Abstract:
:In a mouse model of thermal injury, an increase in burn size produced a decrease in the ratio of Candida albicans cells adherent to the marginal zone to those adherent to the white pulp of the spleen, an increase in the number of Candida cells in the circulation and in the kidneys, and an increase in mortality.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Neely AN,Orloff MM,Holder IA,Healy DPdoi
10.1128/IAI.65.8.3493-3495.1997subject
Has Abstractpub_date
1997-08-01 00:00:00pages
3493-5issue
8eissn
0019-9567issn
1098-5522journal_volume
65pub_type
杂志文章abstract::To characterize the roles of Porphyromonas gingivalis and its components in disease processes, we investigated the cytokine profiles induced by live P. gingivalis, its lipopolysaccharide (LPS), and its major fimbrial protein, fimbrillin (FimA). A cytokine antibody array revealed that human monocyte-derived macrophages...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.2.1204-1214.2006
更新日期:2006-02-01 00:00:00
abstract::Our previous studies demonstrated that Mycobacterium bovis bacillus Calmette-Guérin (BCG) can directly interact with human NK cells and induce the proliferation, gamma interferon production, and cytotoxic activity of such cells without the need for accessory cells. Thus, the aim of the present study was to identify th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00870-07
更新日期:2008-04-01 00:00:00
abstract::We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.5.3006-3011.2006
更新日期:2006-05-01 00:00:00
abstract::We report the cloning of the gene encoding the 32-kDa lipoprotein, designated LipL32, the most prominent protein in the leptospiral protein profile. We obtained the N-terminal amino acid sequence of a staphylococcal V8 proteolytic-digest fragment to design an oligonucleotide probe. A Lambda-Zap II library containing E...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.4.2276-2285.2000
更新日期:2000-04-01 00:00:00
abstract::This study assessed the effect of periodontal therapy on specific serum antibody concentration, expressed as titer, and antibody binding strength, expressed as relative avidity. The immune responses to Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans were investigated. Antibody titer was assayed by en...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.9.3411-3416.1995
更新日期:1995-09-01 00:00:00
abstract::Legionella pneumophila, the gram-negative agent of Legionnaires' disease, possesses type IV pili and a type II protein secretion (Lsp) system, both of which are dependent upon the PilD prepilin peptidase. By analyzing multiple pilD mutants and various types of Lsp mutants as well as performing trans-complementation of...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.1.310-321.2004
更新日期:2004-01-01 00:00:00
abstract::A total of five bacteriological samples from the periodontal pockets of two sisters with localized juvenile periodontitis and their mother with advanced periodontitis was studied. Gram-negative anaerobic rods were predominant in the samples. Bacteroides intermedius and Bacteroides loescheii were the most predominant s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.45.1.118-121.1984
更新日期:1984-07-01 00:00:00
abstract::The suppression of T-cell deoxyribonucleic acid (DNA) synthesis by serum from mice acutely with murine cytomegalovirus (MCMV) was investigated. Spleen cells from uninfected mice were exposed to concanavalin A in the presence of serum taken from mice at various times after infection with MCMV. The capacity of the serum...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.17.2.378-381.1977
更新日期:1977-08-01 00:00:00
abstract::The bacterium Neisseria meningitidis is the causative agent of meningitis and sepsis. A generally effective vaccine against N. meningitidis serogroup B is not yet available, but outer membrane vesicle vaccines are in development. These vaccines contain lipopolysaccharide (LPS). The inclusion of N. meningitidis wild-ty...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00846-07
更新日期:2007-12-01 00:00:00
abstract::Cell surface protein SSP-5 in the oral bacterium Streptococcus gordonii M5 binds human salivary agglutinin in a Ca(2+)-dependent reaction (D.R. Demuth, E.E. Golub, and D. Malamud, J. Biol. Chem. 265:7120-7126, 1990). The region of the gene encoding an N-terminal segment of a related polypeptide (SspA) in S. gordonii D...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.8.3199-3208.1993
更新日期:1993-08-01 00:00:00
abstract::A genomic library of meningococcal DNA from a clinical isolate of Neisseria meningitidis was constructed in the expression vector lambda gt11. Outer membrane complex was prepared from the same strain and used to immunize rabbits to raise polyclonal anti-outer membrane complex serum. The amplified library was probed wi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.11.2734-2740.1987
更新日期:1987-11-01 00:00:00
abstract::The protective efficacy of Mycobacterium bovis BCG can be markedly augmented by stable integration of Mycobacterium tuberculosis genomic region RD1. BCG complemented with RD1 (BCG::RD1) encodes nine additional proteins. Among them, 10-kDa culture filtrate protein (CFP-10) and ESAT-6 (6-kDa early secreted antigenic tar...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.4.2170-2176.2004
更新日期:2004-04-01 00:00:00
abstract::Mouse spleen cells which normally cannot support the in vivo replication of vesicular stomatitis virus (VSV) became susceptible to VSV infection after the intraperitoneal growth of certain syngeneic and allogeneic tumors. After 3 days' growth of P815 tumor cells in syngeneic DBA/2 mice, the viral-permissive state for ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.32.3.1014-1023.1981
更新日期:1981-06-01 00:00:00
abstract::Antimicrobial peptides play an important role in host defense against Vibrio cholerae Generally, the V. cholerae O1 classical biotype is polymyxin B (PB) sensitive and El Tor is relatively resistant. Detection of classical biotype traits like the production of classical cholera toxin and PB sensitivity in El Tor strai...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00080-20
更新日期:2020-04-20 00:00:00
abstract::Experimental infection of mice with a virulent strain of Mycobacterium avium leads to a slowly progressive disease, which we have previously shown culminates in loss of gamma interferon (IFN-gamma) production by T lymphocytes and death of the animals approximately 40 weeks after infection. Here we investigated the cha...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.1.27-35.2002
更新日期:2002-01-01 00:00:00
abstract::Diffusely adhering Escherichia coli (DAEC) strains expressing F1845 fimbrial adhesin or Dr hemagglutinin belonging to the Afa/Dr family of adhesins infect cultured polarized human intestinal cells through recognition of the brush border-associated decay-accelerating factor (DAF; CD55) as a receptor. The wild-type Afa/...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.10.5979-5990.2000
更新日期:2000-10-01 00:00:00
abstract::Catheter-associated urinary tract infections (CAUTIs) constitute the majority of nosocomial UTIs and pose significant clinical challenges. Enterococcal species are among the predominant causative agents of CAUTIs. However, very little is known about the pathophysiology of Enterococcus-mediated UTIs. We optimized a mur...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00711-10
更新日期:2010-10-01 00:00:00
abstract::Patients that have suffered a major injury may sustain a period of immunocompromise and altered Th1/Th2 cytokine balance that can predispose them to opportunistic infections. Pseudomonas aeruginosa is frequently a causative organism for nosocomial infections in critically ill patients and is associated with high morta...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.12.6892-6901.2004
更新日期:2004-12-01 00:00:00
abstract::The dermotropism of Cryptococcus neoformans SLHA in congenitally athymic (nu/nu) and doubly immunodeficient beige-athymic (bg/bg-nu/nu) mice is described. Both bg/bg-nu/nu and nu/nu mice developed cutaneous cryptococcosis within 7 to 12 days following intravenous challenge with 10(4) encapsulated yeast cells. Macrosco...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.5.1785-1789.1991
更新日期:1991-05-01 00:00:00
abstract::Exposure to bacterial superantigens such as staphylococcal enterotoxin B (SEB) leads to the induction of toxic shock syndrome which results in multiorgan failure, including liver damage. In the present study, we investigated the role of CD44 in SEB-induced liver injury. Injection of SEB into d-galactosamine-sensitized...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.1.50-61.2005
更新日期:2005-01-01 00:00:00
abstract::FMS-like tyrosine kinase-3 ligand (Flt3L) is a dendritic cell (DC) growth and differentiation factor with potential in antitumor therapies and antibacterial immunization strategies. However, the effect of systemic Flt3L treatment on lung-protective immunity against bacterial infection is incompletely defined. Here, we...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00854-12
更新日期:2012-12-01 00:00:00
abstract::Analysis of the partition in a two-polymer phase system of Salmonella typhimurium R mutants with different susceptibility to phagocytosis distinguished between the mutants. Close to 80% of the R mutants least resistant to phagocytosis accumulated in the dextran-rich phase, whereas more phagocytosis-resistant mutants s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.1.36-41.1973
更新日期:1973-07-01 00:00:00
abstract::The ability of intracellular pathogens to sense and adapt to the hostile environment of the host is an important factor governing virulence. We have sequenced the operon encoding the major heat shock proteins GroES and GroEL in the gram-positive food-borne pathogen Listeria monocytogenes. The operon has a conserved or...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.6.3924-3932.2001
更新日期:2001-06-01 00:00:00
abstract::Bacillus anthracis is surrounded by a polypeptide capsule composed of poly-gamma-d-glutamic acid (gammaDPGA). In a previous study, we reported that a monoclonal antibody (MAb F26G3) reactive with the capsular polypeptide is protective in a murine model of pulmonary anthrax. The present study examined a library of six ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01133-06
更新日期:2007-01-01 00:00:00
abstract::Changes in the structural components of the Streptococcus pyogenes membrane between exponential and early stationary phases of growth are reported. The overall protein composition ranged from 70 to 73% of the dry weight of the membranes, irrespective of the phase of growth from which they were isolated. Amino acid ana...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.26.3.883-891.1979
更新日期:1979-12-01 00:00:00
abstract::Chronic lung infections with Pseudomonas aeruginosa biofilms are associated with refractory and fatal pneumonia in cystic fibrosis (CF). In this study, a group of genomically diverse P. aeruginosa isolates were compared with the reference strain PAO1 to assess the roles of motility, twitching, growth rate, and overpro...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.1.133-144.2004
更新日期:2004-01-01 00:00:00
abstract::A nonhuman primate model for malaria vaccine development allowing reliable, stringent sporozoite challenge and evaluation of both cellular and antibody responses is needed. We therefore constructed a multicomponent, multistage DNA vaccine for the simian malaria species Plasmodium knowlesi including two preerythrocytic...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.69.9.5565-5572.2001
更新日期:2001-09-01 00:00:00
abstract::Newly hatched chicks were vaccinated orally with a genetically defined Salmonella enteritidis aroA candidate, strain CVL30. In chickens immunized with 10(5) or 10(9) CFU and challenged by the intravenous route with 10(8) CFU of S. enteritidis 109 Nalr at 8 weeks old, there were similar reductions in colonization of th...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.11.4747-4754.1994
更新日期:1994-11-01 00:00:00
abstract::The antiphagocytic effect of the Staphylococcus aureus capsule is known to be related to its ability to interfere with opsonization by normal human serum. In this study, evidence is presented with isolated cell surface components which indicates that the capsule hinders opsonization by masking cell wall peptidoglycan....
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.23.2.502-508.1979
更新日期:1979-02-01 00:00:00
abstract::Secretory immunoglobulin A (SIgA) antibodies directed against the O antigen of lipopolysaccharide (LPS) are the primary determinants of mucosal immunity to gram-negative enteric pathogens. However, the underlying mechanisms by which these antibodies interfere with bacterial colonization and invasion of intestinal epit...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00416-08
更新日期:2008-09-01 00:00:00