Effect of iontophoretic and topical application of antiviral agents in treatment of experimental HSV-1 keratitis in rabbits.

abstract：PURPOSE:We investigated the mechanism of tamoxifen (TAM) retinotoxicity using human retinal pigment epithelial (RPE)-derived (ARPE-19) and photoreceptor-derived (661W) cells. METHODS:Cultured ARPE-19 and 661W cells were treated with 5 to 10 μM TAM, and the resultant cell death was quantified using lactate dehydrogenas...

journal_title：Investigative ophthalmology & visual science

authors： Cho KS,Yoon YH,Choi JA,Lee SJ,Koh JY

更新日期：2012-08-09 00:00:00

abstract：PURPOSE:The lipid layer of the tear film forms a barrier to evaporation. Evaporation is a major cause of tear thinning between blinks and tear breakup. The purpose of this study was to investigate the relation between tear film thinning and lipid layer thickness before and after instillation of an emulsion eye drop. M...

journal_title：Investigative ophthalmology & visual science

authors： King-Smith PE,Hinel EA,Nichols JJ

更新日期：2010-05-01 00:00:00

abstract：Purpose:Applying CNGA3 gene augmentation therapy to cure a novel causative mutation underlying achromatopsia (ACHM) in sheep. Methods:Impaired vision that spontaneously appeared in newborn lambs was characterized by behavioral, electroretinographic (ERG), and histologic techniques. Deep-sequencing reads of an affected...

journal_title：Investigative ophthalmology & visual science

authors： Gootwine E,Abu-Siam M,Obolensky A,Rosov A,Honig H,Nitzan T,Shirak A,Ezra-Elia R,Yamin E,Banin E,Averbukh E,Hauswirth WW,Ofri R,Seroussi E

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Fibroblast growth factor-10 (FGF10) can modulate extracellular matrix associated genes and, therefore, it could be a myopia susceptibility gene. This study used an animal model, single nucleotide polymorphisms (SNPs) association, and genetic functional assay to evaluate FGF10 gene for myopia. METHODS:The expre...

journal_title：Investigative ophthalmology & visual science

authors： Hsi E,Chen KC,Chang WS,Yu ML,Liang CL,Juo SH

更新日期：2013-05-07 00:00:00

abstract：PURPOSE:Neural ectopic rewiring in retinal degeneration such as retinitis pigmentosa (RP) may form functional synapses between cones and rod bipolar cells that cause atypical signal processing. In this study, the multifocal electroretinograms (mfERGs) of a large animal model of RP, the rhodopsin P347L transgenic (Tg) p...

journal_title：Investigative ophthalmology & visual science

authors： Ng YF,Chan HH,Chu PH,To CH,Gilger BC,Petters RM,Wong F

更新日期：2008-05-01 00:00:00

abstract：Purpose:This study evaluates the associations of haplotype-tagging single nucleotide polymorphisms (SNPs) in the PARL-ABCC5-HTR3D-HTR3C region with primary angle closure glaucoma (PACG), with a view to identify the responsible SNP in this region. Methods:Thirty SNPs from the PARL-ABCC5-HTR3D-HTR3C region were genotype...

journal_title：Investigative ophthalmology & visual science

authors： Tang FY,Ma L,Tam POS,Pang CP,Tham CC,Chen LJ

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:To identify risk factors for the development of high-risk proliferative diabetic retinopathy (PDR) and for the development of severe visual loss or vitrectomy (SVLV) in eyes assigned to deferral of photocoagulation in the Early Treatment Diabetic Retinopathy Study (ETDRS). METHODS:Multivariable Cox models were...

journal_title：Investigative ophthalmology & visual science

authors： Davis MD,Fisher MR,Gangnon RE,Barton F,Aiello LM,Chew EY,Ferris FL 3rd,Knatterud GL

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:Endogenous anterior uveitis (AU), when untreated, may lead to vision loss. This study compared the safety and efficacy of difluprednate versus prednisolone acetate for the treatment of this condition. METHODS:This phase III, double-masked, noninferiority study randomized patients with mild to moderate endogeno...

journal_title：Investigative ophthalmology & visual science

authors： Sheppard JD,Toyos MM,Kempen JH,Kaur P,Foster CS

更新日期：2014-05-06 00:00:00

abstract：PURPOSE:Adipose-derived stem cells (ASCs) have gained importance due to their myriad potential clinical applications. We hypothesize that progenitor cells also exist besides those conventionally isolated from the stromal vascular fraction (SVF). METHOD:Central and medial orbital adipose tissues obtained from patients ...

journal_title：Investigative ophthalmology & visual science

authors： Chen SY,Mahabole M,Horesh E,Wester S,Goldberg JL,Tseng SC

更新日期：2014-07-03 00:00:00

abstract：PURPOSE:To evaluate the role of manganese superoxide dismutase (Mn-SOD) and copper/zinc superoxide dismutase (Cu/Zn-SOD) in cellular protection of the optic nerve against the oxidative injury that contributes to demyelination in experimental allergic encephalomyelitis (EAE). METHODS:Immunocytochemistry for Mn-SOD and ...

journal_title：Investigative ophthalmology & visual science

authors： Qi X,Guy J,Nick H,Valentine J,Rao N

更新日期：1997-05-01 00:00:00

abstract：:The peroxidase-antiperoxidase method was used to study ten surgically obtained human optic nerve gliomas (pilocytic astrocytomas). All tissues were formalin fixed and paraffin embedded. Primary antisera included glial fibrillary acidic protein (GFAP), HNK-1 (type 1 astrocyte precursor marker), A2B5 (type 2 astrocyte p...

journal_title：Investigative ophthalmology & visual science

authors： Cutarelli PE,Roessmann UR,Miller RH,Specht CS,Grossniklaus HE

更新日期：1991-08-01 00:00:00

abstract：PURPOSE:A relationship has been reported between the presence of peripheral neuropathy and the density and shape of corneal nerve fibers. Peripheral neuropathy is a debilitating condition that arises from many common health problems, and its presence is often confirmed with an invasive clinical test called intramuscula...

journal_title：Investigative ophthalmology & visual science

authors： Holmes TJ,Pellegrini M,Miller C,Epplin-Zapf T,Larkin S,Luccarelli S,Staurenghi G

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To determine whether human retinal pigment epithelial (hRPE) cells produce activin, a growth factor in the transforming growth factor beta family, and to characterize growth regulatory effects of activin on retinal pigment epithelium. METHODS:mRNA expression was examined using polymerase chain reaction with pr...

journal_title：Investigative ophthalmology & visual science

authors： Jaffe GJ,Harrison CE,Lui GM,Roberts WL,Goldsmith PC,Mesiano S,Jaffe RB

更新日期：1994-06-01 00:00:00

abstract：PURPOSE:To determine whether constitutive signal flow arising from defective rhodopsin shut-off causes photoreceptor cell death in arrestin knockout mice. METHODS:The retinas of cyclic-light-reared, pigmented arrestin knockout mice and wild-type littermate control mice were examined histologically for photoreceptor ce...

journal_title：Investigative ophthalmology & visual science

authors： Chen J,Simon MI,Matthes MT,Yasumura D,LaVail MM

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:To evaluate the performance and potential clinical role of three-dimensional (3D) 1060-nm OCT by generating choroidal thickness (ChT) maps in patients of different ages with different degrees of ametropia and axial lengths and to investigate the effect of cataract grade on OCT retinal imaging quality. METHODS:...

journal_title：Investigative ophthalmology & visual science

authors： Esmaeelpour M,Povazay B,Hermann B,Hofer B,Kajic V,Kapoor K,Sheen NJ,North RV,Drexler W

更新日期：2010-10-01 00:00:00

abstract：Purpose:To examine the early glial reactivity and neuron damage in response to short-term cerebrospinal fluid pressure (CSFp) reduction, as compared with intraocular pressure (IOP) elevation. Methods:The experiment included 54 male Sprague-Dawley rats with elevated translaminar cribrosa pressure difference (TLPD), def...

journal_title：Investigative ophthalmology & visual science

authors： Li XX,Zhang Z,Zeng HY,Wu S,Liu L,Zhang JX,Liu Q,Yang DY,Wang NL

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:To investigate the specific role of very late antigen-1 (VLA-1; also known as integrin α1β1) in corneal inflammatory lymphangiogenesis in vivo and lymphatic endothelial cell functions in vitro. METHODS:A standard suture-induced corneal inflammatory lymphangiogenesis model was used in normal adult BALB/c mice t...

journal_title：Investigative ophthalmology & visual science

authors： Grimaldo S,Yuen D,Ecoiffier T,Chen L

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To unravel the molecular genetic background in families with congenital cataract in association with microcornea (CCMC, OMIM 116150). METHODS:CCMC families were recruited from a national database on hereditary eye diseases; DNA was procured from a national gene bank on hereditary eye diseases and by blood samp...

journal_title：Investigative ophthalmology & visual science

authors： Hansen L,Yao W,Eiberg H,Kjaer KW,Baggesen K,Hejtmancik JF,Rosenberg T

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:To identify the prognostic value of extraocular extension in enucleated uveal melanoma (UM) patients and to correlate extraocular extension to chromosomal aberrations, metastasis-free survival (MFS), and clinico-histopathological risk factors. METHODS:Retrospective study of patients with UM treated with enucle...

journal_title：Investigative ophthalmology & visual science

authors： van Beek JG,Koopmans AE,Vaarwater J,de Rooi JJ,Paridaens D,Naus NC,de Klein A,Verdijk RM,Kiliç E

更新日期：2014-03-04 00:00:00

abstract：PURPOSE:To assess the impact of glaucoma-related vision loss on measures of out-loud reading, including time to say individual words, interval time between consecutive words, lexical errors, skipped words, and repetitions. METHODS:Glaucoma subjects (n = 63) with bilateral visual field loss and glaucoma suspect control...

journal_title：Investigative ophthalmology & visual science

authors： Mathews PM,Rubin GS,McCloskey M,Salek S,Ramulu PY

更新日期：2015-03-03 00:00:00

abstract：Purpose:To develop and use a custom virtual fields method (VFM) to assess the biomechanical properties of human prelamina and lamina cribrosa (LC) in vivo. Methods:Clinical data of 20 healthy, 20 ocular hypertensive (OHT), 20 primary open-angle glaucoma, and 16 primary angle-closure glaucoma eyes were analyzed. For ea...

journal_title：Investigative ophthalmology & visual science

authors： Zhang L,Beotra MR,Baskaran M,Tun TA,Wang X,Perera SA,Strouthidis NG,Aung T,Boote C,Girard MJA

更新日期：2020-03-09 00:00:00

abstract：:Docosapentaenoic acid (22:5 omega 6), a minor constituent (less than 4%) of photoreceptor outer segment membranes in all vertebrate species examined to date, comprises 23% of the fatty acids in total lipids from rabbit outer segment membranes. This fatty acid is a significant constituent of each of the three major pho...

journal_title：Investigative ophthalmology & visual science

authors： Nielsen JC,Maude MB,Hughes H,Anderson RE

更新日期：1986-02-01 00:00:00

abstract：PURPOSE:Air puff systems have been presented recently to measure corneal biomechanical properties in vivo. In our study we tested the influence of several factors on corneal deformation to an air puff: IOP, corneal rigidity, dehydration, presence of sclera, and in vivo versus in vitro conditions. METHODS:We used 14 fr...

journal_title：Investigative ophthalmology & visual science

authors： Kling S,Marcos S

更新日期：2013-07-26 00:00:00

abstract：PURPOSE:Dry eye disease (DED) is associated with ocular surface inflammation that is thought to be mediated primarily by CD4 T cells. The purpose of this study was to investigate whether this T cell-mediated immune response is generated in the lymphoid compartment and to characterize the functional phenotype of the T c...

journal_title：Investigative ophthalmology & visual science

authors： El Annan J,Chauhan SK,Ecoiffier T,Zhang Q,Saban DR,Dana R

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To quantify the prevalence and effect on visual acuity of macular cysts in a large cohort of patients with retinitis pigmentosa. METHODS:In 316 patients with typical forms of retinitis pigmentosa, visual acuity was measured with Early Treatment Diabetic Retinopathy Study (ETDRS) charts, macular cysts were dete...

journal_title：Investigative ophthalmology & visual science

authors： Sandberg MA,Brockhurst RJ,Gaudio AR,Berson EL

更新日期：2008-10-01 00:00:00

abstract：Purpose:To investigate the relationship between lens power and age as well as the relationship between lens power and axial length (AL) in Chinese children and adolescents. Methods:The participants underwent a comprehensive ophthalmic examination that included AL, cycloplegic refraction, and Pentacam measurements. The...

journal_title：Investigative ophthalmology & visual science

authors： Xiong S,Zhang B,Hong Y,He X,Zhu J,Zou H,Xu X

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:To compare adult discrimination performance on nine pediatric visual acuity tests to determine the consistency of optotype design. METHODS:After their binocular acuity was measured with each test, eight adult observers (mean age, 27 years ± 6.3 SD; three emmetropes and five corrected myopes) were shown isolate...

journal_title：Investigative ophthalmology & visual science

authors： Candy TR,Mishoulam SR,Nosofsky RM,Dobson V

更新日期：2011-06-16 00:00:00

abstract：PURPOSE:Weak eye muscles can cause ophthalmic disorders, and in particular, strabismus. Exogenous trophic factors such as cardiotrophin (CT)-1 and insulin-like growth factor (IGF) have been shown to increase the contractile force of adult heart and skeletal muscles, respectively. In the current study, the effects of en...

journal_title：Investigative ophthalmology & visual science

authors： Chen J,von Bartheld CS

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:The current study aims to evaluate a porous silicon-based drug delivery system meant for sustained delivery of dexamethasone (Dex) to the vitreous and retina. METHODS:Dexamethasone was grafted covalently into the pore walls of fully oxidized porous silicon particles (pSiO2-COO-Dex), which then was evaluated fo...

journal_title：Investigative ophthalmology & visual science

authors： Hou H,Wang C,Nan K,Freeman WR,Sailor MJ,Cheng L

更新日期：2016-02-01 00:00:00

abstract：Purpose:Ocular neovascularization (NV) is a pathologic process characterized by the proliferation and infiltration of various types of cells such as RPE, glial, and endothelial cells, which interact with proangiogenic factors and inflammatory cytokines. Endocan is known to be enriched in retinal endothelial tip cells u...

journal_title：Investigative ophthalmology & visual science

authors： Su T,Zhong Y,Demetriades AM,Shen J,Sui A,Yao Y,Gao Y,Zhu Y,Shen X,Xie B

更新日期：2018-02-01 00:00:00