P

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    doi:

    authors: Del Corso L,Vannini A,De Marco S,Gnesi A,Pentimone F

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  • [Analgesic effects of natural growth hormone release inhibitors and their synthetic analogs. Intraspinal administration].

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    pub_type: 杂志文章,评审

    doi:

    authors: Beltrutti D,Debernardi F,Pelosi G

    更新日期:1997-01-01 00:00:00

  • [Supraventricular tachycardia in children].

    abstract::Supraventricular tachycardia is one of the most frequent arrhythmias in childhood. It may accompany congenital heart disease. W.P. W. syndrome, or a normal state of health. A re-entry circuit is the most commonly observed electrophysiological mechanism. Persistence is followed by decompensation. Drug management is bas...

    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Battaglia T,Paparo F,Fumarulo A,Attanà A,Ciconte V,Caristo S,Primerano,Martini B

    更新日期:1983-12-15 00:00:00

  • [The role of aviation in the epidemiology of smallpox].

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    pub_type: 杂志文章

    doi:

    authors: Cavaricci A

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  • [Ultrasonography in diseases of lymph nodes and soft tissues of the neck].

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    pub_type: 杂志文章

    doi:

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  • [Citicoline activity in senile mental decay].

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    pub_type: 杂志文章

    doi:

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    abstract::The effect of somatostatin on plasma sugar and insulin levels was determined in 8 normal, 7 diabetic and 5 acromegalic subjects. An absolute fall in blood sugar values on the order of about 20% was noted, though during administration of the drug only, in all cases. Normal and diabetic subjects also showed an approxima...

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    pub_type: 杂志文章

    doi:

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    doi:

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    doi:

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    doi:

    authors: Balestri PL,Berni R,Cupisti A,Giordani R

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  • [Use of the M.H.Q. test (Middlesex Hospital Questionnaire) in the diagnosis of neuroses].

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    pub_type: 杂志文章

    doi:

    authors: Cornia C,Lorenzini R

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  • [Metabolic aspects of obesity].

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    journal_title:Minerva medica

    pub_type: 杂志文章

    doi:

    authors: Muntoni S

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  • [Neuron-specific enolase in bronchial carcinoma. Immunohistochemical and immunoenzyme study].

    abstract::Serum level of neuro-specific enolase (NSE) was determined in 20 lung cancer patients. NSE concentration was detected also on neoplastic tissue and NSE-positive neoplastic cells on histological sections were observed immunohistochemically. The presence of high level of NSE was showed in small cell lung cancer. ...

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    doi:

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  • [Evaluation of the diagnostic role of the carcinoembryonic antigen in ascitic fluid].

    abstract::The diagnostic role of carcinoembryonic antigen (CEA) in ascitic fluid was evaluated in order to assess whether or not ascitic haemorrhage is related to cancer. A total of 30 patients with ascitic haemorrhage were analysed (17 had cirrhosis, 5 non-metastasised cancers and 8 metastasised cancers). CEA radioimmunoassay ...

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    doi:

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    journal_title:Minerva medica

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    doi:

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    doi:

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  • [Cardiac muscle malacia as the factor inhibiting myocardiac electric stimulation, as seen in echocardiographic examination].

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    pub_type: 杂志文章

    doi:

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    pub_type: 杂志文章

    doi:

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  • [Therapy of arterial hypertension in diabetic patients. When to start the treatment and which drugs to use?].

    abstract::In this review, the Authors analyzes the more recent data in the Literature about the major cardiovascular risks in diabetic patients affected by systemic arterial hypertension. The more effective pharmacological and not pharmacological treatment is suggested. Particularly the advantages and more important side-effect...

    journal_title:Minerva medica

    pub_type: 杂志文章,评审

    doi:

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    更新日期:1992-11-01 00:00:00

  • [3 cases of paraneoplastic syndrome caused by lymphoma of the small intestine].

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    pub_type: 杂志文章

    doi:

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  • [Subarachnoid hemorrhage of unknown etiology: management, prognosis, and predictive factors].

    abstract::Thirty-nine consecutive patients with subarachnoid hemorrhage (SAH) of unknown etiology were studied retrospectively. A significant relationship between arterial hypertension, blood on CT and angiographic spasm was found. The use of nimodipine was associated with a reduction of vasospasm. Antifibrinolytic agents did n...

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    doi:

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